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Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study
BACKGROUND AND AIM: The prebiotics, mannan-oligosaccharides (MOS), demonstrate the ability to increase probiotic microorganisms and fixation and removal of pathogens associated with chronic systemic inflammation in the digestive system. Inflammatory processes play an important role in modulating the...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Veterinary World
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243662/ https://www.ncbi.nlm.nih.gov/pubmed/34220123 http://dx.doi.org/10.14202/vetworld.2021.1210-1219 |
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author | Rodrigues, Luiz Eduardo Kishibe, Milena Miyoshi Keller, Rogeria Caetano, Heliard Rodrigues dos Santos Rufino, Marcos Natal Sanches, Osimar de Carvalho Giometti, Ines Cristina Giuffrida, Rogério Bremer-Neto, Hermann |
author_facet | Rodrigues, Luiz Eduardo Kishibe, Milena Miyoshi Keller, Rogeria Caetano, Heliard Rodrigues dos Santos Rufino, Marcos Natal Sanches, Osimar de Carvalho Giometti, Ines Cristina Giuffrida, Rogério Bremer-Neto, Hermann |
author_sort | Rodrigues, Luiz Eduardo |
collection | PubMed |
description | BACKGROUND AND AIM: The prebiotics, mannan-oligosaccharides (MOS), demonstrate the ability to increase probiotic microorganisms and fixation and removal of pathogens associated with chronic systemic inflammation in the digestive system. Inflammatory processes play an important role in modulating the brain-intestinal axis, including maintaining male reproductive function and spermatogenesis and regulating stress. The aim of the present study was to evaluate the action of MOS on testosterone and corticosterone concentrations and the reproductive system development of rats in the growth phase as an animal model. MATERIALS AND METHODS: In total, 128 male rats were used, randomly divided into four experimental groups (n=32): Control; MOS 1; MOS 2; and MOS 3. From each group, eight animals were sacrificed in four experimental moments (14, 28, 42, and 56 days, respectively, moments 1, 2, 3, and 4) and hormonal measurements and histological evaluations were performed. RESULTS: The results revealed the effect of diet, MOS, and timing on testicle weight (p<0.05). At moments 3 and 4, the groups supplemented with MOS showed higher concentrations of testosterone and decreased corticosterone levels throughout the experimental period. Groups supplemented with MOS showed an increase in the frequency of relative sperm and sperm scores. The radii of the seminiferous tubules presented a significant statistical effect of the diet, moments, and diet + moment interaction. CONCLUSION: It was concluded that the three different MOS prebiotics brought forward sexual maturity. |
format | Online Article Text |
id | pubmed-8243662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Veterinary World |
record_format | MEDLINE/PubMed |
spelling | pubmed-82436622021-07-02 Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study Rodrigues, Luiz Eduardo Kishibe, Milena Miyoshi Keller, Rogeria Caetano, Heliard Rodrigues dos Santos Rufino, Marcos Natal Sanches, Osimar de Carvalho Giometti, Ines Cristina Giuffrida, Rogério Bremer-Neto, Hermann Vet World Research Article BACKGROUND AND AIM: The prebiotics, mannan-oligosaccharides (MOS), demonstrate the ability to increase probiotic microorganisms and fixation and removal of pathogens associated with chronic systemic inflammation in the digestive system. Inflammatory processes play an important role in modulating the brain-intestinal axis, including maintaining male reproductive function and spermatogenesis and regulating stress. The aim of the present study was to evaluate the action of MOS on testosterone and corticosterone concentrations and the reproductive system development of rats in the growth phase as an animal model. MATERIALS AND METHODS: In total, 128 male rats were used, randomly divided into four experimental groups (n=32): Control; MOS 1; MOS 2; and MOS 3. From each group, eight animals were sacrificed in four experimental moments (14, 28, 42, and 56 days, respectively, moments 1, 2, 3, and 4) and hormonal measurements and histological evaluations were performed. RESULTS: The results revealed the effect of diet, MOS, and timing on testicle weight (p<0.05). At moments 3 and 4, the groups supplemented with MOS showed higher concentrations of testosterone and decreased corticosterone levels throughout the experimental period. Groups supplemented with MOS showed an increase in the frequency of relative sperm and sperm scores. The radii of the seminiferous tubules presented a significant statistical effect of the diet, moments, and diet + moment interaction. CONCLUSION: It was concluded that the three different MOS prebiotics brought forward sexual maturity. Veterinary World 2021-05 2021-05-20 /pmc/articles/PMC8243662/ /pubmed/34220123 http://dx.doi.org/10.14202/vetworld.2021.1210-1219 Text en Copyright: © Rodrigues, et al. https://creativecommons.org/licenses/by/4.0/Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Rodrigues, Luiz Eduardo Kishibe, Milena Miyoshi Keller, Rogeria Caetano, Heliard Rodrigues dos Santos Rufino, Marcos Natal Sanches, Osimar de Carvalho Giometti, Ines Cristina Giuffrida, Rogério Bremer-Neto, Hermann Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study |
title | Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study |
title_full | Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study |
title_fullStr | Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study |
title_full_unstemmed | Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study |
title_short | Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study |
title_sort | prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: a randomized preclinical study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243662/ https://www.ncbi.nlm.nih.gov/pubmed/34220123 http://dx.doi.org/10.14202/vetworld.2021.1210-1219 |
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