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Serum neurofilament light chain as a severity marker for spinocerebellar ataxia
Since the serum neurofilament light (NfL) chain is known as a promising biomarker in neurodegenerative diseases, we aimed to evaluate serum NfL as a biomarker indicating neuronal damage in autosomal-dominant (AD) spinocerebellar ataxia (SCA). We reviewed patients diagnosed with AD SCA in the outpati...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241827/ https://www.ncbi.nlm.nih.gov/pubmed/34188109 http://dx.doi.org/10.1038/s41598-021-92855-z |
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author | Shin, Hye-Rim Moon, Jangsup Lee, Woo-Jin Lee, Han Sang Kim, Eun Young Shin, Seoyi Lee, Soon-Tae Jung, Keun-Hwa Park, Kyung-Il Jung, Ki-Young Lee, Sang Kun Chu, Kon |
author_facet | Shin, Hye-Rim Moon, Jangsup Lee, Woo-Jin Lee, Han Sang Kim, Eun Young Shin, Seoyi Lee, Soon-Tae Jung, Keun-Hwa Park, Kyung-Il Jung, Ki-Young Lee, Sang Kun Chu, Kon |
author_sort | Shin, Hye-Rim |
collection | PubMed |
description | Since the serum neurofilament light (NfL) chain is known as a promising biomarker in neurodegenerative diseases, we aimed to evaluate serum NfL as a biomarker indicating neuronal damage in autosomal-dominant (AD) spinocerebellar ataxia (SCA). We reviewed patients diagnosed with AD SCA in the outpatient clinic of Seoul National University Hospital’s (SNUH) Department of Neurology between May and August of 2019. We reviewed the demographic data, clinical characteristics, Scale for the Assessment and Rating of Ataxia (SARA) score, and brain magnetic resonance imaging (MRI) scans. The serum NfL was measured by electrochemiluminescence (ECL) immunoassay. Forty-nine patients with AD SCA were reviewed and their serum NfL level was determined. The median serum NfL level (109.5 pg/mL) was higher than control (41.1 pg/mL) (p-value < 0.001). Among the AD SCA patients, there was a positive correlation between the serum NfL level and the trinucleotide repeat number (r = 0.47, p-value = 0.001), disease duration (r = 0.35, p-value = 0.019), disease duration/age × trinucleotide repeat number (r = 0.330, p-value = 0.021), and SARA score (n = 33; r = 0.37, p-value = 0.033). This study shows that serum NfL is elevated in AD SCA patients and correlates with clinical severity. |
format | Online Article Text |
id | pubmed-8241827 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-82418272021-07-06 Serum neurofilament light chain as a severity marker for spinocerebellar ataxia Shin, Hye-Rim Moon, Jangsup Lee, Woo-Jin Lee, Han Sang Kim, Eun Young Shin, Seoyi Lee, Soon-Tae Jung, Keun-Hwa Park, Kyung-Il Jung, Ki-Young Lee, Sang Kun Chu, Kon Sci Rep Article Since the serum neurofilament light (NfL) chain is known as a promising biomarker in neurodegenerative diseases, we aimed to evaluate serum NfL as a biomarker indicating neuronal damage in autosomal-dominant (AD) spinocerebellar ataxia (SCA). We reviewed patients diagnosed with AD SCA in the outpatient clinic of Seoul National University Hospital’s (SNUH) Department of Neurology between May and August of 2019. We reviewed the demographic data, clinical characteristics, Scale for the Assessment and Rating of Ataxia (SARA) score, and brain magnetic resonance imaging (MRI) scans. The serum NfL was measured by electrochemiluminescence (ECL) immunoassay. Forty-nine patients with AD SCA were reviewed and their serum NfL level was determined. The median serum NfL level (109.5 pg/mL) was higher than control (41.1 pg/mL) (p-value < 0.001). Among the AD SCA patients, there was a positive correlation between the serum NfL level and the trinucleotide repeat number (r = 0.47, p-value = 0.001), disease duration (r = 0.35, p-value = 0.019), disease duration/age × trinucleotide repeat number (r = 0.330, p-value = 0.021), and SARA score (n = 33; r = 0.37, p-value = 0.033). This study shows that serum NfL is elevated in AD SCA patients and correlates with clinical severity. Nature Publishing Group UK 2021-06-29 /pmc/articles/PMC8241827/ /pubmed/34188109 http://dx.doi.org/10.1038/s41598-021-92855-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Shin, Hye-Rim Moon, Jangsup Lee, Woo-Jin Lee, Han Sang Kim, Eun Young Shin, Seoyi Lee, Soon-Tae Jung, Keun-Hwa Park, Kyung-Il Jung, Ki-Young Lee, Sang Kun Chu, Kon Serum neurofilament light chain as a severity marker for spinocerebellar ataxia |
title | Serum neurofilament light chain as a severity marker for spinocerebellar ataxia |
title_full | Serum neurofilament light chain as a severity marker for spinocerebellar ataxia |
title_fullStr | Serum neurofilament light chain as a severity marker for spinocerebellar ataxia |
title_full_unstemmed | Serum neurofilament light chain as a severity marker for spinocerebellar ataxia |
title_short | Serum neurofilament light chain as a severity marker for spinocerebellar ataxia |
title_sort | serum neurofilament light chain as a severity marker for spinocerebellar ataxia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241827/ https://www.ncbi.nlm.nih.gov/pubmed/34188109 http://dx.doi.org/10.1038/s41598-021-92855-z |
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