Cargando…

Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair

Numerous cellular processes, including toxic protein aggregation and oxidative stress, have been studied extensively as potential mechanisms underlying neurodegeneration. However, limited therapeutic efficacy targeting these processes has prompted other mechanisms to be explored. Previous research h...

Descripción completa

Detalles Bibliográficos
Autores principales: Leung, Emily, Hazrati, Lili-Naz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242133/
https://www.ncbi.nlm.nih.gov/pubmed/34222870
http://dx.doi.org/10.1093/braincomms/fcab117
_version_ 1783715565386334208
author Leung, Emily
Hazrati, Lili-Naz
author_facet Leung, Emily
Hazrati, Lili-Naz
author_sort Leung, Emily
collection PubMed
description Numerous cellular processes, including toxic protein aggregation and oxidative stress, have been studied extensively as potential mechanisms underlying neurodegeneration. However, limited therapeutic efficacy targeting these processes has prompted other mechanisms to be explored. Previous research has emphasized a link between cellular senescence and neurodegeneration, where senescence induced by excess DNA damage and deficient DNA repair results in structural and functional changes that ultimately contribute to brain dysfunction and increased vulnerability for neurodegeneration. Specific DNA repair proteins, such as breast cancer type 1, have been associated with both stress-induced senescence and neurodegenerative diseases, however, specific mechanisms remain unclear. Therefore, this review explores DNA damage-induced senescence in the brain as a driver of neurodegeneration, with particular focus on breast cancer type 1, and its potential contribution to sex-specific differences associated with neurodegenerative disease.
format Online
Article
Text
id pubmed-8242133
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-82421332021-07-01 Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair Leung, Emily Hazrati, Lili-Naz Brain Commun Review Article Numerous cellular processes, including toxic protein aggregation and oxidative stress, have been studied extensively as potential mechanisms underlying neurodegeneration. However, limited therapeutic efficacy targeting these processes has prompted other mechanisms to be explored. Previous research has emphasized a link between cellular senescence and neurodegeneration, where senescence induced by excess DNA damage and deficient DNA repair results in structural and functional changes that ultimately contribute to brain dysfunction and increased vulnerability for neurodegeneration. Specific DNA repair proteins, such as breast cancer type 1, have been associated with both stress-induced senescence and neurodegenerative diseases, however, specific mechanisms remain unclear. Therefore, this review explores DNA damage-induced senescence in the brain as a driver of neurodegeneration, with particular focus on breast cancer type 1, and its potential contribution to sex-specific differences associated with neurodegenerative disease. Oxford University Press 2021-05-27 /pmc/articles/PMC8242133/ /pubmed/34222870 http://dx.doi.org/10.1093/braincomms/fcab117 Text en © The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Leung, Emily
Hazrati, Lili-Naz
Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair
title Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair
title_full Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair
title_fullStr Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair
title_full_unstemmed Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair
title_short Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair
title_sort breast cancer type 1 and neurodegeneration: consequences of deficient dna repair
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242133/
https://www.ncbi.nlm.nih.gov/pubmed/34222870
http://dx.doi.org/10.1093/braincomms/fcab117
work_keys_str_mv AT leungemily breastcancertype1andneurodegenerationconsequencesofdeficientdnarepair
AT hazratililinaz breastcancertype1andneurodegenerationconsequencesofdeficientdnarepair