Cargando…
Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair
Numerous cellular processes, including toxic protein aggregation and oxidative stress, have been studied extensively as potential mechanisms underlying neurodegeneration. However, limited therapeutic efficacy targeting these processes has prompted other mechanisms to be explored. Previous research h...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242133/ https://www.ncbi.nlm.nih.gov/pubmed/34222870 http://dx.doi.org/10.1093/braincomms/fcab117 |
_version_ | 1783715565386334208 |
---|---|
author | Leung, Emily Hazrati, Lili-Naz |
author_facet | Leung, Emily Hazrati, Lili-Naz |
author_sort | Leung, Emily |
collection | PubMed |
description | Numerous cellular processes, including toxic protein aggregation and oxidative stress, have been studied extensively as potential mechanisms underlying neurodegeneration. However, limited therapeutic efficacy targeting these processes has prompted other mechanisms to be explored. Previous research has emphasized a link between cellular senescence and neurodegeneration, where senescence induced by excess DNA damage and deficient DNA repair results in structural and functional changes that ultimately contribute to brain dysfunction and increased vulnerability for neurodegeneration. Specific DNA repair proteins, such as breast cancer type 1, have been associated with both stress-induced senescence and neurodegenerative diseases, however, specific mechanisms remain unclear. Therefore, this review explores DNA damage-induced senescence in the brain as a driver of neurodegeneration, with particular focus on breast cancer type 1, and its potential contribution to sex-specific differences associated with neurodegenerative disease. |
format | Online Article Text |
id | pubmed-8242133 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-82421332021-07-01 Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair Leung, Emily Hazrati, Lili-Naz Brain Commun Review Article Numerous cellular processes, including toxic protein aggregation and oxidative stress, have been studied extensively as potential mechanisms underlying neurodegeneration. However, limited therapeutic efficacy targeting these processes has prompted other mechanisms to be explored. Previous research has emphasized a link between cellular senescence and neurodegeneration, where senescence induced by excess DNA damage and deficient DNA repair results in structural and functional changes that ultimately contribute to brain dysfunction and increased vulnerability for neurodegeneration. Specific DNA repair proteins, such as breast cancer type 1, have been associated with both stress-induced senescence and neurodegenerative diseases, however, specific mechanisms remain unclear. Therefore, this review explores DNA damage-induced senescence in the brain as a driver of neurodegeneration, with particular focus on breast cancer type 1, and its potential contribution to sex-specific differences associated with neurodegenerative disease. Oxford University Press 2021-05-27 /pmc/articles/PMC8242133/ /pubmed/34222870 http://dx.doi.org/10.1093/braincomms/fcab117 Text en © The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Leung, Emily Hazrati, Lili-Naz Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair |
title | Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair |
title_full | Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair |
title_fullStr | Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair |
title_full_unstemmed | Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair |
title_short | Breast cancer type 1 and neurodegeneration: consequences of deficient DNA repair |
title_sort | breast cancer type 1 and neurodegeneration: consequences of deficient dna repair |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242133/ https://www.ncbi.nlm.nih.gov/pubmed/34222870 http://dx.doi.org/10.1093/braincomms/fcab117 |
work_keys_str_mv | AT leungemily breastcancertype1andneurodegenerationconsequencesofdeficientdnarepair AT hazratililinaz breastcancertype1andneurodegenerationconsequencesofdeficientdnarepair |