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Prevalence and determinants of diabetes and prediabetes in southwestern Iran: the Khuzestan comprehensive health study (KCHS)

BACKGROUND: The Middle East and North Africa (MENA) is postulated to have the highest increase in the prevalence of diabetes by 2030; however, studies on the epidemiology of diabetes are rather limited across the region, including in Iran. METHODS: This study was conducted between 2016 and 2018 amon...

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Autores principales: Hariri, Sanam, Rahimi, Zahra, Hashemi-Madani, Nahid, Mard, Seyyed Ali, Hashemi, Farnaz, Mohammadi, Zahra, Danehchin, Leila, Abolnezhadian, Farhad, Valipour, Aliasghar, Paridar, Yousef, Mir-Nasseri, Mohammad Mahdi, Khajavi, Alireza, Masoudi, Sahar, Alvand, Saba, Cheraghian, Bahman, Shayesteh, Ali Akbar, Khamseh, Mohammad E., Poustchi, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243419/
https://www.ncbi.nlm.nih.gov/pubmed/34187451
http://dx.doi.org/10.1186/s12902-021-00790-x
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author Hariri, Sanam
Rahimi, Zahra
Hashemi-Madani, Nahid
Mard, Seyyed Ali
Hashemi, Farnaz
Mohammadi, Zahra
Danehchin, Leila
Abolnezhadian, Farhad
Valipour, Aliasghar
Paridar, Yousef
Mir-Nasseri, Mohammad Mahdi
Khajavi, Alireza
Masoudi, Sahar
Alvand, Saba
Cheraghian, Bahman
Shayesteh, Ali Akbar
Khamseh, Mohammad E.
Poustchi, Hossein
author_facet Hariri, Sanam
Rahimi, Zahra
Hashemi-Madani, Nahid
Mard, Seyyed Ali
Hashemi, Farnaz
Mohammadi, Zahra
Danehchin, Leila
Abolnezhadian, Farhad
Valipour, Aliasghar
Paridar, Yousef
Mir-Nasseri, Mohammad Mahdi
Khajavi, Alireza
Masoudi, Sahar
Alvand, Saba
Cheraghian, Bahman
Shayesteh, Ali Akbar
Khamseh, Mohammad E.
Poustchi, Hossein
author_sort Hariri, Sanam
collection PubMed
description BACKGROUND: The Middle East and North Africa (MENA) is postulated to have the highest increase in the prevalence of diabetes by 2030; however, studies on the epidemiology of diabetes are rather limited across the region, including in Iran. METHODS: This study was conducted between 2016 and 2018 among Iranian adults aged 20 to 65 years residing in Khuzestan province, southwestern Iran. Diabetes was defined as the fasting blood glucose (FBG) level of 126 mg/dl or higher, and/or taking antidiabetic medications, and/or self-declared diabetes. Prediabetes was defined as FBG 100 to 125 mg/dl. Multinomial logistic regression models were used to examine the association of multiple risk factors that attained significance on the outcome. RESULTS: Overall, 30,498 participants were recruited; the mean (±SD) age was 41.6 (±11.9) years. The prevalence of prediabetes and diabetes were 30.8 and 15.3%, respectively. We found a similar prevalence of diabetes in both sexes, although it was higher among illiterates, urban residents, married people, and smokers. Participants aged 50–65 and those with Body Mass Index (BMI) 30 kg/m(2) or higher were more likely to be affected by diabetes [RR: 20.5 (18.1,23.3) and 3.2 (3.0,3.6)]. Hypertension [RR: 5.1 (4.7,5.5)], waist circumference (WC) equal or more than 90 cm [RR: 3.6 (3.3,3.9)], and family history [RR: 2.3 (2.2,2.5)] were also significantly associated with diabetes. For prediabetes, the main risk factors were age 50 to 65 years [RR: 2.6 (2.4,2.8)], BMI 30 kg/m(2) or higher [RR: 1.9 (1.8,2.0)], hypertension and WC of 90 cm or higher [RR: 1.7 (1.6,1.8)]. The adjusted relative risks for all variables were higher in females than males, with the exception of family history for both conditions and waist circumference for prediabetes. CONCLUSIONS: Prediabetes and diabetes are prevalent in southwestern Iran. The major determinants are older age, obesity, and the presence of hypertension. Further interventions are required to escalate diabetes prevention and diagnosis in high-risk areas across Iran. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12902-021-00790-x.
