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Clinical Characteristics and Prognosis of Renal Cell Carcinoma With Spinal Bone Metastases

BACKGROUND: The prognosis of renal cell carcinoma (RCC) with spinal bone metastasis (sBM) varies greatly. In this study, we aimed to define the clinical characteristics and prognostic factors of RCC with spinal bone metastasis (sBM) in our center. METHODS: The clinical and medical records of RCC pat...

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Autores principales: Zhai, Jianpo, Liu, Ning, Wang, Hai, Huang, Guanglin, Man, Libo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242338/
https://www.ncbi.nlm.nih.gov/pubmed/34221976
http://dx.doi.org/10.3389/fonc.2021.659779
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author Zhai, Jianpo
Liu, Ning
Wang, Hai
Huang, Guanglin
Man, Libo
author_facet Zhai, Jianpo
Liu, Ning
Wang, Hai
Huang, Guanglin
Man, Libo
author_sort Zhai, Jianpo
collection PubMed
description BACKGROUND: The prognosis of renal cell carcinoma (RCC) with spinal bone metastasis (sBM) varies greatly. In this study, we aimed to define the clinical characteristics and prognostic factors of RCC with spinal bone metastasis (sBM) in our center. METHODS: The clinical and medical records of RCC patients with sBMs were collected. The gender, age, time of BM, the extent of BM, the number of BMs, the presence or absence of visceral metastasis, and the pathological type of BM were investigated. All patients were followed up regularly. Overall survival (OS) was calculated from the date of BMs diagnosis to death or last follow-up using Kaplan-Meier method and modelled with Cox regression analysis. RESULTS: Forty-three RCC patients with sBM were collected. sBM was found synchronously in 30 patients (70%) and metachronously in 13 patients (30%). The median survival time was 30 months in 13 patients (30%) with solitary sBM and 19 months in 30 patients (70%) with multiple sBMs (P = 0.002). Visceral metastasis occurred in 12 patients (28%) with the median survival time of 17 months, while the other 31 patients (72%) had no visceral metastasis with the median survival time of 29 months (P<0.001). En-block resection was done in 10 patients with median survival time of 40.1 months. Non-en-block resection were done in 33 patients with median survival time of 19.7 months (P<0.001). Multivariate COX regression analysis showed that MSKCC score, number of BM, visceral metastasis, and en-block resection are the independent prognosis factors of RCC patients with sBM. CONCLUSIONS: MSKCC risk stratification, number of sBM, visceral metastasis and en-block resection are significant prognostic factors for OS in RCC patients with spinal BM. Therefore, for selected patients who has solitary spinal BM with no visceral metastasis, en-block resection of spinal BM can potentially prolong survival and is the treatment of choice.
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spelling pubmed-82423382021-07-01 Clinical Characteristics and Prognosis of Renal Cell Carcinoma With Spinal Bone Metastases Zhai, Jianpo Liu, Ning Wang, Hai Huang, Guanglin Man, Libo Front Oncol Oncology BACKGROUND: The prognosis of renal cell carcinoma (RCC) with spinal bone metastasis (sBM) varies greatly. In this study, we aimed to define the clinical characteristics and prognostic factors of RCC with spinal bone metastasis (sBM) in our center. METHODS: The clinical and medical records of RCC patients with sBMs were collected. The gender, age, time of BM, the extent of BM, the number of BMs, the presence or absence of visceral metastasis, and the pathological type of BM were investigated. All patients were followed up regularly. Overall survival (OS) was calculated from the date of BMs diagnosis to death or last follow-up using Kaplan-Meier method and modelled with Cox regression analysis. RESULTS: Forty-three RCC patients with sBM were collected. sBM was found synchronously in 30 patients (70%) and metachronously in 13 patients (30%). The median survival time was 30 months in 13 patients (30%) with solitary sBM and 19 months in 30 patients (70%) with multiple sBMs (P = 0.002). Visceral metastasis occurred in 12 patients (28%) with the median survival time of 17 months, while the other 31 patients (72%) had no visceral metastasis with the median survival time of 29 months (P<0.001). En-block resection was done in 10 patients with median survival time of 40.1 months. Non-en-block resection were done in 33 patients with median survival time of 19.7 months (P<0.001). Multivariate COX regression analysis showed that MSKCC score, number of BM, visceral metastasis, and en-block resection are the independent prognosis factors of RCC patients with sBM. CONCLUSIONS: MSKCC risk stratification, number of sBM, visceral metastasis and en-block resection are significant prognostic factors for OS in RCC patients with spinal BM. Therefore, for selected patients who has solitary spinal BM with no visceral metastasis, en-block resection of spinal BM can potentially prolong survival and is the treatment of choice. Frontiers Media S.A. 2021-06-16 /pmc/articles/PMC8242338/ /pubmed/34221976 http://dx.doi.org/10.3389/fonc.2021.659779 Text en Copyright © 2021 Zhai, Liu, Wang, Huang and Man https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhai, Jianpo
Liu, Ning
Wang, Hai
Huang, Guanglin
Man, Libo
Clinical Characteristics and Prognosis of Renal Cell Carcinoma With Spinal Bone Metastases
title Clinical Characteristics and Prognosis of Renal Cell Carcinoma With Spinal Bone Metastases
title_full Clinical Characteristics and Prognosis of Renal Cell Carcinoma With Spinal Bone Metastases
title_fullStr Clinical Characteristics and Prognosis of Renal Cell Carcinoma With Spinal Bone Metastases
title_full_unstemmed Clinical Characteristics and Prognosis of Renal Cell Carcinoma With Spinal Bone Metastases
title_short Clinical Characteristics and Prognosis of Renal Cell Carcinoma With Spinal Bone Metastases
title_sort clinical characteristics and prognosis of renal cell carcinoma with spinal bone metastases
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242338/
https://www.ncbi.nlm.nih.gov/pubmed/34221976
http://dx.doi.org/10.3389/fonc.2021.659779
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