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TRIM21 Polymorphisms are associated with Susceptibility and Clinical Status of Oral Squamous Cell Carcinoma patients

Squamous cell cancer of head and neck (HNSCC) is the sixth most common malignancy worldwide. One of the most common HNSCC types is oral squamous cell carcinoma (OSCC), which is the fifth leading cause of cancer death in Taiwan. Tripartite motif 21 (TRIM21) has been reported to play an important role...

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Autores principales: Chuang, Chun-Yi, Chien, Yi-Chung, Lin, Chiao-Wen, Chou, Chia-Hsuan, Chen, Shuo-Chueh, Liu, Chun-Lin, Bai, Li-Yuan, Yang, Shun-Fa, Yu, Yung-Luen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241778/
https://www.ncbi.nlm.nih.gov/pubmed/34220328
http://dx.doi.org/10.7150/ijms.56614
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author Chuang, Chun-Yi
Chien, Yi-Chung
Lin, Chiao-Wen
Chou, Chia-Hsuan
Chen, Shuo-Chueh
Liu, Chun-Lin
Bai, Li-Yuan
Yang, Shun-Fa
Yu, Yung-Luen
author_facet Chuang, Chun-Yi
Chien, Yi-Chung
Lin, Chiao-Wen
Chou, Chia-Hsuan
Chen, Shuo-Chueh
Liu, Chun-Lin
Bai, Li-Yuan
Yang, Shun-Fa
Yu, Yung-Luen
author_sort Chuang, Chun-Yi
collection PubMed
description Squamous cell cancer of head and neck (HNSCC) is the sixth most common malignancy worldwide. One of the most common HNSCC types is oral squamous cell carcinoma (OSCC), which is the fifth leading cause of cancer death in Taiwan. Tripartite motif 21 (TRIM21) has been reported to play an important role in different cancer types. We found a correlation between TRIM21 and survival of HNSCC patients, but little information exists about how altered TRIM21 expression contributes to tumorigenesis. Thus, we investigated the combined effect of TRIM21 polymorphisms and exposure to environmental carcinogens on the susceptibility and clinicopathological characteristics of OSCC. Two single-nucleotide polymorphisms (SNPs) of TRIM21 (rs4144331, rs915956) from 1194 healthy controls and 1192 OSCC patients were analyzed by real-time PCR. Among 1632 smokers, TRIM21 polymorphism carriers with the betel-nut chewing habit had a ~4.8-fold greater risk of OSCC than TRIM21 wild-type carriers without the betel-nut chewing habit. After adjusting for other covariants, OSCC patients with G/T at TRIM21 rs4144331 had a high risk for distant metastasis compared with G/G homozygotes. This study is the first to examine the risk factors associated with TRIM21 SNPs in OSCC progression and development. Thus, our findings suggest that this study is the first to examine the risk factors associated with TRIM21 SNPs in OSCC progression and development and suggest that interactions between mutant genes may alter the susceptibility to OSCC.
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spelling pubmed-82417782021-07-01 TRIM21 Polymorphisms are associated with Susceptibility and Clinical Status of Oral Squamous Cell Carcinoma patients Chuang, Chun-Yi Chien, Yi-Chung Lin, Chiao-Wen Chou, Chia-Hsuan Chen, Shuo-Chueh Liu, Chun-Lin Bai, Li-Yuan Yang, Shun-Fa Yu, Yung-Luen Int J Med Sci Research Paper Squamous cell cancer of head and neck (HNSCC) is the sixth most common malignancy worldwide. One of the most common HNSCC types is oral squamous cell carcinoma (OSCC), which is the fifth leading cause of cancer death in Taiwan. Tripartite motif 21 (TRIM21) has been reported to play an important role in different cancer types. We found a correlation between TRIM21 and survival of HNSCC patients, but little information exists about how altered TRIM21 expression contributes to tumorigenesis. Thus, we investigated the combined effect of TRIM21 polymorphisms and exposure to environmental carcinogens on the susceptibility and clinicopathological characteristics of OSCC. Two single-nucleotide polymorphisms (SNPs) of TRIM21 (rs4144331, rs915956) from 1194 healthy controls and 1192 OSCC patients were analyzed by real-time PCR. Among 1632 smokers, TRIM21 polymorphism carriers with the betel-nut chewing habit had a ~4.8-fold greater risk of OSCC than TRIM21 wild-type carriers without the betel-nut chewing habit. After adjusting for other covariants, OSCC patients with G/T at TRIM21 rs4144331 had a high risk for distant metastasis compared with G/G homozygotes. This study is the first to examine the risk factors associated with TRIM21 SNPs in OSCC progression and development. Thus, our findings suggest that this study is the first to examine the risk factors associated with TRIM21 SNPs in OSCC progression and development and suggest that interactions between mutant genes may alter the susceptibility to OSCC. Ivyspring International Publisher 2021-06-11 /pmc/articles/PMC8241778/ /pubmed/34220328 http://dx.doi.org/10.7150/ijms.56614 Text en © The author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Chuang, Chun-Yi
Chien, Yi-Chung
Lin, Chiao-Wen
Chou, Chia-Hsuan
Chen, Shuo-Chueh
Liu, Chun-Lin
Bai, Li-Yuan
Yang, Shun-Fa
Yu, Yung-Luen
TRIM21 Polymorphisms are associated with Susceptibility and Clinical Status of Oral Squamous Cell Carcinoma patients
title TRIM21 Polymorphisms are associated with Susceptibility and Clinical Status of Oral Squamous Cell Carcinoma patients
title_full TRIM21 Polymorphisms are associated with Susceptibility and Clinical Status of Oral Squamous Cell Carcinoma patients
title_fullStr TRIM21 Polymorphisms are associated with Susceptibility and Clinical Status of Oral Squamous Cell Carcinoma patients
title_full_unstemmed TRIM21 Polymorphisms are associated with Susceptibility and Clinical Status of Oral Squamous Cell Carcinoma patients
title_short TRIM21 Polymorphisms are associated with Susceptibility and Clinical Status of Oral Squamous Cell Carcinoma patients
title_sort trim21 polymorphisms are associated with susceptibility and clinical status of oral squamous cell carcinoma patients
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241778/
https://www.ncbi.nlm.nih.gov/pubmed/34220328
http://dx.doi.org/10.7150/ijms.56614
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