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Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study

BACKGROUND AND AIM: The prebiotics, mannan-oligosaccharides (MOS), demonstrate the ability to increase probiotic microorganisms and fixation and removal of pathogens associated with chronic systemic inflammation in the digestive system. Inflammatory processes play an important role in modulating the...

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Autores principales: Rodrigues, Luiz Eduardo, Kishibe, Milena Miyoshi, Keller, Rogeria, Caetano, Heliard Rodrigues dos Santos, Rufino, Marcos Natal, Sanches, Osimar de Carvalho, Giometti, Ines Cristina, Giuffrida, Rogério, Bremer-Neto, Hermann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Veterinary World 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243662/
https://www.ncbi.nlm.nih.gov/pubmed/34220123
http://dx.doi.org/10.14202/vetworld.2021.1210-1219
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author Rodrigues, Luiz Eduardo
Kishibe, Milena Miyoshi
Keller, Rogeria
Caetano, Heliard Rodrigues dos Santos
Rufino, Marcos Natal
Sanches, Osimar de Carvalho
Giometti, Ines Cristina
Giuffrida, Rogério
Bremer-Neto, Hermann
author_facet Rodrigues, Luiz Eduardo
Kishibe, Milena Miyoshi
Keller, Rogeria
Caetano, Heliard Rodrigues dos Santos
Rufino, Marcos Natal
Sanches, Osimar de Carvalho
Giometti, Ines Cristina
Giuffrida, Rogério
Bremer-Neto, Hermann
author_sort Rodrigues, Luiz Eduardo
collection PubMed
description BACKGROUND AND AIM: The prebiotics, mannan-oligosaccharides (MOS), demonstrate the ability to increase probiotic microorganisms and fixation and removal of pathogens associated with chronic systemic inflammation in the digestive system. Inflammatory processes play an important role in modulating the brain-intestinal axis, including maintaining male reproductive function and spermatogenesis and regulating stress. The aim of the present study was to evaluate the action of MOS on testosterone and corticosterone concentrations and the reproductive system development of rats in the growth phase as an animal model. MATERIALS AND METHODS: In total, 128 male rats were used, randomly divided into four experimental groups (n=32): Control; MOS 1; MOS 2; and MOS 3. From each group, eight animals were sacrificed in four experimental moments (14, 28, 42, and 56 days, respectively, moments 1, 2, 3, and 4) and hormonal measurements and histological evaluations were performed. RESULTS: The results revealed the effect of diet, MOS, and timing on testicle weight (p<0.05). At moments 3 and 4, the groups supplemented with MOS showed higher concentrations of testosterone and decreased corticosterone levels throughout the experimental period. Groups supplemented with MOS showed an increase in the frequency of relative sperm and sperm scores. The radii of the seminiferous tubules presented a significant statistical effect of the diet, moments, and diet + moment interaction. CONCLUSION: It was concluded that the three different MOS prebiotics brought forward sexual maturity.
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spelling pubmed-82436622021-07-02 Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study Rodrigues, Luiz Eduardo Kishibe, Milena Miyoshi Keller, Rogeria Caetano, Heliard Rodrigues dos Santos Rufino, Marcos Natal Sanches, Osimar de Carvalho Giometti, Ines Cristina Giuffrida, Rogério Bremer-Neto, Hermann Vet World Research Article BACKGROUND AND AIM: The prebiotics, mannan-oligosaccharides (MOS), demonstrate the ability to increase probiotic microorganisms and fixation and removal of pathogens associated with chronic systemic inflammation in the digestive system. Inflammatory processes play an important role in modulating the brain-intestinal axis, including maintaining male reproductive function and spermatogenesis and regulating stress. The aim of the present study was to evaluate the action of MOS on testosterone and corticosterone concentrations and the reproductive system development of rats in the growth phase as an animal model. MATERIALS AND METHODS: In total, 128 male rats were used, randomly divided into four experimental groups (n=32): Control; MOS 1; MOS 2; and MOS 3. From each group, eight animals were sacrificed in four experimental moments (14, 28, 42, and 56 days, respectively, moments 1, 2, 3, and 4) and hormonal measurements and histological evaluations were performed. RESULTS: The results revealed the effect of diet, MOS, and timing on testicle weight (p<0.05). At moments 3 and 4, the groups supplemented with MOS showed higher concentrations of testosterone and decreased corticosterone levels throughout the experimental period. Groups supplemented with MOS showed an increase in the frequency of relative sperm and sperm scores. The radii of the seminiferous tubules presented a significant statistical effect of the diet, moments, and diet + moment interaction. CONCLUSION: It was concluded that the three different MOS prebiotics brought forward sexual maturity. Veterinary World 2021-05 2021-05-20 /pmc/articles/PMC8243662/ /pubmed/34220123 http://dx.doi.org/10.14202/vetworld.2021.1210-1219 Text en Copyright: © Rodrigues, et al. https://creativecommons.org/licenses/by/4.0/Open Access. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Rodrigues, Luiz Eduardo
Kishibe, Milena Miyoshi
Keller, Rogeria
Caetano, Heliard Rodrigues dos Santos
Rufino, Marcos Natal
Sanches, Osimar de Carvalho
Giometti, Ines Cristina
Giuffrida, Rogério
Bremer-Neto, Hermann
Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study
title Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study
title_full Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study
title_fullStr Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study
title_full_unstemmed Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study
title_short Prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: A randomized preclinical study
title_sort prebiotics mannan-oligosaccharides accelerate sexual maturity in rats: a randomized preclinical study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243662/
https://www.ncbi.nlm.nih.gov/pubmed/34220123
http://dx.doi.org/10.14202/vetworld.2021.1210-1219
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