Generation of a Mouse Model to Study the Noonan Syndrome Gene Lztr1 in the Telencephalon

The leucine zipper-like transcriptional regulator 1 (Lztr1) is a BTB-Kelch domain protein involved in RAS/MAPK pathway regulation. Mutations in LZTR1 are associated with cancers and Noonan syndrome, the most common RASopathy. The expression and function of Lztr1 in the developing brain remains poorl...

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Detalles Bibliográficos
Autores principales: Talley, Mary Jo, Nardini, Diana, Shabbir, Nisha, Ehrman, Lisa A., Prada, Carlos E., Waclaw, Ronald R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242193/
https://www.ncbi.nlm.nih.gov/pubmed/34222248
http://dx.doi.org/10.3389/fcell.2021.673995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242193/
https://www.ncbi.nlm.nih.gov/pubmed/34222248
http://dx.doi.org/10.3389/fcell.2021.673995

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