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Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy

Intervertebral disc (IVD) degeneration (IDD) is a multifactorial pathological process associated with low back pain (LBP). The pathogenesis is complicated, and the main pathological changes are IVD cell apoptosis and extracellular matrix (ECM) degradation. Apoptotic cell loss leads to ECM degradatio...

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Autores principales: Zhang, Xiao-bo, Hu, Yi-cun, Cheng, Peng, Zhou, Hai-yu, Chen, Xiang-yi, Wu, Ding, Zhang, Rui-hao, Yu, De-chen, Gao, Xi-dan, Shi, Jin-tao, Zhang, Kai, Li, Shao-long, Song, Peng-jie, Wang, Ke-ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241771/
https://www.ncbi.nlm.nih.gov/pubmed/34220308
http://dx.doi.org/10.7150/ijms.59171
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author Zhang, Xiao-bo
Hu, Yi-cun
Cheng, Peng
Zhou, Hai-yu
Chen, Xiang-yi
Wu, Ding
Zhang, Rui-hao
Yu, De-chen
Gao, Xi-dan
Shi, Jin-tao
Zhang, Kai
Li, Shao-long
Song, Peng-jie
Wang, Ke-ping
author_facet Zhang, Xiao-bo
Hu, Yi-cun
Cheng, Peng
Zhou, Hai-yu
Chen, Xiang-yi
Wu, Ding
Zhang, Rui-hao
Yu, De-chen
Gao, Xi-dan
Shi, Jin-tao
Zhang, Kai
Li, Shao-long
Song, Peng-jie
Wang, Ke-ping
author_sort Zhang, Xiao-bo
collection PubMed
description Intervertebral disc (IVD) degeneration (IDD) is a multifactorial pathological process associated with low back pain (LBP). The pathogenesis is complicated, and the main pathological changes are IVD cell apoptosis and extracellular matrix (ECM) degradation. Apoptotic cell loss leads to ECM degradation, which plays an essential role in IDD pathogenesis. Apoptosis regulation may be a potential attractive therapeutic strategy for IDD. Previous studies have shown that IVD cell apoptosis is mainly induced by the death receptor pathway, mitochondrial pathway, and endoplasmic reticulum stress (ERS) pathway. This article mainly summarizes the factors that induce IDD and apoptosis, the relationship between the three apoptotic pathways and IDD, and potential therapeutic strategies. Preliminary animal and cell experiments show that targeting apoptotic pathway genes or drug inhibition can effectively inhibit IVD cell apoptosis and slow IDD progression. Targeted apoptotic pathway inhibition may be an effective strategy to alleviate IDD at the gene level. This manuscript provides new insights and ideas for IDD therapy.
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spelling pubmed-82417712021-07-01 Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy Zhang, Xiao-bo Hu, Yi-cun Cheng, Peng Zhou, Hai-yu Chen, Xiang-yi Wu, Ding Zhang, Rui-hao Yu, De-chen Gao, Xi-dan Shi, Jin-tao Zhang, Kai Li, Shao-long Song, Peng-jie Wang, Ke-ping Int J Med Sci Review Intervertebral disc (IVD) degeneration (IDD) is a multifactorial pathological process associated with low back pain (LBP). The pathogenesis is complicated, and the main pathological changes are IVD cell apoptosis and extracellular matrix (ECM) degradation. Apoptotic cell loss leads to ECM degradation, which plays an essential role in IDD pathogenesis. Apoptosis regulation may be a potential attractive therapeutic strategy for IDD. Previous studies have shown that IVD cell apoptosis is mainly induced by the death receptor pathway, mitochondrial pathway, and endoplasmic reticulum stress (ERS) pathway. This article mainly summarizes the factors that induce IDD and apoptosis, the relationship between the three apoptotic pathways and IDD, and potential therapeutic strategies. Preliminary animal and cell experiments show that targeting apoptotic pathway genes or drug inhibition can effectively inhibit IVD cell apoptosis and slow IDD progression. Targeted apoptotic pathway inhibition may be an effective strategy to alleviate IDD at the gene level. This manuscript provides new insights and ideas for IDD therapy. Ivyspring International Publisher 2021-05-27 /pmc/articles/PMC8241771/ /pubmed/34220308 http://dx.doi.org/10.7150/ijms.59171 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Zhang, Xiao-bo
Hu, Yi-cun
Cheng, Peng
Zhou, Hai-yu
Chen, Xiang-yi
Wu, Ding
Zhang, Rui-hao
Yu, De-chen
Gao, Xi-dan
Shi, Jin-tao
Zhang, Kai
Li, Shao-long
Song, Peng-jie
Wang, Ke-ping
Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy
title Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy
title_full Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy
title_fullStr Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy
title_full_unstemmed Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy
title_short Targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy
title_sort targeted therapy for intervertebral disc degeneration: inhibiting apoptosis is a promising treatment strategy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241771/
https://www.ncbi.nlm.nih.gov/pubmed/34220308
http://dx.doi.org/10.7150/ijms.59171
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