Cargando…

A phenome-wide association study of genetically mimicked statins

BACKGROUND: Beyond their success in cardiovascular disease prevention, statins are increasingly recognized to have sex-specific pleiotropic effects. To gain additional insight, we characterized associations of genetically mimicked statins across the phenotype sex-specifically. We also assessed wheth...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Shun, Schooling, C. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244164/ https://www.ncbi.nlm.nih.gov/pubmed/34187478 http://dx.doi.org/10.1186/s12916-021-02013-5

Ejemplares similares

A phenome-wide association study of ABO blood groups
por: Li, Shun, et al.
Publicado: (2020)

Genetically mimicked effects of ASGR1 inhibitors on all-cause mortality and health outcomes: a drug-target Mendelian randomization study and a phenome-wide association study
por: Yang, Guoyi, et al.
Publicado: (2023)

Investigating genetically mimicked effects of statins via HMGCR inhibition on immune-related diseases in men and women using Mendelian randomization
por: Yang, Guoyi, et al.
Publicado: (2021)

Phenome‐Wide Association Study of Severe COVID‐19 Genetic Risk Variants
por: Regan, Jessica A., et al.
Publicado: (2022)

Enhanced rare disease mapping for phenome-wide genetic association in the UK Biobank
por: Patrick, Matthew T., et al.
Publicado: (2022)

Investigating the effects of statins on ischemic heart disease allowing for effects on body mass index: a Mendelian randomization study
por: Li, Shun, et al.
Publicado: (2022)

Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness
por: Abdellaoui, Abdel, et al.
Publicado: (2019)

The challenges, advantages and future of phenome-wide association studies
por: Hebbring, Scott J
Publicado: (2014)

Human genetic determinants of the gut microbiome and their associations with health and disease: a phenome-wide association study
por: Groot, Hilde E., et al.
Publicado: (2020)

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
por: Schmidt, Amand F., et al.
Publicado: (2019)

Joy of Ping-Pong: Genome-Wide and Phenome-Wide Association Studies
por: Park, Heung-Woo
Publicado: (2020)

A multi-population phenome-wide association study of genetically-predicted height in the Million Veteran Program
por: Raghavan, Sridharan, et al.
Publicado: (2022)

A simulation study investigating power estimates in phenome-wide association studies
por: Verma, Anurag, et al.
Publicado: (2018)

Microbiome-associated human genetic variants impact phenome-wide disease risk
por: Markowitz, Robert H. George, et al.
Publicado: (2022)

EHR-based phenome wide association study in pancreatic cancer
por: Adamusiak, Tomasz, et al.
Publicado: (2014)

Genome–phenome wide association study of broadly defined headache
por: Hsu, Wan-Ting, et al.
Publicado: (2023)

Phenome-wide heritability analysis of the UK Biobank
por: Ge, Tian, et al.
Publicado: (2017)

Towards a phenome-wide catalog of human clinical traits impacted by genetic ancestry
por: Dumitrescu, Logan, et al.
Publicado: (2015)

Allergy-specific Phenome-Wide Association Study for Immunogenes in Turkish Children
por: Karaca, Sefayet, et al.
Publicado: (2016)

HCLC-FC: A novel statistical method for phenome-wide association studies
por: Liang, Xiaoyu, et al.
Publicado: (2022)

Health effects of milk consumption: phenome-wide Mendelian randomization study
por: Yuan, Shuai, et al.
Publicado: (2022)

Phenome-wide analysis of genome-wide polygenic scores
por: Krapohl, E, et al.
Publicado: (2016)

Polygenic risk score phenome-wide association study reveals an association between endometriosis and testosterone
por: McGrath, Isabelle M., et al.
Publicado: (2023)

Phenome-Wide Association Study to Explore Relationships between Immune System Related Genetic Loci and Complex Traits and Diseases
por: Verma, Anurag, et al.
Publicado: (2016)

Phenome-wide and expression quantitative trait locus associations of coronavirus disease 2019 genetic risk loci
por: Moon, Chang Yoon, et al.
Publicado: (2021)

Phenome-wide Investigation of Behavioral, Environmental, and Neural Associations with Cross-Disorder Genetic Liability in Youth of European Ancestry
por: Paul, Sarah E., et al.
Publicado: (2023)

Identifying shared genetic architecture between rheumatoid arthritis and other conditions: a phenome-wide association study with genetic risk scores
por: Zhang, Harrison G., et al.
Publicado: (2023)

Phenome-wide association study on miRNA-related sequence variants: the UK Biobank
por: Mustafa, Rima, et al.
Publicado: (2023)

Phenome-wide genetic-correlation analysis and genetically informed causal inference of amyotrophic lateral sclerosis
por: D’Antona, Salvatore, et al.
Publicado: (2023)

Phenome-wide and genome-wide analyses of quality of life in schizophrenia
por: Pazoki, Raha, et al.
Publicado: (2020)

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank
por: Shen, Xueyi, et al.
Publicado: (2020)

A phenome-wide scan reveals convergence of common and rare variant associations
por: Zhou, Dan, et al.
Publicado: (2023)

A Phenome-Wide Association Study of genes associated with COVID-19 severity reveals shared genetics with complex diseases in the Million Veteran Program
por: Verma, Anurag, et al.
Publicado: (2022)

Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index
por: Cronin, Robert M., et al.
Publicado: (2014)

Investigating the relationship between mitochondrial genetic variation and cardiovascular-related traits to develop a framework for mitochondrial phenome-wide association studies
por: Mitchell, Sabrina L, et al.
Publicado: (2014)

A phenome-wide examination of neural and cognitive function
por: Poldrack, R.A., et al.
Publicado: (2016)

Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation
por: Yuan, Shuai, et al.
Publicado: (2022)

A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes
por: Coral, Daniel E., et al.
Publicado: (2023)

Phenome‐Wide Association Study of Autoantibodies to Citrullinated and Noncitrullinated Epitopes in Rheumatoid Arthritis
por: Liao, Katherine P., et al.
Publicado: (2017)

A phenome-wide association study to discover pleiotropic effects of PCSK9, APOB, and LDLR
por: Safarova, Maya S., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_tjap7aq4b3cajjolr6qlgr5hv4