Dose optimization of early high-dose valproic acid for neuroprotection in a swine cardiac arrest model

AIM: High-dose valproic acid (VPA) improves the survival and neurologic outcomes after asphyxial cardiac arrest (CA) in rats. We characterized the pharmacokinetics, pharmacodynamics, and safety of high-dose VPA in a swine CA model to advance clinical translation. METHODS: After 8 ​min of untreated v...

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Detalles Bibliográficos
Autores principales: Hsu, Cindy H., Tiba, Mohamad H., McCracken, Brendan M., Colmenero, Carmen I., Pickell, Zachary, Leander, Danielle C., Weitzel, Anne M., Raghunayakula, Sarita, Liao, Jinhui, Jinka, Tulasi, Cummings, Brandon C., Pai, Manjunath P., Alam, Hasan B., Ward, Kevin R., Sanderson, Thomas H., Neumar, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Experimental Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244526/
https://www.ncbi.nlm.nih.gov/pubmed/34223294
http://dx.doi.org/10.1016/j.resplu.2020.100007

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