Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery

Energy-dependent Lon proteases play a key role in cellular regulation by degrading short-lived regulatory proteins and misfolded proteins in the cell. The structure of the catalytically inactive S679A mutant of Escherichia coli LonA protease (EcLon) has been determined by cryo-EM at the resolution o...

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Detalles Bibliográficos
Autores principales: Botos, Istvan, Lountos, George T., Wu, Weimin, Cherry, Scott, Ghirlando, Rodolfo, Kudzhaev, Arsen M., Rotanova, Tatyana V., de Val, Natalia, Tropea, Joseph E., Gustchina, Alla, Wlodawer, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244335/
https://www.ncbi.nlm.nih.gov/pubmed/34235464
http://dx.doi.org/10.1016/j.crstbi.2019.10.001

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