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Cardiac Safety of Kinase Inhibitors – Improving Understanding and Prediction of Liabilities in Drug Discovery Using Human Stem Cell-Derived Models

Many small molecule kinase inhibitors (SMKIs) used to fight cancer have been associated with cardiotoxicity in the clinic. Therefore, preventing their failure in clinical development is a priority for preclinical discovery. Our study focused on the integration and concurrent measurement of ATP, apop...

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Detalles Bibliográficos
Autores principales:	Ziegler, Ricarda, Häusermann, Fabian, Kirchner, Stephan, Polonchuk, Liudmila
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242589/ https://www.ncbi.nlm.nih.gov/pubmed/34222360 http://dx.doi.org/10.3389/fcvm.2021.639824

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