Cargando…

Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease

Extracellular neuritic plaques composed of amyloid‑β (Aβ) protein and intracellular neurofibrillary tangles containing phosphorylated tau protein are the two hallmark proteins of Alzheimer's disease (AD), and the separate neurotoxicity of these proteins in AD has been extensively studied. Howev...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Huiqin, Wei, Wei, Zhao, Ming, Ma, Lina, Jiang, Xuefan, Pei, Hui, Cao, Yu, Li, Hao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241728/ https://www.ncbi.nlm.nih.gov/pubmed/34239348 http://dx.doi.org/10.7150/ijbs.57078

Ejemplares similares

Possible Mechanisms of Tau Spread and Toxicity in Alzheimer’s Disease
por: Zhang, Huiqin, et al.
Publicado: (2021)

Role of Aβ in Alzheimer’s-related synaptic dysfunction
por: Zhang, Huiqin, et al.
Publicado: (2022)

The Role of Amyloid-Beta and Tau in the Early Pathogenesis of Alzheimer’s Disease
por: Yin, Xiaomin, et al.
Publicado: (2021)

Targeting the γ-/β-secretase interaction reduces β-amyloid generation and ameliorates Alzheimer’s disease-related pathogenesis
por: Cui, Jin, et al.
Publicado: (2015)

Advances in the Pathogenesis of Alzheimer’s Disease: Focusing on Tau-Mediated Neurodegeneration
por: Duan, Yale, et al.
Publicado: (2012)

The roles of lipid and glucose metabolism in modulation of β-amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease
por: Sato, Naoyuki, et al.
Publicado: (2015)

Association of Methylenetetrahydrofolate Reductase C677T Gene Polymorphisms with Mild Cognitive Impairment Susceptibility: A Systematic Review and Meta-Analysis
por: Sun, Jiahui, et al.
Publicado: (2021)

The Correlations Between Plasma Fibrinogen With Amyloid-Beta and Tau Levels in Patients With Alzheimer’s Disease
por: Fan, Dong-Yu, et al.
Publicado: (2021)

Oligomerization and Conformational Change Turn Monomeric β-Amyloid and Tau Proteins Toxic: Their Role in Alzheimer’s Pathogenesis
por: Penke, Botond, et al.
Publicado: (2020)

Tau Clearance Mechanisms and Their Possible Role in the Pathogenesis of Alzheimer Disease
por: Chesser, Adrianne S., et al.
Publicado: (2013)

Associations of plasma angiostatin and amyloid-β and tau levels in Alzheimer’s disease
por: Cheng, Yuan, et al.
Publicado: (2022)

Interleukin-3 is associated with sTREM2 and mediates the correlation between amyloid-β and tau pathology in Alzheimer’s disease
por: Wang, Zhi-Bo, et al.
Publicado: (2022)

Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species
por: Chen, Xu-Qiao, et al.
Publicado: (2019)

Lysine 63-linked ubiquitination of tau oligomers contributes to the pathogenesis of Alzheimer’s disease
por: Puangmalai, Nicha, et al.
Publicado: (2022)

β-Amyloid: the key peptide in the pathogenesis of Alzheimer’s disease
por: Sun, Xiaojuan, et al.
Publicado: (2015)

Association between Alzheimer’s disease pathogenesis and early demyelination and oligodendrocyte dysfunction
por: Dong, Yu-Xia, et al.
Publicado: (2018)

A novel tau‐based rhesus monkey model of Alzheimer's pathogenesis
por: Beckman, Danielle, et al.
Publicado: (2021)

Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40
por: Hu, Xiaoyan, et al.
Publicado: (2014)

Associations between blood-based biomarkers of Alzheimer’s disease with cognition in motoric cognitive risk syndrome: A pilot study using plasma Aβ42 and total tau
por: Chen, Pei-Hao, et al.
Publicado: (2022)

Recent Computational Advances Regarding Amyloid-β and Tau Membrane Interactions in Alzheimer’s Disease
por: Nguyen, Phuong H., et al.
Publicado: (2023)

Thermodynamics of the Interaction between Alzheimer's Disease Related Tau Protein and DNA
por: Camero, Sergio, et al.
Publicado: (2014)

Corrigendum: Associations between blood-based biomarkers of Alzheimer's disease with cognition in motoric cognitive risk syndrome: A pilot study using plasma Aβ42 and total tau
por: Chen, Pei-Hao, et al.
Publicado: (2023)

Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease
por: Ossenkoppele, Rik, et al.
Publicado: (2019)

Elevating the Levels of Calcium Ions Exacerbate Alzheimer’s Disease via Inducing the Production and Aggregation of β-Amyloid Protein and Phosphorylated Tau
por: Guan, Pei-Pei, et al.
Publicado: (2021)

The viral hypothesis in Alzheimer’s disease: SARS-CoV-2 on the cusp
por: Liu, Nanyang, et al.
Publicado: (2023)

The Dichotomy of Alzheimer’s Disease Pathology: Amyloid-β and Tau
por: Ashford, J. Wesson
Publicado: (2019)

Interacting Models of Amyloid-β and Tau Proteins: An Approach to Identify Drug Targets in Alzheimer’s Disease
por: Priya, Khadgawat, et al.
Publicado: (2021)

Traditional Chinese Medicine Huannao Yicong Decoction Extract Decreases Tau Hyperphosphorylation in the Brain of Alzheimer's Disease Model Rats Induced by Aβ (1–42)
por: Cao, Yu, et al.
Publicado: (2016)

Aβ and Tau Regulate Microglia Metabolism via Exosomes in Alzheimer’s Disease
por: Zhao, Yuanxin, et al.
Publicado: (2022)

Connections between ApoE, sleep, and Aβ and tau pathologies in Alzheimer’s disease
por: Sadleir, Katherine R., et al.
Publicado: (2023)

Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer’s disease
por: Cai, Yue, et al.
Publicado: (2023)

BMP4 overexpression induces the upregulation of APP/Tau and memory deficits in Alzheimer’s disease
por: Zhang, Xiaoqing, et al.
Publicado: (2021)

Up-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer’s disease
por: Chen, Caoyi, et al.
Publicado: (2017)

Staging tau pathology with tau PET in Alzheimer’s disease: a longitudinal study
por: Chen, Shi-Dong, et al.
Publicado: (2021)

Interactions between Aβ and Mutated Tau Lead to Polymorphism and Induce Aggregation of Aβ-Mutated Tau Oligomeric Complexes
por: Raz, Yoav, et al.
Publicado: (2013)

Yuan-zhi-san inhibits tau protein aggregation in an Aβ(1–40)-induced Alzheimer's disease rat model via the ubiquitin-proteasome system
por: Li, Bin, et al.
Publicado: (2021)

Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer’s disease –conformist, nonconformist, and realistic prospects for AD pathogenesis
por: Li, Hongmei, et al.
Publicado: (2018)

Passive immunotherapies targeting Aβ and tau in Alzheimer's disease
por: Plotkin, Steven S., et al.
Publicado: (2020)

GSK3β and Tau Protein in Alzheimer’s Disease and Epilepsy
por: Toral-Rios, Danira, et al.
Publicado: (2020)

β-amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of Alzheimer's disease
por: Zhao, Xia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_gl7bhtb2sc8dqjhvquv94qr6s1