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Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats

BACKGROUND: Parquetina nigrescens is among the evergreen plants native to West Africa. It is used in the management of various ailments including anemia, fever, asthma and diabetes. This study evaluated the antidiabetic and antihyperlipidemic effect of Parquetina nigrescens in streptozotocin–nicotin...

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Autores principales: Ojuade, Fatimoh Idowu, Olorundare, Olufunke Esan, Akanbi, Olatunde Babatunde, Afolabi, Saheed Olanrewaju, Njan, Anoka Ayembe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243517/
https://www.ncbi.nlm.nih.gov/pubmed/34222697
http://dx.doi.org/10.1016/j.heliyon.2021.e07363
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author Ojuade, Fatimoh Idowu
Olorundare, Olufunke Esan
Akanbi, Olatunde Babatunde
Afolabi, Saheed Olanrewaju
Njan, Anoka Ayembe
author_facet Ojuade, Fatimoh Idowu
Olorundare, Olufunke Esan
Akanbi, Olatunde Babatunde
Afolabi, Saheed Olanrewaju
Njan, Anoka Ayembe
author_sort Ojuade, Fatimoh Idowu
collection PubMed
description BACKGROUND: Parquetina nigrescens is among the evergreen plants native to West Africa. It is used in the management of various ailments including anemia, fever, asthma and diabetes. This study evaluated the antidiabetic and antihyperlipidemic effect of Parquetina nigrescens in streptozotocin–nicotinamide-induced type 2 diabetic rats. METHODS: Type 2 diabetes mellitus was induced in overnight fasted rats with a single intraperitoneal injection of streptozotocin (60 mg/kg), followed by the administration of nicotinamide (120 mg/kg) after an interval of 15 min. Diabetic rats were orally administered with; 200, 400 and 800 mg/kg of aqueous extract of Parquetina nigrescens (AEPN), metformin (180 mg/kg) and glibenclamide (1 mg/kg) for two weeks. The effect of treatments on fasting blood glucose, serum insulin, leptin, adiponectin, homa-ir, lipid profile, body weight, pancreatic antioxidants parameters, hepatic glycogen content, glucose-6-phosphate activity, α-amylase inhibition, α-glucosidase inhibition, lipase inhibition and histology of the organs were evaluated. RESULTS: Data from this study showed that treatment with AEPN produced a significant reduction (p < 0.05) in fasting blood glucose, glucose-6-phosphatase activity, serum lipase, total triglyceride, total cholesterol, low-density lipoproteins, very low-density lipoprotein, atherogenic index, coronary risk index, pancreatic α-amylase, α-glucosidase and lipase activities. Treatment with AEPN also produced a significant (p < 0.05) increase in; glucose tolerance, glycogen content, leptin, adiponectin and pancreatic antioxidants (glutathione, superoxide dismutase, catalase and high-density lipoproteins). The histology of the organ showed regeneration of the pancreatic tissue after treatment with AEPN. CONCLUSIONS: This study showed that AEPN exhibited antidiabetic and antihyperlipidemic activity in streptozotocin–nicotinamide-induced type 2 diabetic rats.
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spelling pubmed-82435172021-07-02 Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats Ojuade, Fatimoh Idowu Olorundare, Olufunke Esan Akanbi, Olatunde Babatunde Afolabi, Saheed Olanrewaju Njan, Anoka Ayembe Heliyon Research Article BACKGROUND: Parquetina nigrescens is among the evergreen plants native to West Africa. It is used in the management of various ailments including anemia, fever, asthma and diabetes. This study evaluated the antidiabetic and antihyperlipidemic effect of Parquetina nigrescens in streptozotocin–nicotinamide-induced type 2 diabetic rats. METHODS: Type 2 diabetes mellitus was induced in overnight fasted rats with a single intraperitoneal injection of streptozotocin (60 mg/kg), followed by the administration of nicotinamide (120 mg/kg) after an interval of 15 min. Diabetic rats were orally administered with; 200, 400 and 800 mg/kg of aqueous extract of Parquetina nigrescens (AEPN), metformin (180 mg/kg) and glibenclamide (1 mg/kg) for two weeks. The effect of treatments on fasting blood glucose, serum insulin, leptin, adiponectin, homa-ir, lipid profile, body weight, pancreatic antioxidants parameters, hepatic glycogen content, glucose-6-phosphate activity, α-amylase inhibition, α-glucosidase inhibition, lipase inhibition and histology of the organs were evaluated. RESULTS: Data from this study showed that treatment with AEPN produced a significant reduction (p < 0.05) in fasting blood glucose, glucose-6-phosphatase activity, serum lipase, total triglyceride, total cholesterol, low-density lipoproteins, very low-density lipoprotein, atherogenic index, coronary risk index, pancreatic α-amylase, α-glucosidase and lipase activities. Treatment with AEPN also produced a significant (p < 0.05) increase in; glucose tolerance, glycogen content, leptin, adiponectin and pancreatic antioxidants (glutathione, superoxide dismutase, catalase and high-density lipoproteins). The histology of the organ showed regeneration of the pancreatic tissue after treatment with AEPN. CONCLUSIONS: This study showed that AEPN exhibited antidiabetic and antihyperlipidemic activity in streptozotocin–nicotinamide-induced type 2 diabetic rats. Elsevier 2021-06-21 /pmc/articles/PMC8243517/ /pubmed/34222697 http://dx.doi.org/10.1016/j.heliyon.2021.e07363 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Ojuade, Fatimoh Idowu
Olorundare, Olufunke Esan
Akanbi, Olatunde Babatunde
Afolabi, Saheed Olanrewaju
Njan, Anoka Ayembe
Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats
title Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats
title_full Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats
title_fullStr Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats
title_full_unstemmed Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats
title_short Antidiabetic and antihyperlipidemic effects of aqueous extract of Parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats
title_sort antidiabetic and antihyperlipidemic effects of aqueous extract of parquetina nigrescens in streptozotocin–nicotinamide induced type 2 diabetic rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243517/
https://www.ncbi.nlm.nih.gov/pubmed/34222697
http://dx.doi.org/10.1016/j.heliyon.2021.e07363
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