Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer’s disease

Several conserved nuclear RNA binding proteins (sut-1, sut-2, and parn-2) control tau aggregation and toxicity in C. elegans, mice, and human cells. MSUT2 protein normally resides in nuclear speckles, membraneless organelles composed of phase-separated RNAs and RNA-binding proteins that mediate crit...

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Detalles Bibliográficos
Autores principales: McMillan, Pamela J., Strovas, Timothy J., Baum, Misa, Mitchell, Brooke K., Eck, Randall J., Hendricks, Nzinga, Wheeler, Jeanna M., Latimer, Caitlin S., Keene, C. Dirk, Kraemer, Brian C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243890/
https://www.ncbi.nlm.nih.gov/pubmed/34187600
http://dx.doi.org/10.1186/s40478-021-01219-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243890/
https://www.ncbi.nlm.nih.gov/pubmed/34187600
http://dx.doi.org/10.1186/s40478-021-01219-1

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