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spelling pubmed-82434192021-06-30 Prevalence and determinants of diabetes and prediabetes in southwestern Iran: the Khuzestan comprehensive health study (KCHS) Hariri, Sanam Rahimi, Zahra Hashemi-Madani, Nahid Mard, Seyyed Ali Hashemi, Farnaz Mohammadi, Zahra Danehchin, Leila Abolnezhadian, Farhad Valipour, Aliasghar Paridar, Yousef Mir-Nasseri, Mohammad Mahdi Khajavi, Alireza Masoudi, Sahar Alvand, Saba Cheraghian, Bahman Shayesteh, Ali Akbar Khamseh, Mohammad E. Poustchi, Hossein BMC Endocr Disord Research BACKGROUND: The Middle East and North Africa (MENA) is postulated to have the highest increase in the prevalence of diabetes by 2030; however, studies on the epidemiology of diabetes are rather limited across the region, including in Iran. METHODS: This study was conducted between 2016 and 2018 among Iranian adults aged 20 to 65 years residing in Khuzestan province, southwestern Iran. Diabetes was defined as the fasting blood glucose (FBG) level of 126 mg/dl or higher, and/or taking antidiabetic medications, and/or self-declared diabetes. Prediabetes was defined as FBG 100 to 125 mg/dl. Multinomial logistic regression models were used to examine the association of multiple risk factors that attained significance on the outcome. RESULTS: Overall, 30,498 participants were recruited; the mean (±SD) age was 41.6 (±11.9) years. The prevalence of prediabetes and diabetes were 30.8 and 15.3%, respectively. We found a similar prevalence of diabetes in both sexes, although it was higher among illiterates, urban residents, married people, and smokers. Participants aged 50–65 and those with Body Mass Index (BMI) 30 kg/m(2) or higher were more likely to be affected by diabetes [RR: 20.5 (18.1,23.3) and 3.2 (3.0,3.6)]. Hypertension [RR: 5.1 (4.7,5.5)], waist circumference (WC) equal or more than 90 cm [RR: 3.6 (3.3,3.9)], and family history [RR: 2.3 (2.2,2.5)] were also significantly associated with diabetes. For prediabetes, the main risk factors were age 50 to 65 years [RR: 2.6 (2.4,2.8)], BMI 30 kg/m(2) or higher [RR: 1.9 (1.8,2.0)], hypertension and WC of 90 cm or higher [RR: 1.7 (1.6,1.8)]. The adjusted relative risks for all variables were higher in females than males, with the exception of family history for both conditions and waist circumference for prediabetes. CONCLUSIONS: Prediabetes and diabetes are prevalent in southwestern Iran. The major determinants are older age, obesity, and the presence of hypertension. Further interventions are required to escalate diabetes prevention and diagnosis in high-risk areas across Iran. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12902-021-00790-x. BioMed Central 2021-06-29 /pmc/articles/PMC8243419/ /pubmed/34187451 http://dx.doi.org/10.1186/s12902-021-00790-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Hariri, Sanam
Rahimi, Zahra
Hashemi-Madani, Nahid
Mard, Seyyed Ali
Hashemi, Farnaz
Mohammadi, Zahra
Danehchin, Leila
Abolnezhadian, Farhad
Valipour, Aliasghar
Paridar, Yousef
Mir-Nasseri, Mohammad Mahdi
Khajavi, Alireza
Masoudi, Sahar
Alvand, Saba
Cheraghian, Bahman
Shayesteh, Ali Akbar
Khamseh, Mohammad E.
Poustchi, Hossein
Prevalence and determinants of diabetes and prediabetes in southwestern Iran: the Khuzestan comprehensive health study (KCHS)
title Prevalence and determinants of diabetes and prediabetes in southwestern Iran: the Khuzestan comprehensive health study (KCHS)
title_full Prevalence and determinants of diabetes and prediabetes in southwestern Iran: the Khuzestan comprehensive health study (KCHS)
title_fullStr Prevalence and determinants of diabetes and prediabetes in southwestern Iran: the Khuzestan comprehensive health study (KCHS)
title_full_unstemmed Prevalence and determinants of diabetes and prediabetes in southwestern Iran: the Khuzestan comprehensive health study (KCHS)
title_short Prevalence and determinants of diabetes and prediabetes in southwestern Iran: the Khuzestan comprehensive health study (KCHS)
title_sort prevalence and determinants of diabetes and prediabetes in southwestern iran: the khuzestan comprehensive health study (kchs)
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243419/
https://www.ncbi.nlm.nih.gov/pubmed/34187451
http://dx.doi.org/10.1186/s12902-021-00790-x
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