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Heme oxygenase 1: a novel oncogene in multiple gynecological cancers
Heme oxygenase 1 (HO-1), also known as heat shock protein 32 (HSP32), is a stress-inducible enzyme. In the past, it was believed to participate in maintaining cell homeostasis, reducing oxidative stress damage and exerting anti-apoptotic effects. When exposed to noxious stimulation, the expression o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241721/ https://www.ncbi.nlm.nih.gov/pubmed/34239353 http://dx.doi.org/10.7150/ijbs.61073 |
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author | Lu, Jia-Jing Abudukeyoumu, Ayitila Zhang, Xing Liu, Li-Bing Li, Ming-Qing Xie, Feng |
author_facet | Lu, Jia-Jing Abudukeyoumu, Ayitila Zhang, Xing Liu, Li-Bing Li, Ming-Qing Xie, Feng |
author_sort | Lu, Jia-Jing |
collection | PubMed |
description | Heme oxygenase 1 (HO-1), also known as heat shock protein 32 (HSP32), is a stress-inducible enzyme. In the past, it was believed to participate in maintaining cell homeostasis, reducing oxidative stress damage and exerting anti-apoptotic effects. When exposed to noxious stimulation, the expression of HO-1 in the body will increase, antagonizing these oxidative stresses and protecting our bodies. Recently, many studies showed that HO-1 was also highly-expressed in multiple gynecological cancers (such as ovarian cancer, cervical cancer and endometrial cancer), suggesting that it should be closely related to cell proliferation, metastasis, immune regulation and angiogenesis as an oncogene. This review summarizes the different effects of HO-1 under normal and diseased conditions with a brief discussion of its implications on the diagnosis and treatment of gynecological cancers, aiming to provide a new clue for prevention and treatment of diseases. |
format | Online Article Text |
id | pubmed-8241721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-82417212021-07-07 Heme oxygenase 1: a novel oncogene in multiple gynecological cancers Lu, Jia-Jing Abudukeyoumu, Ayitila Zhang, Xing Liu, Li-Bing Li, Ming-Qing Xie, Feng Int J Biol Sci Review Heme oxygenase 1 (HO-1), also known as heat shock protein 32 (HSP32), is a stress-inducible enzyme. In the past, it was believed to participate in maintaining cell homeostasis, reducing oxidative stress damage and exerting anti-apoptotic effects. When exposed to noxious stimulation, the expression of HO-1 in the body will increase, antagonizing these oxidative stresses and protecting our bodies. Recently, many studies showed that HO-1 was also highly-expressed in multiple gynecological cancers (such as ovarian cancer, cervical cancer and endometrial cancer), suggesting that it should be closely related to cell proliferation, metastasis, immune regulation and angiogenesis as an oncogene. This review summarizes the different effects of HO-1 under normal and diseased conditions with a brief discussion of its implications on the diagnosis and treatment of gynecological cancers, aiming to provide a new clue for prevention and treatment of diseases. Ivyspring International Publisher 2021-06-01 /pmc/articles/PMC8241721/ /pubmed/34239353 http://dx.doi.org/10.7150/ijbs.61073 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Review Lu, Jia-Jing Abudukeyoumu, Ayitila Zhang, Xing Liu, Li-Bing Li, Ming-Qing Xie, Feng Heme oxygenase 1: a novel oncogene in multiple gynecological cancers |
title | Heme oxygenase 1: a novel oncogene in multiple gynecological cancers |
title_full | Heme oxygenase 1: a novel oncogene in multiple gynecological cancers |
title_fullStr | Heme oxygenase 1: a novel oncogene in multiple gynecological cancers |
title_full_unstemmed | Heme oxygenase 1: a novel oncogene in multiple gynecological cancers |
title_short | Heme oxygenase 1: a novel oncogene in multiple gynecological cancers |
title_sort | heme oxygenase 1: a novel oncogene in multiple gynecological cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241721/ https://www.ncbi.nlm.nih.gov/pubmed/34239353 http://dx.doi.org/10.7150/ijbs.61073 |
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