Cargando…

A diagnostic miRNA signature for pulmonary arterial hypertension using a consensus machine learning approach

BACKGROUND: Pulmonary arterial hypertension (PAH) is a rare but life shortening disease, the diagnosis of which is often delayed, and requires an invasive right heart catheterisation. Identifying diagnostic biomarkers may improve screening to identify patients at risk of PAH earlier and provide new...

Descripción completa

Detalles Bibliográficos
Autores principales:	Errington, Niamh, Iremonger, James, Pickworth, Josephine A., Kariotis, Sokratis, Rhodes, Christopher J., Rothman, Alexander MK, Condliffe, Robin, Elliot, Charles A., Kiely, David G., Howard, Luke S., Wharton, John, Thompson, A. A. Roger, Morrell, Nicholas W, Wilkins, Martin R., Wang, Dennis, Lawrie, Allan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243351/ https://www.ncbi.nlm.nih.gov/pubmed/34186489 http://dx.doi.org/10.1016/j.ebiom.2021.103444

Ejemplares similares

Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood
por: Kariotis, Sokratis, et al.
Publicado: (2021)

Author Correction: Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood
por: Kariotis, Sokratis, et al.
Publicado: (2022)

Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling
por: Pickworth, Josephine, et al.
Publicado: (2017)

Whole-Blood RNA Profiles Associated with Pulmonary Arterial Hypertension and Clinical Outcome
por: Rhodes, Christopher J., et al.
Publicado: (2020)

Pulmonary Artery Denervation Reduces Pulmonary Artery Pressure and Induces Histological Changes in an Acute Porcine Model of Pulmonary Hypertension
por: Rothman, Alexander M.K., et al.
Publicado: (2015)

Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension
por: Condliffe, Robin, et al.
Publicado: (2012)

Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study
por: Rhodes, Christopher J, et al.
Publicado: (2017)

Altered Macrophage Polarization Induces Experimental Pulmonary Hypertension and Is Observed in Patients With Pulmonary Arterial Hypertension
por: Zawia, Amira, et al.
Publicado: (2020)

Soluble P-Selectin and von Willebrand Factor Rise in Healthy Volunteers Following Non-exertional Ascent to High Altitude
por: Turton, Helena A., et al.
Publicado: (2022)

Supplementation of iron in pulmonary hypertension: Rationale and design of a phase II clinical trial in idiopathic pulmonary arterial hypertension
por: Howard, Luke S.G.E., et al.
Publicado: (2013)

Deprivation and prognosis in patients with pulmonary arterial hypertension: missing the effect of deprivation on a rare disease?
por: Sofianopoulou, Eleni, et al.
Publicado: (2020)

Inhibition of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension
por: Hameed, Abdul G., et al.
Publicado: (2012)

A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension
por: Arnold, Nadine D., et al.
Publicado: (2019)

Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension
por: Boehm, Mario, et al.
Publicado: (2018)

Correction to: Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension
por: Boehm, Mario, et al.
Publicado: (2022)

Expression Quantitative Trait Locus Mapping in Pulmonary Arterial Hypertension
por: Ulrich, Anna, et al.
Publicado: (2020)

Right Ventricular Adaptation Assessed Using Cardiac Magnetic Resonance Predicts Survival in Pulmonary Arterial Hypertension
por: Goh, Ze Ming, et al.
Publicado: (2021)

Severe pulmonary hypertension associated with lung disease is characterised by a loss of small pulmonary vessels on quantitative computed tomography
por: Alkhanfar, Dheyaa, et al.
Publicado: (2022)

Editorial: Pulmonary Hypertension: Mechanisms and Management, History and Future
por: Thompson, A. A. Roger, et al.
Publicado: (2020)

Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension
por: Rhodes, Christopher J., et al.
Publicado: (2017)

Repeatability and sensitivity to change of non-invasive end points in PAH: the RESPIRE study
por: Swift, Andrew J, et al.
Publicado: (2021)

Circulating Protein Biomarkers in Systemic Sclerosis Related Pulmonary Arterial Hypertension: A Review of Published Data
por: Hickey, Peter M., et al.
Publicado: (2018)

Positioning imatinib for pulmonary arterial hypertension: A phase I/II design comprising dose finding and single-arm efficacy
por: Wilkins, Martin R., et al.
Publicado: (2021)

Incremental Shuttle Walking Test Distance Is Reduced in Patients With Pulmonary Hypertension in World Health Organisation Functional Class I
por: Billings, Catherine G., et al.
Publicado: (2018)

The incremental shuttle walk test predicts mortality in non-group 1 pulmonary hypertension: results from the ASPIRE Registry
por: Billings, Catherine G., et al.
Publicado: (2019)

Elevated Plasma CXCL12α Is Associated with a Poorer Prognosis in Pulmonary Arterial Hypertension
por: McCullagh, Brian N., et al.
Publicado: (2015)

Computational platform for doctor–artificial intelligence cooperation in pulmonary arterial hypertension prognostication: a pilot study
por: Kheyfets, Vitaly O., et al.
Publicado: (2023)

Screening strategies for pulmonary arterial hypertension
por: Kiely, David G, et al.
Publicado: (2019)

Connective tissue disease-associated pulmonary arterial hypertension
por: Condliffe, Robin, et al.
Publicado: (2015)

Selective improvement of pulmonary arterial hypertension with a dual ET(A)/ET(B) receptors antagonist in the apolipoprotein E(−/−) model of PAH and atherosclerosis
por: Renshall, Lewis, et al.
Publicado: (2017)

Plasma metabolomics exhibit response to therapy in chronic thromboembolic pulmonary hypertension
por: Swietlik, Emilia M., et al.
Publicado: (2021)

Diagnostic accuracy of CT pulmonary angiography in suspected pulmonary hypertension
por: Swift, Andrew J., et al.
Publicado: (2020)

Maximal Exercise Testing Using the Incremental Shuttle Walking Test Can Be Used to Risk-Stratify Patients with Pulmonary Arterial Hypertension
por: Lewis, Robert A., et al.
Publicado: (2021)

Supplementation with Iron in Pulmonary Arterial Hypertension. Two Randomized Crossover Trials
por: Howard, Luke S. G. E., et al.
Publicado: (2021)

Imaging and Risk Stratification in Pulmonary Arterial Hypertension: Time to Include Right Ventricular Assessment
por: Alandejani, Faisal, et al.
Publicado: (2022)

BNP/NT-proBNP in pulmonary arterial hypertension: time for point-of-care testing?
por: Lewis, Robert A., et al.
Publicado: (2020)

Extensive colonic pneumatosis in a patient on adjuvant chemotherapy after right colectomy for primary terminal ileum lymphoma: A decision-making process between surgical and non-surgical management
por: Kirmanidis, M., et al.
Publicado: (2018)

Right ventricular remodelling in pulmonary arterial hypertension predicts treatment response
por: Goh, Ze Ming, et al.
Publicado: (2022)

The Pathway Coexpression Network: Revealing pathway relationships
por: Pita-Juárez, Yered, et al.
Publicado: (2018)

Non-invasive methods for estimating mPAP in COPD using cardiovascular magnetic resonance imaging
por: Johns, C. S., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_gpplbh334f0logktk4ankls9ib