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Determinants of macular ganglion cell–inner plexiform layer thickness in normal Chinese adults

BACKGROUND: Demographic, systemic and ocular factors may impact macular ganglion cell–inner plexiform layer (GCIPL) thickness measurements. This study aimed to investigate the influences of multiple potential determinants of macular GCIPL thickness in normal Chinese adults. METHODS: This was a retro...

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Autores principales: Xu, Xiaoyu, Xiao, Hui, Lai, Kunbei, Guo, Xinxing, Luo, Jingyi, Liu, Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243422/
https://www.ncbi.nlm.nih.gov/pubmed/34187398
http://dx.doi.org/10.1186/s12886-021-02023-0
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author Xu, Xiaoyu
Xiao, Hui
Lai, Kunbei
Guo, Xinxing
Luo, Jingyi
Liu, Xing
author_facet Xu, Xiaoyu
Xiao, Hui
Lai, Kunbei
Guo, Xinxing
Luo, Jingyi
Liu, Xing
author_sort Xu, Xiaoyu
collection PubMed
description BACKGROUND: Demographic, systemic and ocular factors may impact macular ganglion cell–inner plexiform layer (GCIPL) thickness measurements. This study aimed to investigate the influences of multiple potential determinants of macular GCIPL thickness in normal Chinese adults. METHODS: This was a retrospective study conducted on 225 normal eyes from 225 healthy Chinese adults. GCIPL thickness were obtained using Cirrus high-definition optical coherence tomography (OCT). The age, gender, laterality, spherical equivalent (SE) refractive error, intraocular pressure (IOP), axial length (AL), central cornea thickness (CCT), circumpapillary retinal nerve fibre layer (pRNFL) thickness and OCT signal strength were recorded and their respective effect on GCIPL thickness parameters were evaluated. RESULTS: The mean (± SD) average, minimum, superotemporal, superior, superonasal, inferonasal, inferior, and inferotemporal GCIPL thickness was 84.56 ± 5.36, 81.32 ± 5.58, 83.08 ± 5.37, 85.70 ± 5.95, 87.15 ± 6.26, 85.07 ± 6.11, 82.46 ± 5.76, and 83.88 ± 5.59 μm, respectively. Determinants of thinner GCIPL thickness were older age (P = 0.001–0.117; effects enhanced if age over 40 years), thinner pRNFL (all P < 0.001), and weaker signal strength (all P < 0.001). No significant difference was found between males and females (P = 0.069–0.842), and between right eyes and the left eyes (P = 0.160–0.875) except that of superonasal GCIPL thickness (P < 0.001). There was no significant correlation between GCIPL thickness and SE, IOP, CCT, and AL (P = 0.135–0.968). CONCLUSIONS: Individual determinants associated with thinner GCIPL thickness were older age (particularly over 40 years of age), thinner pRNFL, and weaker OCT signal strength. This is relevant in comprehensively understanding the normative data and differentiating normal aging from abnormalities.
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spelling pubmed-82434222021-06-30 Determinants of macular ganglion cell–inner plexiform layer thickness in normal Chinese adults Xu, Xiaoyu Xiao, Hui Lai, Kunbei Guo, Xinxing Luo, Jingyi Liu, Xing BMC Ophthalmol Research Article BACKGROUND: Demographic, systemic and ocular factors may impact macular ganglion cell–inner plexiform layer (GCIPL) thickness measurements. This study aimed to investigate the influences of multiple potential determinants of macular GCIPL thickness in normal Chinese adults. METHODS: This was a retrospective study conducted on 225 normal eyes from 225 healthy Chinese adults. GCIPL thickness were obtained using Cirrus high-definition optical coherence tomography (OCT). The age, gender, laterality, spherical equivalent (SE) refractive error, intraocular pressure (IOP), axial length (AL), central cornea thickness (CCT), circumpapillary retinal nerve fibre layer (pRNFL) thickness and OCT signal strength were recorded and their respective effect on GCIPL thickness parameters were evaluated. RESULTS: The mean (± SD) average, minimum, superotemporal, superior, superonasal, inferonasal, inferior, and inferotemporal GCIPL thickness was 84.56 ± 5.36, 81.32 ± 5.58, 83.08 ± 5.37, 85.70 ± 5.95, 87.15 ± 6.26, 85.07 ± 6.11, 82.46 ± 5.76, and 83.88 ± 5.59 μm, respectively. Determinants of thinner GCIPL thickness were older age (P = 0.001–0.117; effects enhanced if age over 40 years), thinner pRNFL (all P < 0.001), and weaker signal strength (all P < 0.001). No significant difference was found between males and females (P = 0.069–0.842), and between right eyes and the left eyes (P = 0.160–0.875) except that of superonasal GCIPL thickness (P < 0.001). There was no significant correlation between GCIPL thickness and SE, IOP, CCT, and AL (P = 0.135–0.968). CONCLUSIONS: Individual determinants associated with thinner GCIPL thickness were older age (particularly over 40 years of age), thinner pRNFL, and weaker OCT signal strength. This is relevant in comprehensively understanding the normative data and differentiating normal aging from abnormalities. BioMed Central 2021-06-29 /pmc/articles/PMC8243422/ /pubmed/34187398 http://dx.doi.org/10.1186/s12886-021-02023-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Xu, Xiaoyu
Xiao, Hui
Lai, Kunbei
Guo, Xinxing
Luo, Jingyi
Liu, Xing
Determinants of macular ganglion cell–inner plexiform layer thickness in normal Chinese adults
title Determinants of macular ganglion cell–inner plexiform layer thickness in normal Chinese adults
title_full Determinants of macular ganglion cell–inner plexiform layer thickness in normal Chinese adults
title_fullStr Determinants of macular ganglion cell–inner plexiform layer thickness in normal Chinese adults
title_full_unstemmed Determinants of macular ganglion cell–inner plexiform layer thickness in normal Chinese adults
title_short Determinants of macular ganglion cell–inner plexiform layer thickness in normal Chinese adults
title_sort determinants of macular ganglion cell–inner plexiform layer thickness in normal chinese adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243422/
https://www.ncbi.nlm.nih.gov/pubmed/34187398
http://dx.doi.org/10.1186/s12886-021-02023-0
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