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Characteristics of diffusion-weighted and blood oxygen level-dependent magnetic resonance imaging in Tubulointerstitial nephritis: an initial experience
BACKGROUND: Diffusion-weighted (DW) and blood oxygen level-dependent (BOLD) magnetic resonance imaging are classical sequences of functional MR, but the exploration in non-transplanted kidney disease is limited. Objects: To analyze the characteristics of apparent diffusion coefficient (ADC) and R(2)...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243503/ https://www.ncbi.nlm.nih.gov/pubmed/34187388 http://dx.doi.org/10.1186/s12882-021-02435-6 |
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author | Su, Tao Yang, Xuedong Wang, Rui Yang, Li Wang, Xiaoying |
author_facet | Su, Tao Yang, Xuedong Wang, Rui Yang, Li Wang, Xiaoying |
author_sort | Su, Tao |
collection | PubMed |
description | BACKGROUND: Diffusion-weighted (DW) and blood oxygen level-dependent (BOLD) magnetic resonance imaging are classical sequences of functional MR, but the exploration in non-transplanted kidney disease is limited. Objects: To analyze the characteristics of apparent diffusion coefficient (ADC) and R(2)* value using DW and BOLD imaging in tubulointerstitial nephritis (TIN). METHODS: Four acute TIN, thirteen chronic TIN patients, and four controls were enrolled. We used multiple gradient-echo sequences to acquire 12 T2*-weighted images to calculate the R(2)* map. DW imaging acquired ADC values by combining a single-shot spin-echo echo-planar imaging pulse sequence and the additional motion probing gradient pulses along the x,y, z-axes with two b values:0 and 200, as well as 0 and 800 s/mm(2). ATIN patients performed DW and BOLD magnetic resonance at renal biopsy(T(0)) and the third month(T(3)). We assessed the pathological changes semiquantitatively, and conducted correlation analyses within functional MR, pathological and clinical indexes. RESULTS: In ATIN, ADCs were significantly lower(b was 0,200 s/mm(2), 2.86 ± 0.19 vs. 3.39 ± 0.11, b was 0,800 s/mm(2), 1.76 ± 0.12 vs. 2.16 ± 0.08, P < 0.05) than controls, showing an obvious remission at T(3). Cortical and medullary R(2)* values (CR(2)*,MR(2)*) were decreased, significant difference was only observed in MR(2)*(T(0) 24.3 ± 2.1vs.T(3) 33.1 ± 4.1,P < 0.05). No relationship was found between functional MR and histopathological indexes.MR(2)* had a close relationship with eGFR (R = 0.682,P = 0.001) and serum creatinine(R = -0.502,P = 0.012). Patients with lower ADC when b was 0,200 s/mm(2) showed more increase of ADC(R = -0.956,P = 0.044) and MR(2)*(R = -0.949,P = 0.05) after therapy. In CTIN group, lowered MR(2)* and MR(2)*/CR(2)* provided evidence of intrarenal ischemia. CTIN with advanced CKD (eGFR< 45) had significantly lower ADC(b200) value. CONCLUSIONS: We observed the reduction and remission of ADC and R(2)* values in ATIN case series. ATIN patients had concurrently decreased ADC(b800) and MR(2)*. The pseudo normalization of CR(2)* with persistently low MR(2)* in CTIN suggested intrarenal hypoxia. |
format | Online Article Text |
id | pubmed-8243503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82435032021-06-30 Characteristics of diffusion-weighted and blood oxygen level-dependent magnetic resonance imaging in Tubulointerstitial nephritis: an initial experience Su, Tao Yang, Xuedong Wang, Rui Yang, Li Wang, Xiaoying BMC Nephrol Research Article BACKGROUND: Diffusion-weighted (DW) and blood oxygen level-dependent (BOLD) magnetic resonance imaging are classical sequences of functional MR, but the exploration in non-transplanted kidney disease is limited. Objects: To analyze the characteristics of apparent diffusion coefficient (ADC) and R(2)* value using DW and BOLD imaging in tubulointerstitial nephritis (TIN). METHODS: Four acute TIN, thirteen chronic TIN patients, and four controls were enrolled. We used multiple gradient-echo sequences to acquire 12 T2*-weighted images to calculate the R(2)* map. DW imaging acquired ADC values by combining a single-shot spin-echo echo-planar imaging pulse sequence and the additional motion probing gradient pulses along the x,y, z-axes with two b values:0 and 200, as well as 0 and 800 s/mm(2). ATIN patients performed DW and BOLD magnetic resonance at renal biopsy(T(0)) and the third month(T(3)). We assessed the pathological changes semiquantitatively, and conducted correlation analyses within functional MR, pathological and clinical indexes. RESULTS: In ATIN, ADCs were significantly lower(b was 0,200 s/mm(2), 2.86 ± 0.19 vs. 3.39 ± 0.11, b was 0,800 s/mm(2), 1.76 ± 0.12 vs. 2.16 ± 0.08, P < 0.05) than controls, showing an obvious remission at T(3). Cortical and medullary R(2)* values (CR(2)*,MR(2)*) were decreased, significant difference was only observed in MR(2)*(T(0) 24.3 ± 2.1vs.T(3) 33.1 ± 4.1,P < 0.05). No relationship was found between functional MR and histopathological indexes.MR(2)* had a close relationship with eGFR (R = 0.682,P = 0.001) and serum creatinine(R = -0.502,P = 0.012). Patients with lower ADC when b was 0,200 s/mm(2) showed more increase of ADC(R = -0.956,P = 0.044) and MR(2)*(R = -0.949,P = 0.05) after therapy. In CTIN group, lowered MR(2)* and MR(2)*/CR(2)* provided evidence of intrarenal ischemia. CTIN with advanced CKD (eGFR< 45) had significantly lower ADC(b200) value. CONCLUSIONS: We observed the reduction and remission of ADC and R(2)* values in ATIN case series. ATIN patients had concurrently decreased ADC(b800) and MR(2)*. The pseudo normalization of CR(2)* with persistently low MR(2)* in CTIN suggested intrarenal hypoxia. BioMed Central 2021-06-29 /pmc/articles/PMC8243503/ /pubmed/34187388 http://dx.doi.org/10.1186/s12882-021-02435-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Su, Tao Yang, Xuedong Wang, Rui Yang, Li Wang, Xiaoying Characteristics of diffusion-weighted and blood oxygen level-dependent magnetic resonance imaging in Tubulointerstitial nephritis: an initial experience |
title | Characteristics of diffusion-weighted and blood oxygen level-dependent magnetic resonance imaging in Tubulointerstitial nephritis: an initial experience |
title_full | Characteristics of diffusion-weighted and blood oxygen level-dependent magnetic resonance imaging in Tubulointerstitial nephritis: an initial experience |
title_fullStr | Characteristics of diffusion-weighted and blood oxygen level-dependent magnetic resonance imaging in Tubulointerstitial nephritis: an initial experience |
title_full_unstemmed | Characteristics of diffusion-weighted and blood oxygen level-dependent magnetic resonance imaging in Tubulointerstitial nephritis: an initial experience |
title_short | Characteristics of diffusion-weighted and blood oxygen level-dependent magnetic resonance imaging in Tubulointerstitial nephritis: an initial experience |
title_sort | characteristics of diffusion-weighted and blood oxygen level-dependent magnetic resonance imaging in tubulointerstitial nephritis: an initial experience |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243503/ https://www.ncbi.nlm.nih.gov/pubmed/34187388 http://dx.doi.org/10.1186/s12882-021-02435-6 |
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