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Cuff-Method Thigh Arterial Occlusion Counteracts Cerebral Hypoperfusion Against the Push–Pull Effect in Humans
Exposure to acute transition from negative (−Gz) to positive (+ Gz) gravity significantly impairs cerebral perfusion in pilots of high-performance aircraft during push—pull maneuver. This push—pull effect may raise the risk for loss of vision or consciousness. The aim of the present study was to exp...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243772/ https://www.ncbi.nlm.nih.gov/pubmed/34220534 http://dx.doi.org/10.3389/fphys.2021.672351 |
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author | Xing, Changyang Gao, Yuan Wang, Xinpei Xing, Wenjuan Liu, Yunnan Lei, Yujia Zhang, Xing Zhang, Shu Yuan, Lijun Gao, Feng |
author_facet | Xing, Changyang Gao, Yuan Wang, Xinpei Xing, Wenjuan Liu, Yunnan Lei, Yujia Zhang, Xing Zhang, Shu Yuan, Lijun Gao, Feng |
author_sort | Xing, Changyang |
collection | PubMed |
description | Exposure to acute transition from negative (−Gz) to positive (+ Gz) gravity significantly impairs cerebral perfusion in pilots of high-performance aircraft during push—pull maneuver. This push—pull effect may raise the risk for loss of vision or consciousness. The aim of the present study was to explore effective countermeasures against cerebral hypoperfusion induced by the push—pull effect. Twenty healthy young volunteers (male, 21 ± 1 year old) were tested during the simulated push–pull maneuver by tilting. A thigh cuff (TC) pressure of 200 mmHg was applied before and during simulated push—pull maneuver (−0.87 to + 1.00 Gz). Beat-to-beat cerebral and systemic hemodynamics were measured continuously. During rapid −Gz to + Gz transition, mean cerebral blood flow velocity (CBFV) was decreased, but to a lesser extent, in the TC bout compared with the control bout (−3.1 ± 4.9 vs. −7.8 ± 4.4 cm/s, P < 0.001). Similarly, brain-level mean blood pressure showed smaller reduction in the TC bout than in the control bout (−46 ± 12 vs. −61 ± 13 mmHg, P < 0.001). The systolic CBFV was lower but diastolic CBFV was higher in the TC bout. The systemic blood pressure response was blunted in the TC bout, along with similar heart rate increase, smaller decrease, and earlier recovery of total peripheral resistance index than control during the gravitational transition. These data demonstrated that restricting thigh blood flow can effectively mitigate the transient cerebral hypoperfusion induced by rapid shift from −Gz to + Gz, characterized by remarkable improvement of cerebral diastolic flow. |
format | Online Article Text |
id | pubmed-8243772 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82437722021-07-01 Cuff-Method Thigh Arterial Occlusion Counteracts Cerebral Hypoperfusion Against the Push–Pull Effect in Humans Xing, Changyang Gao, Yuan Wang, Xinpei Xing, Wenjuan Liu, Yunnan Lei, Yujia Zhang, Xing Zhang, Shu Yuan, Lijun Gao, Feng Front Physiol Physiology Exposure to acute transition from negative (−Gz) to positive (+ Gz) gravity significantly impairs cerebral perfusion in pilots of high-performance aircraft during push—pull maneuver. This push—pull effect may raise the risk for loss of vision or consciousness. The aim of the present study was to explore effective countermeasures against cerebral hypoperfusion induced by the push—pull effect. Twenty healthy young volunteers (male, 21 ± 1 year old) were tested during the simulated push–pull maneuver by tilting. A thigh cuff (TC) pressure of 200 mmHg was applied before and during simulated push—pull maneuver (−0.87 to + 1.00 Gz). Beat-to-beat cerebral and systemic hemodynamics were measured continuously. During rapid −Gz to + Gz transition, mean cerebral blood flow velocity (CBFV) was decreased, but to a lesser extent, in the TC bout compared with the control bout (−3.1 ± 4.9 vs. −7.8 ± 4.4 cm/s, P < 0.001). Similarly, brain-level mean blood pressure showed smaller reduction in the TC bout than in the control bout (−46 ± 12 vs. −61 ± 13 mmHg, P < 0.001). The systolic CBFV was lower but diastolic CBFV was higher in the TC bout. The systemic blood pressure response was blunted in the TC bout, along with similar heart rate increase, smaller decrease, and earlier recovery of total peripheral resistance index than control during the gravitational transition. These data demonstrated that restricting thigh blood flow can effectively mitigate the transient cerebral hypoperfusion induced by rapid shift from −Gz to + Gz, characterized by remarkable improvement of cerebral diastolic flow. Frontiers Media S.A. 2021-06-09 /pmc/articles/PMC8243772/ /pubmed/34220534 http://dx.doi.org/10.3389/fphys.2021.672351 Text en Copyright © 2021 Xing, Gao, Wang, Xing, Liu, Lei, Zhang, Zhang, Yuan and Gao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Xing, Changyang Gao, Yuan Wang, Xinpei Xing, Wenjuan Liu, Yunnan Lei, Yujia Zhang, Xing Zhang, Shu Yuan, Lijun Gao, Feng Cuff-Method Thigh Arterial Occlusion Counteracts Cerebral Hypoperfusion Against the Push–Pull Effect in Humans |
title | Cuff-Method Thigh Arterial Occlusion Counteracts Cerebral Hypoperfusion Against the Push–Pull Effect in Humans |
title_full | Cuff-Method Thigh Arterial Occlusion Counteracts Cerebral Hypoperfusion Against the Push–Pull Effect in Humans |
title_fullStr | Cuff-Method Thigh Arterial Occlusion Counteracts Cerebral Hypoperfusion Against the Push–Pull Effect in Humans |
title_full_unstemmed | Cuff-Method Thigh Arterial Occlusion Counteracts Cerebral Hypoperfusion Against the Push–Pull Effect in Humans |
title_short | Cuff-Method Thigh Arterial Occlusion Counteracts Cerebral Hypoperfusion Against the Push–Pull Effect in Humans |
title_sort | cuff-method thigh arterial occlusion counteracts cerebral hypoperfusion against the push–pull effect in humans |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243772/ https://www.ncbi.nlm.nih.gov/pubmed/34220534 http://dx.doi.org/10.3389/fphys.2021.672351 |
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