De novo deoxyribonucleotide biosynthesis regulates cell growth and tumor progression in small-cell lung carcinoma

Deoxyribonucleotide biosynthesis from ribonucleotides supports the growth of active cancer cells by producing building blocks for DNA. Although ribonucleotide reductase (RNR) is known to catalyze the rate-limiting step of de novo deoxyribonucleotide triphosphate (dNTP) synthesis, the biological func...

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Detalles Bibliográficos
Autores principales: Maruyama, Ami, Sato, Yuzo, Nakayama, Joji, Murai, Junko, Ishikawa, Takamasa, Soga, Tomoyoshi, Makinoshima, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242079/
https://www.ncbi.nlm.nih.gov/pubmed/34188151
http://dx.doi.org/10.1038/s41598-021-92948-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242079/
https://www.ncbi.nlm.nih.gov/pubmed/34188151
http://dx.doi.org/10.1038/s41598-021-92948-9

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