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(31)P magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations

Skeletal muscle phosphorus‐31 (31)P MRS is the oldest MRS methodology to be applied to in vivo metabolic research. The technical requirements of (31)P MRS in skeletal muscle depend on the research question, and to assess those questions requires understanding both the relevant muscle physiology, and...

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Autores principales: Meyerspeer, Martin, Boesch, Chris, Cameron, Donnie, Dezortová, Monika, Forbes, Sean C., Heerschap, Arend, Jeneson, Jeroen A.L., Kan, Hermien E., Kent, Jane, Layec, Gwenaël, Prompers, Jeanine J., Reyngoudt, Harmen, Sleigh, Alison, Valkovič, Ladislav, Kemp, Graham J., Baligand, Céline, Carlier, Pierre G., Chatel, Benjamin, Damon, Bruce, Heskamp, Linda, Hájek, Milan, Jooijmans, Melissa, Krssak, Martin, Reichenbach, Juergen, Schmid, Albrecht, Slade, Jill, Vandenborne, Krista, Walter, Glenn A., Willis, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243949/
https://www.ncbi.nlm.nih.gov/pubmed/32037688
http://dx.doi.org/10.1002/nbm.4246
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author Meyerspeer, Martin
Boesch, Chris
Cameron, Donnie
Dezortová, Monika
Forbes, Sean C.
Heerschap, Arend
Jeneson, Jeroen A.L.
Kan, Hermien E.
Kent, Jane
Layec, Gwenaël
Prompers, Jeanine J.
Reyngoudt, Harmen
Sleigh, Alison
Valkovič, Ladislav
Kemp, Graham J.
Baligand, Céline
Carlier, Pierre G.
Chatel, Benjamin
Damon, Bruce
Heskamp, Linda
Hájek, Milan
Jooijmans, Melissa
Krssak, Martin
Reichenbach, Juergen
Schmid, Albrecht
Slade, Jill
Vandenborne, Krista
Walter, Glenn A.
Willis, David
author_facet Meyerspeer, Martin
Boesch, Chris
Cameron, Donnie
Dezortová, Monika
Forbes, Sean C.
Heerschap, Arend
Jeneson, Jeroen A.L.
Kan, Hermien E.
Kent, Jane
Layec, Gwenaël
Prompers, Jeanine J.
Reyngoudt, Harmen
Sleigh, Alison
Valkovič, Ladislav
Kemp, Graham J.
Baligand, Céline
Carlier, Pierre G.
Chatel, Benjamin
Damon, Bruce
Heskamp, Linda
Hájek, Milan
Jooijmans, Melissa
Krssak, Martin
Reichenbach, Juergen
Schmid, Albrecht
Slade, Jill
Vandenborne, Krista
Walter, Glenn A.
Willis, David
author_sort Meyerspeer, Martin
collection PubMed
description Skeletal muscle phosphorus‐31 (31)P MRS is the oldest MRS methodology to be applied to in vivo metabolic research. The technical requirements of (31)P MRS in skeletal muscle depend on the research question, and to assess those questions requires understanding both the relevant muscle physiology, and how (31)P MRS methods can probe it. Here we consider basic signal‐acquisition parameters related to radio frequency excitation, TR, TE, spectral resolution, shim and localisation. We make specific recommendations for studies of resting and exercising muscle, including magnetisation transfer, and for data processing. We summarise the metabolic information that can be quantitatively assessed with (31)P MRS, either measured directly or derived by calculations that depend on particular metabolic models, and we give advice on potential problems of interpretation. We give expected values and tolerable ranges for some measured quantities, and minimum requirements for reporting acquisition parameters and experimental results in publications. Reliable examination depends on a reproducible setup, standardised preconditioning of the subject, and careful control of potential difficulties, and we summarise some important considerations and potential confounders. Our recommendations include the quantification and standardisation of contraction intensity, and how best to account for heterogeneous muscle recruitment. We highlight some pitfalls in the assessment of mitochondrial function by analysis of phosphocreatine (PCr) recovery kinetics. Finally, we outline how complementary techniques (near‐infrared spectroscopy, arterial spin labelling, BOLD and various other MRI and (1)H MRS measurements) can help in the physiological/metabolic interpretation of (31)P MRS studies by providing information about blood flow and oxygen delivery/utilisation. Our recommendations will assist in achieving the fullest possible reliable picture of muscle physiology and pathophysiology.
