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Amplitude Growth Functions of Auditory Nerve Responses to Electric Pulse Stimulation With Varied Interphase Gaps in Cochlear Implant Users With Ipsilateral Residual Hearing
Amplitude growth functions (AGFs) of electrically evoked compound action potentials (eCAPs) with varying interphase gaps (IPGs) were measured in cochlear implant users with ipsilateral residual hearing (electric-acoustic stimulation [EAS]). It was hypothesized that IPG effects on AGFs provide an obj...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243142/ https://www.ncbi.nlm.nih.gov/pubmed/34181493 http://dx.doi.org/10.1177/23312165211014137 |
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author | Imsiecke, Marina Büchner, Andreas Lenarz, Thomas Nogueira, Waldo |
author_facet | Imsiecke, Marina Büchner, Andreas Lenarz, Thomas Nogueira, Waldo |
author_sort | Imsiecke, Marina |
collection | PubMed |
description | Amplitude growth functions (AGFs) of electrically evoked compound action potentials (eCAPs) with varying interphase gaps (IPGs) were measured in cochlear implant users with ipsilateral residual hearing (electric-acoustic stimulation [EAS]). It was hypothesized that IPG effects on AGFs provide an objective measure to estimate neural health. This hypothesis was tested in EAS users, as residual low-frequency hearing might imply survival of hair cells and hence better neural health in apical compared to basal cochlear regions. A total of 16 MED-EL EAS subjects participated, as well as a control group of 16 deaf cochlear implant users. The IPG effect on the AGF characteristics of slope, threshold, dynamic range, and stimulus level at 50% maximum eCAP amplitude (level(50%)) was investigated. AGF threshold and level(50%) were significantly affected by the IPG in both EAS and control group. The magnitude of AGF characteristics correlated with electrode impedance and electrode-modiolus distance (EMD) in both groups. In contrast, the change of the AGF characteristics with increasing IPG was independent of these electrode-specific measures. The IPG effect on the AGF level(50%) in both groups, as well as on the threshold in EAS users, correlated with the duration of hearing loss, which is a predictor of neural health. In EAS users, a significantly different IPG effect on level(50%) was found between apical and medial electrodes. This outcome is consistent with our hypothesis that the influence of IPG effects on AGF characteristics provides a sensitive measurement and may indicate better neural health in the apex compared to the medial cochlear region in EAS users. |
format | Online Article Text |
id | pubmed-8243142 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-82431422021-07-13 Amplitude Growth Functions of Auditory Nerve Responses to Electric Pulse Stimulation With Varied Interphase Gaps in Cochlear Implant Users With Ipsilateral Residual Hearing Imsiecke, Marina Büchner, Andreas Lenarz, Thomas Nogueira, Waldo Trends Hear 2019 ISAAR special collection: Original Article Amplitude growth functions (AGFs) of electrically evoked compound action potentials (eCAPs) with varying interphase gaps (IPGs) were measured in cochlear implant users with ipsilateral residual hearing (electric-acoustic stimulation [EAS]). It was hypothesized that IPG effects on AGFs provide an objective measure to estimate neural health. This hypothesis was tested in EAS users, as residual low-frequency hearing might imply survival of hair cells and hence better neural health in apical compared to basal cochlear regions. A total of 16 MED-EL EAS subjects participated, as well as a control group of 16 deaf cochlear implant users. The IPG effect on the AGF characteristics of slope, threshold, dynamic range, and stimulus level at 50% maximum eCAP amplitude (level(50%)) was investigated. AGF threshold and level(50%) were significantly affected by the IPG in both EAS and control group. The magnitude of AGF characteristics correlated with electrode impedance and electrode-modiolus distance (EMD) in both groups. In contrast, the change of the AGF characteristics with increasing IPG was independent of these electrode-specific measures. The IPG effect on the AGF level(50%) in both groups, as well as on the threshold in EAS users, correlated with the duration of hearing loss, which is a predictor of neural health. In EAS users, a significantly different IPG effect on level(50%) was found between apical and medial electrodes. This outcome is consistent with our hypothesis that the influence of IPG effects on AGF characteristics provides a sensitive measurement and may indicate better neural health in the apex compared to the medial cochlear region in EAS users. SAGE Publications 2021-06-28 /pmc/articles/PMC8243142/ /pubmed/34181493 http://dx.doi.org/10.1177/23312165211014137 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | 2019 ISAAR special collection: Original Article Imsiecke, Marina Büchner, Andreas Lenarz, Thomas Nogueira, Waldo Amplitude Growth Functions of Auditory Nerve Responses to Electric Pulse Stimulation With Varied Interphase Gaps in Cochlear Implant Users With Ipsilateral Residual Hearing |
title | Amplitude Growth Functions of Auditory Nerve Responses to Electric
Pulse Stimulation With Varied Interphase Gaps in Cochlear Implant Users With
Ipsilateral Residual Hearing |
title_full | Amplitude Growth Functions of Auditory Nerve Responses to Electric
Pulse Stimulation With Varied Interphase Gaps in Cochlear Implant Users With
Ipsilateral Residual Hearing |
title_fullStr | Amplitude Growth Functions of Auditory Nerve Responses to Electric
Pulse Stimulation With Varied Interphase Gaps in Cochlear Implant Users With
Ipsilateral Residual Hearing |
title_full_unstemmed | Amplitude Growth Functions of Auditory Nerve Responses to Electric
Pulse Stimulation With Varied Interphase Gaps in Cochlear Implant Users With
Ipsilateral Residual Hearing |
title_short | Amplitude Growth Functions of Auditory Nerve Responses to Electric
Pulse Stimulation With Varied Interphase Gaps in Cochlear Implant Users With
Ipsilateral Residual Hearing |
title_sort | amplitude growth functions of auditory nerve responses to electric
pulse stimulation with varied interphase gaps in cochlear implant users with
ipsilateral residual hearing |
topic | 2019 ISAAR special collection: Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243142/ https://www.ncbi.nlm.nih.gov/pubmed/34181493 http://dx.doi.org/10.1177/23312165211014137 |
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