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BCL-xL is correlated with disease severity in neonatal infants with early sepsis

BACKGROUND: Sepsis is the most common cause of morbidity and mortality in neonatal infants. It is essential to find an accurate and sensitive biomarker to confirm and treat neonatal sepsis in order to decrease the rate of mortality. The aim of this study was to investigate the association between di...

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Autores principales: Wenshen, Wu, Qi, Peng, Tianli, Huang, Jinfeng, Liao, Ning, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243905/
https://www.ncbi.nlm.nih.gov/pubmed/34193088
http://dx.doi.org/10.1186/s12887-021-02764-3
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author Wenshen, Wu
Qi, Peng
Tianli, Huang
Jinfeng, Liao
Ning, Li
author_facet Wenshen, Wu
Qi, Peng
Tianli, Huang
Jinfeng, Liao
Ning, Li
author_sort Wenshen, Wu
collection PubMed
description BACKGROUND: Sepsis is the most common cause of morbidity and mortality in neonatal infants. It is essential to find an accurate and sensitive biomarker to confirm and treat neonatal sepsis in order to decrease the rate of mortality. The aim of this study was to investigate the association between disease severity in patients with sepsis and TNF-α, B cell lymphoma-extra-large (BCL-xL), and serum Mitochondrial membrane potential (MMP). METHODS: We investigated the correlation between SNAP-II score and levels of TNF-α, BCL-xL, and MMP-index, respectively. The receiver-operating characteristics (ROC) was to assess the diagnostic value of the the Bcl-xL in the diagnosis of the of septic shock. RESULTS: A total of 37 infants were diagnosed with sepsis. SNAP-II was positively correlated with the level of BCL-xL (r = 0.450, P = 0.006). The area under the BCL-xL curve was 83.0 %, and the 95 % CI was 67.1–93.3 %. The septic shock threshold was > 3.022 ng/mL, and the sensitivity and specificity were 75.0 and 95.2 %, respectively. The positive predictive value was 92.3 %, and the negative predictive value was 83.3 %. Furthermore, the level of SNAP-II was > 10, and BCL-xL was > 3.022 ng/mL as the threshold, and the sensitivity, specificity, positive predictive value, and negative predictive value of septic shock were 93.8 %, 95.2 %, 93.8 %, and 95.2 %, respectively. CONCLUSIONS: BCL-xL is associated with the progression of sepsis. The combination of BCL-xL and SNAP-II could be early predicte the severity of the disease.
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spelling pubmed-82439052021-06-30 BCL-xL is correlated with disease severity in neonatal infants with early sepsis Wenshen, Wu Qi, Peng Tianli, Huang Jinfeng, Liao Ning, Li BMC Pediatr Research BACKGROUND: Sepsis is the most common cause of morbidity and mortality in neonatal infants. It is essential to find an accurate and sensitive biomarker to confirm and treat neonatal sepsis in order to decrease the rate of mortality. The aim of this study was to investigate the association between disease severity in patients with sepsis and TNF-α, B cell lymphoma-extra-large (BCL-xL), and serum Mitochondrial membrane potential (MMP). METHODS: We investigated the correlation between SNAP-II score and levels of TNF-α, BCL-xL, and MMP-index, respectively. The receiver-operating characteristics (ROC) was to assess the diagnostic value of the the Bcl-xL in the diagnosis of the of septic shock. RESULTS: A total of 37 infants were diagnosed with sepsis. SNAP-II was positively correlated with the level of BCL-xL (r = 0.450, P = 0.006). The area under the BCL-xL curve was 83.0 %, and the 95 % CI was 67.1–93.3 %. The septic shock threshold was > 3.022 ng/mL, and the sensitivity and specificity were 75.0 and 95.2 %, respectively. The positive predictive value was 92.3 %, and the negative predictive value was 83.3 %. Furthermore, the level of SNAP-II was > 10, and BCL-xL was > 3.022 ng/mL as the threshold, and the sensitivity, specificity, positive predictive value, and negative predictive value of septic shock were 93.8 %, 95.2 %, 93.8 %, and 95.2 %, respectively. CONCLUSIONS: BCL-xL is associated with the progression of sepsis. The combination of BCL-xL and SNAP-II could be early predicte the severity of the disease. BioMed Central 2021-06-30 /pmc/articles/PMC8243905/ /pubmed/34193088 http://dx.doi.org/10.1186/s12887-021-02764-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Wenshen, Wu
Qi, Peng
Tianli, Huang
Jinfeng, Liao
Ning, Li
BCL-xL is correlated with disease severity in neonatal infants with early sepsis
title BCL-xL is correlated with disease severity in neonatal infants with early sepsis
title_full BCL-xL is correlated with disease severity in neonatal infants with early sepsis
title_fullStr BCL-xL is correlated with disease severity in neonatal infants with early sepsis
title_full_unstemmed BCL-xL is correlated with disease severity in neonatal infants with early sepsis
title_short BCL-xL is correlated with disease severity in neonatal infants with early sepsis
title_sort bcl-xl is correlated with disease severity in neonatal infants with early sepsis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243905/
https://www.ncbi.nlm.nih.gov/pubmed/34193088
http://dx.doi.org/10.1186/s12887-021-02764-3
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