Fenofibrate promotes PPARα-targeted recovery of the intestinal epithelial barrier at the host-microbe interface in dogs with diabetes mellitus

Diabetes mellitus (DM) is associated with a dysfunctional intestinal barrier and an increased risk for systemic infection and inflammation in people, though the pathogenic mechanisms leading to this are poorly understood. Using a canine model of DM, we showed that the peroxisomal proliferator-activa...

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Detalles Bibliográficos
Autores principales: Crakes, Katti R., Pires, Jully, Quach, Nina, Ellis-Reis, Riley E., Greathouse, Rachel, Chittum, Kathyrnne A., Steiner, Jörg M., Pesavento, Patricia, Marks, Stanley L., Dandekar, Satya, Gilor, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241862/
https://www.ncbi.nlm.nih.gov/pubmed/34188162
http://dx.doi.org/10.1038/s41598-021-92966-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241862/
https://www.ncbi.nlm.nih.gov/pubmed/34188162
http://dx.doi.org/10.1038/s41598-021-92966-7

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