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Obesity and its implications on cerebral circulation and intracranial compliance in severe COVID‐19

OBJECTIVE: Multiple factors have been identified as causes of intracranial compliance impairment (ICCI) among patients with obesity. On the other hand, obesity has been linked with worst outcomes in COVID‐19. Thus, the hypothesis of severe acute respiratory syndrome (SARS) conducing to cerebral hemo...

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Autores principales: Brasil, Sérgio, Renck, Alessandra Covallero, Taccone, Fabio Silvio, Fontoura Solla, Davi Jorge, Tomazini, Bruno Martins, Wayhs, Sâmia Yasin, Fonseca, Sérgio, Bassi, Estevão, Lucena, Bruno, De Carvalho Nogueira, Ricardo, Paiva, Wellingson, Teixeira, Manoel Jacobsen, Frade Costa, Elaine Maria, Sá Malbouisson, Luiz Marcelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242615/
https://www.ncbi.nlm.nih.gov/pubmed/34226849
http://dx.doi.org/10.1002/osp4.534
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author Brasil, Sérgio
Renck, Alessandra Covallero
Taccone, Fabio Silvio
Fontoura Solla, Davi Jorge
Tomazini, Bruno Martins
Wayhs, Sâmia Yasin
Fonseca, Sérgio
Bassi, Estevão
Lucena, Bruno
De Carvalho Nogueira, Ricardo
Paiva, Wellingson
Teixeira, Manoel Jacobsen
Frade Costa, Elaine Maria
Sá Malbouisson, Luiz Marcelo
author_facet Brasil, Sérgio
Renck, Alessandra Covallero
Taccone, Fabio Silvio
Fontoura Solla, Davi Jorge
Tomazini, Bruno Martins
Wayhs, Sâmia Yasin
Fonseca, Sérgio
Bassi, Estevão
Lucena, Bruno
De Carvalho Nogueira, Ricardo
Paiva, Wellingson
Teixeira, Manoel Jacobsen
Frade Costa, Elaine Maria
Sá Malbouisson, Luiz Marcelo
author_sort Brasil, Sérgio
collection PubMed
description OBJECTIVE: Multiple factors have been identified as causes of intracranial compliance impairment (ICCI) among patients with obesity. On the other hand, obesity has been linked with worst outcomes in COVID‐19. Thus, the hypothesis of severe acute respiratory syndrome (SARS) conducing to cerebral hemodynamic disorders (CHD) able to worsen ICCI and play an additional role on prognosis determination for COVID‐19 among obese patients becomes suitable. METHODS: 50 cases of SARS by COVID‐19 were evaluated, for the presence of ICCI and cerebrovascular circulatory disturbances in correspondence with whether unfavorable outcomes (death or impossibility for mechanical ventilation weaning [MVW]) within 7 days after evaluation. The objective was to observe whether obese patients (BMI ≥ 30) disclosed worse outcomes and tests results compared with lean subjects with same clinical background. RESULTS: 23 (46%) patients among 50 had obesity. ICCI was verified in 18 (78%) obese, whereas in 13 (48%) of 27 non‐obese (p = 0,029). CHD were not significantly different between groups, despite being high prevalent in both. 69% unfavorable outcomes were observed among obese and 44% for lean subjects (p = 0,075). CONCLUSION: In the present study, intracranial compliance impairment was significantly more observed among obese subjects and may have contributed for SARS COVID‐19 worsen prognosis.
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spelling pubmed-82426152021-07-01 Obesity and its implications on cerebral circulation and intracranial compliance in severe COVID‐19 Brasil, Sérgio Renck, Alessandra Covallero Taccone, Fabio Silvio Fontoura Solla, Davi Jorge Tomazini, Bruno Martins Wayhs, Sâmia Yasin Fonseca, Sérgio Bassi, Estevão Lucena, Bruno De Carvalho Nogueira, Ricardo Paiva, Wellingson Teixeira, Manoel Jacobsen Frade Costa, Elaine Maria Sá Malbouisson, Luiz Marcelo Obes Sci Pract Original Articles OBJECTIVE: Multiple factors have been identified as causes of intracranial compliance impairment (ICCI) among patients with obesity. On the other hand, obesity has been linked with worst outcomes in COVID‐19. Thus, the hypothesis of severe acute respiratory syndrome (SARS) conducing to cerebral hemodynamic disorders (CHD) able to worsen ICCI and play an additional role on prognosis determination for COVID‐19 among obese patients becomes suitable. METHODS: 50 cases of SARS by COVID‐19 were evaluated, for the presence of ICCI and cerebrovascular circulatory disturbances in correspondence with whether unfavorable outcomes (death or impossibility for mechanical ventilation weaning [MVW]) within 7 days after evaluation. The objective was to observe whether obese patients (BMI ≥ 30) disclosed worse outcomes and tests results compared with lean subjects with same clinical background. RESULTS: 23 (46%) patients among 50 had obesity. ICCI was verified in 18 (78%) obese, whereas in 13 (48%) of 27 non‐obese (p = 0,029). CHD were not significantly different between groups, despite being high prevalent in both. 69% unfavorable outcomes were observed among obese and 44% for lean subjects (p = 0,075). CONCLUSION: In the present study, intracranial compliance impairment was significantly more observed among obese subjects and may have contributed for SARS COVID‐19 worsen prognosis. John Wiley and Sons Inc. 2021-05-27 /pmc/articles/PMC8242615/ /pubmed/34226849 http://dx.doi.org/10.1002/osp4.534 Text en © 2021 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Brasil, Sérgio
Renck, Alessandra Covallero
Taccone, Fabio Silvio
Fontoura Solla, Davi Jorge
Tomazini, Bruno Martins
Wayhs, Sâmia Yasin
Fonseca, Sérgio
Bassi, Estevão
Lucena, Bruno
De Carvalho Nogueira, Ricardo
Paiva, Wellingson
Teixeira, Manoel Jacobsen
Frade Costa, Elaine Maria
Sá Malbouisson, Luiz Marcelo
Obesity and its implications on cerebral circulation and intracranial compliance in severe COVID‐19
title Obesity and its implications on cerebral circulation and intracranial compliance in severe COVID‐19
title_full Obesity and its implications on cerebral circulation and intracranial compliance in severe COVID‐19
title_fullStr Obesity and its implications on cerebral circulation and intracranial compliance in severe COVID‐19
title_full_unstemmed Obesity and its implications on cerebral circulation and intracranial compliance in severe COVID‐19
title_short Obesity and its implications on cerebral circulation and intracranial compliance in severe COVID‐19
title_sort obesity and its implications on cerebral circulation and intracranial compliance in severe covid‐19
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242615/
https://www.ncbi.nlm.nih.gov/pubmed/34226849
http://dx.doi.org/10.1002/osp4.534
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