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spelling pubmed-82439492021-07-02 (31)P magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations Meyerspeer, Martin Boesch, Chris Cameron, Donnie Dezortová, Monika Forbes, Sean C. Heerschap, Arend Jeneson, Jeroen A.L. Kan, Hermien E. Kent, Jane Layec, Gwenaël Prompers, Jeanine J. Reyngoudt, Harmen Sleigh, Alison Valkovič, Ladislav Kemp, Graham J. Baligand, Céline Carlier, Pierre G. Chatel, Benjamin Damon, Bruce Heskamp, Linda Hájek, Milan Jooijmans, Melissa Krssak, Martin Reichenbach, Juergen Schmid, Albrecht Slade, Jill Vandenborne, Krista Walter, Glenn A. Willis, David NMR Biomed Special Issue Review Articles Skeletal muscle phosphorus‐31 (31)P MRS is the oldest MRS methodology to be applied to in vivo metabolic research. The technical requirements of (31)P MRS in skeletal muscle depend on the research question, and to assess those questions requires understanding both the relevant muscle physiology, and how (31)P MRS methods can probe it. Here we consider basic signal‐acquisition parameters related to radio frequency excitation, TR, TE, spectral resolution, shim and localisation. We make specific recommendations for studies of resting and exercising muscle, including magnetisation transfer, and for data processing. We summarise the metabolic information that can be quantitatively assessed with (31)P MRS, either measured directly or derived by calculations that depend on particular metabolic models, and we give advice on potential problems of interpretation. We give expected values and tolerable ranges for some measured quantities, and minimum requirements for reporting acquisition parameters and experimental results in publications. Reliable examination depends on a reproducible setup, standardised preconditioning of the subject, and careful control of potential difficulties, and we summarise some important considerations and potential confounders. Our recommendations include the quantification and standardisation of contraction intensity, and how best to account for heterogeneous muscle recruitment. We highlight some pitfalls in the assessment of mitochondrial function by analysis of phosphocreatine (PCr) recovery kinetics. Finally, we outline how complementary techniques (near‐infrared spectroscopy, arterial spin labelling, BOLD and various other MRI and (1)H MRS measurements) can help in the physiological/metabolic interpretation of (31)P MRS studies by providing information about blood flow and oxygen delivery/utilisation. Our recommendations will assist in achieving the fullest possible reliable picture of muscle physiology and pathophysiology. John Wiley and Sons Inc. 2020-02-10 2021-05 /pmc/articles/PMC8243949/ /pubmed/32037688 http://dx.doi.org/10.1002/nbm.4246 Text en © 2020 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Special Issue Review Articles
Meyerspeer, Martin
Boesch, Chris
Cameron, Donnie
Dezortová, Monika
Forbes, Sean C.
Heerschap, Arend
Jeneson, Jeroen A.L.
Kan, Hermien E.
Kent, Jane
Layec, Gwenaël
Prompers, Jeanine J.
Reyngoudt, Harmen
Sleigh, Alison
Valkovič, Ladislav
Kemp, Graham J.
Baligand, Céline
Carlier, Pierre G.
Chatel, Benjamin
Damon, Bruce
Heskamp, Linda
Hájek, Milan
Jooijmans, Melissa
Krssak, Martin
Reichenbach, Juergen
Schmid, Albrecht
Slade, Jill
Vandenborne, Krista
Walter, Glenn A.
Willis, David
(31)P magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations
title (31)P magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations
title_full (31)P magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations
title_fullStr (31)P magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations
title_full_unstemmed (31)P magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations
title_short (31)P magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations
title_sort (31)p magnetic resonance spectroscopy in skeletal muscle: experts' consensus recommendations
topic Special Issue Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243949/
https://www.ncbi.nlm.nih.gov/pubmed/32037688
http://dx.doi.org/10.1002/nbm.4246
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