Cargando…
Sperm morphology from the actual inseminated sample does not predict clinical pregnancy following intrauterine insemination
OBJECTIVE: To determine the effect of sperm morphology from the specific sample used for intrauterine insemination (IUI) on clinical pregnancy rates (CPR). DESIGN: Prospective cohort study. SETTING: Academic fertility clinic. PATIENT(S): Couples undergoing IUI July 2016–January 2017. INTERVENTION(S)...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244316/ https://www.ncbi.nlm.nih.gov/pubmed/34223268 http://dx.doi.org/10.1016/j.xfre.2020.11.007 |
_version_ | 1783715909724012544 |
---|---|
author | Stanhiser, Jamie Mersereau, Jennifer E. Dock, Daquan Boylan, Caitlin Caprell, Hunter Coward, R. Matthew Berger, Dara S. Fritz, Marc |
author_facet | Stanhiser, Jamie Mersereau, Jennifer E. Dock, Daquan Boylan, Caitlin Caprell, Hunter Coward, R. Matthew Berger, Dara S. Fritz, Marc |
author_sort | Stanhiser, Jamie |
collection | PubMed |
description | OBJECTIVE: To determine the effect of sperm morphology from the specific sample used for intrauterine insemination (IUI) on clinical pregnancy rates (CPR). DESIGN: Prospective cohort study. SETTING: Academic fertility clinic. PATIENT(S): Couples undergoing IUI July 2016–January 2017. INTERVENTION(S): Morphology slides were prepared from the semen sample produced for IUI. MAIN OUTCOME MEASURE(S): CPR was measured by detection of cardiac activity. Multiple logistic regression modeling was performed to determine the association of sperm morphology with CPR, controlling for age, antimüllerian hormone level, and post-wash total motile sperm count. RESULT(S): Semen analyses, including Kruger strict criteria for morphology from the actual sample inseminated, were reviewed for 155 couples, comprising 234 total treatment cycles. The percent normal morphology significantly differed between the preliminary semen analysis and the IUI sample (−2.0% +3.7% (95% CI −2.55, −1.53). Of the total 234 treatment cycles, 8.6% resulted in clinical pregnancy. When categorized by strict morphology >4%, <4%, and <1%, the CPR was 6.6%, 9.8%, and 10.9%, respectively. In couples with otherwise normal semen parameters (isolated teratospermia), CPR by >4%, <4%, and <1% normal forms was 7.2%, 9.8%, and 11.1%, respectively. There was no significant association between the percent normal morphology and CPR in multivariate analysis. CONCLUSION(S): This study evaluating the morphology of the actual inseminated sample did not find differences in CPR following IUI among couples with normal and abnormal sperm morphology, including severe teratospermia. Abnormal sperm morphology should not exclude couples from attempting IUI. |
format | Online Article Text |
id | pubmed-8244316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-82443162021-07-02 Sperm morphology from the actual inseminated sample does not predict clinical pregnancy following intrauterine insemination Stanhiser, Jamie Mersereau, Jennifer E. Dock, Daquan Boylan, Caitlin Caprell, Hunter Coward, R. Matthew Berger, Dara S. Fritz, Marc F S Rep Original Article OBJECTIVE: To determine the effect of sperm morphology from the specific sample used for intrauterine insemination (IUI) on clinical pregnancy rates (CPR). DESIGN: Prospective cohort study. SETTING: Academic fertility clinic. PATIENT(S): Couples undergoing IUI July 2016–January 2017. INTERVENTION(S): Morphology slides were prepared from the semen sample produced for IUI. MAIN OUTCOME MEASURE(S): CPR was measured by detection of cardiac activity. Multiple logistic regression modeling was performed to determine the association of sperm morphology with CPR, controlling for age, antimüllerian hormone level, and post-wash total motile sperm count. RESULT(S): Semen analyses, including Kruger strict criteria for morphology from the actual sample inseminated, were reviewed for 155 couples, comprising 234 total treatment cycles. The percent normal morphology significantly differed between the preliminary semen analysis and the IUI sample (−2.0% +3.7% (95% CI −2.55, −1.53). Of the total 234 treatment cycles, 8.6% resulted in clinical pregnancy. When categorized by strict morphology >4%, <4%, and <1%, the CPR was 6.6%, 9.8%, and 10.9%, respectively. In couples with otherwise normal semen parameters (isolated teratospermia), CPR by >4%, <4%, and <1% normal forms was 7.2%, 9.8%, and 11.1%, respectively. There was no significant association between the percent normal morphology and CPR in multivariate analysis. CONCLUSION(S): This study evaluating the morphology of the actual inseminated sample did not find differences in CPR following IUI among couples with normal and abnormal sperm morphology, including severe teratospermia. Abnormal sperm morphology should not exclude couples from attempting IUI. Elsevier 2020-12-09 /pmc/articles/PMC8244316/ /pubmed/34223268 http://dx.doi.org/10.1016/j.xfre.2020.11.007 Text en © 2020 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Stanhiser, Jamie Mersereau, Jennifer E. Dock, Daquan Boylan, Caitlin Caprell, Hunter Coward, R. Matthew Berger, Dara S. Fritz, Marc Sperm morphology from the actual inseminated sample does not predict clinical pregnancy following intrauterine insemination |
title | Sperm morphology from the actual inseminated sample does not predict clinical pregnancy following intrauterine insemination |
title_full | Sperm morphology from the actual inseminated sample does not predict clinical pregnancy following intrauterine insemination |
title_fullStr | Sperm morphology from the actual inseminated sample does not predict clinical pregnancy following intrauterine insemination |
title_full_unstemmed | Sperm morphology from the actual inseminated sample does not predict clinical pregnancy following intrauterine insemination |
title_short | Sperm morphology from the actual inseminated sample does not predict clinical pregnancy following intrauterine insemination |
title_sort | sperm morphology from the actual inseminated sample does not predict clinical pregnancy following intrauterine insemination |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244316/ https://www.ncbi.nlm.nih.gov/pubmed/34223268 http://dx.doi.org/10.1016/j.xfre.2020.11.007 |
work_keys_str_mv | AT stanhiserjamie spermmorphologyfromtheactualinseminatedsampledoesnotpredictclinicalpregnancyfollowingintrauterineinsemination AT mersereaujennifere spermmorphologyfromtheactualinseminatedsampledoesnotpredictclinicalpregnancyfollowingintrauterineinsemination AT dockdaquan spermmorphologyfromtheactualinseminatedsampledoesnotpredictclinicalpregnancyfollowingintrauterineinsemination AT boylancaitlin spermmorphologyfromtheactualinseminatedsampledoesnotpredictclinicalpregnancyfollowingintrauterineinsemination AT caprellhunter spermmorphologyfromtheactualinseminatedsampledoesnotpredictclinicalpregnancyfollowingintrauterineinsemination AT cowardrmatthew spermmorphologyfromtheactualinseminatedsampledoesnotpredictclinicalpregnancyfollowingintrauterineinsemination AT bergerdaras spermmorphologyfromtheactualinseminatedsampledoesnotpredictclinicalpregnancyfollowingintrauterineinsemination AT fritzmarc spermmorphologyfromtheactualinseminatedsampledoesnotpredictclinicalpregnancyfollowingintrauterineinsemination |