NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia

In a recent issue of Science Advances, Srivastava et al. report a novel nucleotide biosynthesis regulatory role for UBR7 in NOTCH1-driven T-ALL. Here we will discuss their key findings and the implications for using cancer metabolism to understand the development and progression of T-ALL.

Detalles Bibliográficos
Autor principal: Volk, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241981/
https://www.ncbi.nlm.nih.gov/pubmed/34188174
http://dx.doi.org/10.1038/s42003-021-02330-8
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author Volk, Andrew
author_facet Volk, Andrew
author_sort Volk, Andrew
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description In a recent issue of Science Advances, Srivastava et al. report a novel nucleotide biosynthesis regulatory role for UBR7 in NOTCH1-driven T-ALL. Here we will discuss their key findings and the implications for using cancer metabolism to understand the development and progression of T-ALL.
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spelling pubmed-82419812021-07-20 NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia Volk, Andrew Commun Biol Comment In a recent issue of Science Advances, Srivastava et al. report a novel nucleotide biosynthesis regulatory role for UBR7 in NOTCH1-driven T-ALL. Here we will discuss their key findings and the implications for using cancer metabolism to understand the development and progression of T-ALL. Nature Publishing Group UK 2021-06-29 /pmc/articles/PMC8241981/ /pubmed/34188174 http://dx.doi.org/10.1038/s42003-021-02330-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Volk, Andrew
NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia
title NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia
title_full NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia
title_fullStr NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia
title_full_unstemmed NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia
title_short NOTCH-ing up nucleotide metabolism in T-cell acute lymphoblastic leukemia
title_sort notch-ing up nucleotide metabolism in t-cell acute lymphoblastic leukemia
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241981/
https://www.ncbi.nlm.nih.gov/pubmed/34188174
http://dx.doi.org/10.1038/s42003-021-02330-8
work_keys_str_mv AT volkandrew notchingupnucleotidemetabolismintcellacutelymphoblasticleukemia

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