Iron Chelator Transmetalative Approach to Inhibit Human Ribonucleotide Reductase

[Image: see text] Efforts directed at curtailing the bioavailability of intracellular iron could lead to the development of broad-spectrum anticancer drugs given the metal’s role in cancer proliferation and metastasis. Human ribonucleotide reductase (RNR), the key enzyme responsible for synthesizing...

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Detalles Bibliográficos
Autores principales: Gaur, Kavita, Pérez Otero, Sofia C., Benjamín-Rivera, Josué A., Rodríguez, Israel, Loza-Rosas, Sergio A., Vázquez Salgado, Alexandra M., Akam, Eman A., Hernández-Matias, Liz, Sharma, Rohit K., Alicea, Nahiara, Kowaleff, Martin, Washington, Anthony V., Astashkin, Andrei V., Tomat, Elisa, Tinoco, Arthur D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243325/
https://www.ncbi.nlm.nih.gov/pubmed/34240081
http://dx.doi.org/10.1021/jacsau.1c00078

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