Cargando…
(31)P magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations
Skeletal muscle phosphorus‐31 (31)P MRS is the oldest MRS methodology to be applied to in vivo metabolic research. The technical requirements of (31)P MRS in skeletal muscle depend on the research question, and to assess those questions requires understanding both the relevant muscle physiology, and...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243949/ https://www.ncbi.nlm.nih.gov/pubmed/32037688 http://dx.doi.org/10.1002/nbm.4246 |
_version_ | 1783715832340152320 |
---|---|
author | Meyerspeer, Martin Boesch, Chris Cameron, Donnie Dezortová, Monika Forbes, Sean C. Heerschap, Arend Jeneson, Jeroen A.L. Kan, Hermien E. Kent, Jane Layec, Gwenaël Prompers, Jeanine J. Reyngoudt, Harmen Sleigh, Alison Valkovič, Ladislav Kemp, Graham J. Baligand, Céline Carlier, Pierre G. Chatel, Benjamin Damon, Bruce Heskamp, Linda Hájek, Milan Jooijmans, Melissa Krssak, Martin Reichenbach, Juergen Schmid, Albrecht Slade, Jill Vandenborne, Krista Walter, Glenn A. Willis, David |
author_facet | Meyerspeer, Martin Boesch, Chris Cameron, Donnie Dezortová, Monika Forbes, Sean C. Heerschap, Arend Jeneson, Jeroen A.L. Kan, Hermien E. Kent, Jane Layec, Gwenaël Prompers, Jeanine J. Reyngoudt, Harmen Sleigh, Alison Valkovič, Ladislav Kemp, Graham J. Baligand, Céline Carlier, Pierre G. Chatel, Benjamin Damon, Bruce Heskamp, Linda Hájek, Milan Jooijmans, Melissa Krssak, Martin Reichenbach, Juergen Schmid, Albrecht Slade, Jill Vandenborne, Krista Walter, Glenn A. Willis, David |
author_sort | Meyerspeer, Martin |
collection | PubMed |
description | Skeletal muscle phosphorus‐31 (31)P MRS is the oldest MRS methodology to be applied to in vivo metabolic research. The technical requirements of (31)P MRS in skeletal muscle depend on the research question, and to assess those questions requires understanding both the relevant muscle physiology, and how (31)P MRS methods can probe it. Here we consider basic signal‐acquisition parameters related to radio frequency excitation, TR, TE, spectral resolution, shim and localisation. We make specific recommendations for studies of resting and exercising muscle, including magnetisation transfer, and for data processing. We summarise the metabolic information that can be quantitatively assessed with (31)P MRS, either measured directly or derived by calculations that depend on particular metabolic models, and we give advice on potential problems of interpretation. We give expected values and tolerable ranges for some measured quantities, and minimum requirements for reporting acquisition parameters and experimental results in publications. Reliable examination depends on a reproducible setup, standardised preconditioning of the subject, and careful control of potential difficulties, and we summarise some important considerations and potential confounders. Our recommendations include the quantification and standardisation of contraction intensity, and how best to account for heterogeneous muscle recruitment. We highlight some pitfalls in the assessment of mitochondrial function by analysis of phosphocreatine (PCr) recovery kinetics. Finally, we outline how complementary techniques (near‐infrared spectroscopy, arterial spin labelling, BOLD and various other MRI and (1)H MRS measurements) can help in the physiological/metabolic interpretation of (31)P MRS studies by providing information about blood flow and oxygen delivery/utilisation. Our recommendations will assist in achieving the fullest possible reliable picture of muscle physiology and pathophysiology. |
format | Online Article Text |
id | pubmed-8243949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82439492021-07-02 (31)P magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations Meyerspeer, Martin Boesch, Chris Cameron, Donnie Dezortová, Monika Forbes, Sean C. Heerschap, Arend Jeneson, Jeroen A.L. Kan, Hermien E. Kent, Jane Layec, Gwenaël Prompers, Jeanine J. Reyngoudt, Harmen Sleigh, Alison Valkovič, Ladislav Kemp, Graham J. Baligand, Céline Carlier, Pierre G. Chatel, Benjamin Damon, Bruce Heskamp, Linda Hájek, Milan Jooijmans, Melissa Krssak, Martin Reichenbach, Juergen Schmid, Albrecht Slade, Jill Vandenborne, Krista Walter, Glenn A. Willis, David NMR Biomed Special Issue Review Articles Skeletal muscle phosphorus‐31 (31)P MRS is the oldest MRS methodology to be applied to in vivo metabolic research. The technical requirements of (31)P MRS in skeletal muscle depend on the research question, and to assess those questions requires understanding both the relevant muscle physiology, and how (31)P MRS methods can probe it. Here we consider basic signal‐acquisition parameters related to radio frequency excitation, TR, TE, spectral resolution, shim and localisation. We make specific recommendations for studies of resting and exercising muscle, including magnetisation transfer, and for data