SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4(+) T cells

Host lipid metabolism and viral responses are intimately connected. However, the process by which the acquired immune systems adapts lipid metabolism to meet demands, and whether or not the metabolic rewiring confers a selective advantage to host immunity, remains unclear. Here we show that viral in...

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Detalles Bibliográficos
Autores principales: Kanno, Toshio, Nakajima, Takahiro, Yokoyama, Satoru, Asou, Hikari K., Sasamoto, Shigemi, Kamii, Yasuhiro, Hayashizaki, Koji, Ouchi, Yasuo, Onodera, Taishi, Takahashi, Yoshimasa, Ikeda, Kazutaka, Hasegawa, Yoshinori, Kinjo, Yuki, Ohara, Osamu, Nakayama, Toshinori, Endo, Yusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242023/
https://www.ncbi.nlm.nih.gov/pubmed/34188173
http://dx.doi.org/10.1038/s42003-021-02310-y

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