The dysregulated expression and functional effect of CaMK2 in cancer

CaMK2 (calcium/calmodulin-dependent protein kinase 2), a multifunctional serine/threonine-protein kinase involved in diverse cellular processes, is vital for the transduction of the Ca(2+) signaling cascade. Recently, research has highlighted the involvement of CaMK2 in cancer development. However,...

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Detalles Bibliográficos
Autores principales: He, Qi, Li, Zhenyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243487/
https://www.ncbi.nlm.nih.gov/pubmed/34193145
http://dx.doi.org/10.1186/s12935-021-02030-7
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author He, Qi
Li, Zhenyu
author_facet He, Qi
Li, Zhenyu
author_sort He, Qi
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description CaMK2 (calcium/calmodulin-dependent protein kinase 2), a multifunctional serine/threonine-protein kinase involved in diverse cellular processes, is vital for the transduction of the Ca(2+) signaling cascade. Recently, research has highlighted the involvement of CaMK2 in cancer development. However, the specific effects of CaMK2 on cancer have not been fully elucidated. In this review, we summarize not only the altered expression of CaMK2 in a range of cancers, as evidenced by bioinformatics analysis, but also the significant role of CaMK2 in regulating cancer progression, such as proliferation and metastasis. In addition, we described the functional influence of CaMK2 on cancer stemness and resistance. Understanding the critical effects and mechanisms of CaMK2 in cancer would facilitate the development of a promising therapeutic strategy for cancer treatment.
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spelling pubmed-82434872021-06-30 The dysregulated expression and functional effect of CaMK2 in cancer He, Qi Li, Zhenyu Cancer Cell Int Review CaMK2 (calcium/calmodulin-dependent protein kinase 2), a multifunctional serine/threonine-protein kinase involved in diverse cellular processes, is vital for the transduction of the Ca(2+) signaling cascade. Recently, research has highlighted the involvement of CaMK2 in cancer development. However, the specific effects of CaMK2 on cancer have not been fully elucidated. In this review, we summarize not only the altered expression of CaMK2 in a range of cancers, as evidenced by bioinformatics analysis, but also the significant role of CaMK2 in regulating cancer progression, such as proliferation and metastasis. In addition, we described the functional influence of CaMK2 on cancer stemness and resistance. Understanding the critical effects and mechanisms of CaMK2 in cancer would facilitate the development of a promising therapeutic strategy for cancer treatment. BioMed Central 2021-06-30 /pmc/articles/PMC8243487/ /pubmed/34193145 http://dx.doi.org/10.1186/s12935-021-02030-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
He, Qi
Li, Zhenyu
The dysregulated expression and functional effect of CaMK2 in cancer
title The dysregulated expression and functional effect of CaMK2 in cancer
title_full The dysregulated expression and functional effect of CaMK2 in cancer
title_fullStr The dysregulated expression and functional effect of CaMK2 in cancer
title_full_unstemmed The dysregulated expression and functional effect of CaMK2 in cancer
title_short The dysregulated expression and functional effect of CaMK2 in cancer
title_sort dysregulated expression and functional effect of camk2 in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243487/
https://www.ncbi.nlm.nih.gov/pubmed/34193145
http://dx.doi.org/10.1186/s12935-021-02030-7
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