processing. We summarise the metabolic information that can be quantitatively assessed with (31)P MRS, either measured directly or derived by calculations that depend on particular metabolic models, and we give advice on potential problems of interpretation. We give expected values and tolerable ranges for some measured quantities, and minimum requirements for reporting acquisition parameters and experimental results in publications. Reliable examination depends on a reproducible setup, standardised preconditioning of the subject, and careful control of potential difficulties, and we summarise some important considerations and potential confounders. Our recommendations include the quantification and standardisation of contraction intensity, and how best to account for heterogeneous muscle recruitment. We highlight some pitfalls in the assessment of mitochondrial function by analysis of phosphocreatine (PCr) recovery kinetics. Finally, we outline how complementary techniques (near‐infrared spectroscopy, arterial spin labelling, BOLD and various other MRI and (1)H MRS measurements) can help in the physiological/metabolic interpretation of (31)P MRS studies by providing information about blood flow and oxygen delivery/utilisation. Our recommendations will assist in achieving the fullest possible reliable picture of muscle physiology and pathophysiology. John Wiley and Sons Inc. 2020-02-10 2021-05 /pmc/articles/PMC8243949/ /pubmed/32037688 http://dx.doi.org/10.1002/nbm.4246 Text en © 2020 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Special Issue Review Articles Meyerspeer, Martin Boesch, Chris Cameron, Donnie Dezortová, Monika Forbes, Sean C. Heerschap, Arend Jeneson, Jeroen A.L. Kan, Hermien E. Kent, Jane Layec, Gwenaël Prompers, Jeanine J. Reyngoudt, Harmen Sleigh, Alison Valkovič, Ladislav Kemp, Graham J. Baligand, Céline Carlier, Pierre G. Chatel, Benjamin Damon, Bruce Heskamp, Linda Hájek, Milan Jooijmans, Melissa Krssak, Martin Reichenbach, Juergen Schmid, Albrecht Slade, Jill Vandenborne, Krista Walter, Glenn A. Willis, David (31)P magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations |
title |
(31)P magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations |
title_full |
(31)P magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations |
title_fullStr |
(31)P magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations |
title_full_unstemmed |
(31)P magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations |
title_short |
(31)P magnetic resonance spectroscopy in skeletal muscle: Experts' consensus recommendations |
title_sort | (31)p magnetic resonance spectroscopy in skeletal muscle: experts' consensus recommendations |
topic | Special Issue Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8243949/ https://www.ncbi.nlm.nih.gov/pubmed/32037688 http://dx.doi.org/10.1002/nbm.4246 |
work_keys_str_mv | AT meyerspeermartin 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT boeschchris 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT camerondonnie 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT dezortovamonika 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT forbesseanc 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT heerschaparend 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT jenesonjeroenal 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT kanhermiene 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT kentjane 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT layecgwenael 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT prompersjeaninej 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT reyngoudtharmen 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT sleighalison 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT valkovicladislav 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT kempgrahamj 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT baligandceline 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT carlierpierreg 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT chatelbenjamin 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT damonbruce 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT heskamplinda 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT hajekmilan 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT jooijmansmelissa 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT krssakmartin 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT reichenbachjuergen 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT schmidalbrecht 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT sladejill 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT vandenbornekrista 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT walterglenna 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations AT willisdavid 31pmagneticresonancespectroscopyinskeletalmuscleexpertsconsensusrecommendations |