Cargando…

The Angiotensin-Converting Enzyme Inhibitory State Promotes the Transformation of Non-Small Cell Lung Cancer Blood Supply Pattern Toward Vasculogenic Mimicry Formation

Tumor microenvironment plays an important role in tumor proliferation, metastasis, and angiogenesis. Local RAS is a key factor to tumor proliferation and metastasis in NSCLC microenvironment, but its role on angiogenesis and VM formation remains unclear. Although overwhelming majority of previous st...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Kandi, Han, Huize, Luo, Yexin, Ye, Hong, Lin, Hongxia, Ni, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242235/
https://www.ncbi.nlm.nih.gov/pubmed/34221978
http://dx.doi.org/10.3389/fonc.2021.663671
_version_ 1783715589815009280
author Xu, Kandi
Han, Huize
Luo, Yexin
Ye, Hong
Lin, Hongxia
Ni, Lei
author_facet Xu, Kandi
Han, Huize
Luo, Yexin
Ye, Hong
Lin, Hongxia
Ni, Lei
author_sort Xu, Kandi
collection PubMed
description Tumor microenvironment plays an important role in tumor proliferation, metastasis, and angiogenesis. Local RAS is a key factor to tumor proliferation and metastasis in NSCLC microenvironment, but its role on angiogenesis and VM formation remains unclear. Although overwhelming majority of previous studies suggested that VM is well established in aggressive tumor and facilitates tumor growth and metastasis, we put forward different views from another angle. We proved that status of tumor blood supply patterns, including VM channels and endothelial vessels, can dynamically exchange with each other along with local RAS fluctuations in microenvironment. Quantitatively, ACE2/ACEI promotes VM formation via Nodal/Notch4 activation; while structurally, ACE2/ACEI leads to a strong and solid structure of VM via inhibition of VE-cadherin internalization. These changes induced by ACE2/ACEI relate to relatively low metastasis rate and comforting prognoses of NSCLC patients.
format Online
Article
Text
id pubmed-8242235
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-82422352021-07-01 The Angiotensin-Converting Enzyme Inhibitory State Promotes the Transformation of Non-Small Cell Lung Cancer Blood Supply Pattern Toward Vasculogenic Mimicry Formation Xu, Kandi Han, Huize Luo, Yexin Ye, Hong Lin, Hongxia Ni, Lei Front Oncol Oncology Tumor microenvironment plays an important role in tumor proliferation, metastasis, and angiogenesis. Local RAS is a key factor to tumor proliferation and metastasis in NSCLC microenvironment, but its role on angiogenesis and VM formation remains unclear. Although overwhelming majority of previous studies suggested that VM is well established in aggressive tumor and facilitates tumor growth and metastasis, we put forward different views from another angle. We proved that status of tumor blood supply patterns, including VM channels and endothelial vessels, can dynamically exchange with each other along with local RAS fluctuations in microenvironment. Quantitatively, ACE2/ACEI promotes VM formation via Nodal/Notch4 activation; while structurally, ACE2/ACEI leads to a strong and solid structure of VM via inhibition of VE-cadherin internalization. These changes induced by ACE2/ACEI relate to relatively low metastasis rate and comforting prognoses of NSCLC patients. Frontiers Media S.A. 2021-06-16 /pmc/articles/PMC8242235/ /pubmed/34221978 http://dx.doi.org/10.3389/fonc.2021.663671 Text en Copyright © 2021 Xu, Han, Luo, Ye, Lin and Ni https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Xu, Kandi
Han, Huize
Luo, Yexin
Ye, Hong
Lin, Hongxia
Ni, Lei
The Angiotensin-Converting Enzyme Inhibitory State Promotes the Transformation of Non-Small Cell Lung Cancer Blood Supply Pattern Toward Vasculogenic Mimicry Formation
title The Angiotensin-Converting Enzyme Inhibitory State Promotes the Transformation of Non-Small Cell Lung Cancer Blood Supply Pattern Toward Vasculogenic Mimicry Formation
title_full The Angiotensin-Converting Enzyme Inhibitory State Promotes the Transformation of Non-Small Cell Lung Cancer Blood Supply Pattern Toward Vasculogenic Mimicry Formation
title_fullStr The Angiotensin-Converting Enzyme Inhibitory State Promotes the Transformation of Non-Small Cell Lung Cancer Blood Supply Pattern Toward Vasculogenic Mimicry Formation
title_full_unstemmed The Angiotensin-Converting Enzyme Inhibitory State Promotes the Transformation of Non-Small Cell Lung Cancer Blood Supply Pattern Toward Vasculogenic Mimicry Formation
title_short The Angiotensin-Converting Enzyme Inhibitory State Promotes the Transformation of Non-Small Cell Lung Cancer Blood Supply Pattern Toward Vasculogenic Mimicry Formation
title_sort angiotensin-converting enzyme inhibitory state promotes the transformation of non-small cell lung cancer blood supply pattern toward vasculogenic mimicry formation
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242235/
https://www.ncbi.nlm.nih.gov/pubmed/34221978
http://dx.doi.org/10.3389/fonc.2021.663671
work_keys_str_mv AT xukandi theangiotensinconvertingenzymeinhibitorystatepromotesthetransformationofnonsmallcelllungcancerbloodsupplypatterntowardvasculogenicmimicryformation
AT hanhuize theangiotensinconvertingenzymeinhibitorystatepromotesthetransformationofnonsmallcelllungcancerbloodsupplypatterntowardvasculogenicmimicryformation
AT luoyexin theangiotensinconvertingenzymeinhibitorystatepromotesthetransformationofnonsmallcelllungcancerbloodsupplypatterntowardvasculogenicmimicryformation
AT yehong theangiotensinconvertingenzymeinhibitorystatepromotesthetransformationofnonsmallcelllungcancerbloodsupplypatterntowardvasculogenicmimicryformation
AT linhongxia theangiotensinconvertingenzymeinhibitorystatepromotesthetransformationofnonsmallcelllungcancerbloodsupplypatterntowardvasculogenicmimicryformation
AT nilei theangiotensinconvertingenzymeinhibitorystatepromotesthetransformationofnonsmallcelllungcancerbloodsupplypatterntowardvasculogenicmimicryformation
AT xukandi angiotensinconvertingenzymeinhibitorystatepromotesthetransformationofnonsmallcelllungcancerbloodsupplypatterntowardvasculogenicmimicryformation
AT hanhuize angiotensinconvertingenzymeinhibitorystatepromotesthetransformationofnonsmallcelllungcancerbloodsupplypatterntowardvasculogenicmimicryformation
AT luoyexin angiotensinconvertingenzymeinhibitorystatepromotesthetransformationofnonsmallcelllungcancerbloodsupplypatterntowardvasculogenicmimicryformation
AT yehong angiotensinconvertingenzymeinhibitorystatepromotesthetransformationofnonsmallcelllungcancerbloodsupplypatterntowardvasculogenicmimicryformation
AT linhongxia angiotensinconvertingenzymeinhibitorystatepromotesthetransformationofnonsmallcelllungcancerbloodsupplypatterntowardvasculogenicmimicryformation
AT nilei angiotensinconvertingenzymeinhibitorystatepromotesthetransformationofnonsmallcelllungcancerbloodsupplypatterntowardvasculogenicmimicryformation