Overlapping regions of Caf20 mediate its interactions with the mRNA-5′cap-binding protein eIF4E and with ribosomes

By interacting with the mRNA 5′ cap, the translation initiation factor eIF4E plays a critical role in selecting mRNAs for protein synthesis in eukaryotic cells. Caf20 is a member of the family of proteins found across eukaryotes termed 4E-BPs, which compete with eIF4G for interaction with eIF4E. Caf...

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Detalles Bibliográficos
Autores principales: Nwokoye, Ebelechukwu C., AlNaseem, Eiman, Crawford, Robert A., Castelli, Lydia M., Jennings, Martin D., Kershaw, Christopher J., Pavitt, Graham D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242001/
https://www.ncbi.nlm.nih.gov/pubmed/34188131
http://dx.doi.org/10.1038/s41598-021-92931-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242001/
https://www.ncbi.nlm.nih.gov/pubmed/34188131
http://dx.doi.org/10.1038/s41598-021-92931-4

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