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MicroRNAs: emerging driver of cancer perineural invasion

The perineural invasion (PNI), which refers to tumor cells encroaching on nerve, is a clinical feature frequently occurred in various malignant tumors, and responsible for postoperative recurrence, metastasis and decreased survival. The pathogenesis of PNI switches from ‘low-resistance channel’ hypo...

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Autores principales: Zhang, Mei, Xian, Hong-chun, Dai, Li, Tang, Ya-ling, Liang, Xin-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243427/
https://www.ncbi.nlm.nih.gov/pubmed/34187567
http://dx.doi.org/10.1186/s13578-021-00630-4
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author Zhang, Mei
Xian, Hong-chun
Dai, Li
Tang, Ya-ling
Liang, Xin-hua
author_facet Zhang, Mei
Xian, Hong-chun
Dai, Li
Tang, Ya-ling
Liang, Xin-hua
author_sort Zhang, Mei
collection PubMed
description The perineural invasion (PNI), which refers to tumor cells encroaching on nerve, is a clinical feature frequently occurred in various malignant tumors, and responsible for postoperative recurrence, metastasis and decreased survival. The pathogenesis of PNI switches from ‘low-resistance channel’ hypothesis to ‘mutual attraction’ theory between peripheral nerves and tumor cells in perineural niche. Among various molecules in perineural niche, microRNA (miRNA) as an emerging modulator of PNI through generating RNA-induced silencing complex (RISC) to orchestrate oncogene and anti-oncogene has aroused a wide attention. This article systematically reviewed the role of microRNA in PNI, promising to identify new biomarkers and offer cancer therapeutic targets.
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spelling pubmed-82434272021-06-30 MicroRNAs: emerging driver of cancer perineural invasion Zhang, Mei Xian, Hong-chun Dai, Li Tang, Ya-ling Liang, Xin-hua Cell Biosci Review The perineural invasion (PNI), which refers to tumor cells encroaching on nerve, is a clinical feature frequently occurred in various malignant tumors, and responsible for postoperative recurrence, metastasis and decreased survival. The pathogenesis of PNI switches from ‘low-resistance channel’ hypothesis to ‘mutual attraction’ theory between peripheral nerves and tumor cells in perineural niche. Among various molecules in perineural niche, microRNA (miRNA) as an emerging modulator of PNI through generating RNA-induced silencing complex (RISC) to orchestrate oncogene and anti-oncogene has aroused a wide attention. This article systematically reviewed the role of microRNA in PNI, promising to identify new biomarkers and offer cancer therapeutic targets. BioMed Central 2021-06-29 /pmc/articles/PMC8243427/ /pubmed/34187567 http://dx.doi.org/10.1186/s13578-021-00630-4 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zhang, Mei
Xian, Hong-chun
Dai, Li
Tang, Ya-ling
Liang, Xin-hua
MicroRNAs: emerging driver of cancer perineural invasion
title MicroRNAs: emerging driver of cancer perineural invasion
title_full MicroRNAs: emerging driver of cancer perineural invasion
title_fullStr MicroRNAs: emerging driver of cancer perineural invasion
title_full_unstemmed MicroRNAs: emerging driver of cancer perineural invasion
title_short MicroRNAs: emerging driver of cancer perineural invasion
title_sort micrornas: emerging driver of cancer perineural invasion
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243427/
https://www.ncbi.nlm.nih.gov/pubmed/34187567
http://dx.doi.org/10.1186/s13578-021-00630-4
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