Follicle-stimulating hormone receptor autoantibody associated primary ovarian insufficiency successfully treated with corticosteroids: a case report

OBJECTIVE: To report a case of successful controlled ovarian stimulation (COH) for oocyte cryopreservation in a patient with autoimmune primary ovarian insufficiency (POI) and polyglandular autoimmune syndrome (PGAS) type 2. DESIGN: Case report. SETTING: Private in vitro fertilization clinic. PATIENT(S): 25-Year-old woman, G0, with autoimmune POI and PGAS type 2. INTERVENTION(S): Diagnosis of autoimmune interference with FSH signaling, with subsequent high-dose corticosteroid immune suppression and successful oocyte cryopreservation. MAIN OUTCOMES MEASURE(S): Successful stimulation with exogenous gonadotropins, oocyte retrieval, and cryopreservation. RESULT(S): Retrieval and cryopreservation of 36 metaphase-II (MII) oocytes. CONCLUSION(S): Scrutiny of POI cases will facilitate identification of a subset of patients in whom immune suppression with short-term, high-dose corticosteroids may enable successful COH.