Plasma exchange with COVID-19 convalescent plasma in a patient with severe ANCA-associated vasculitis and COVID-19 pneumonia after rituximab therapy

The combination of coronavirus disease 2019 (COVID-19) pneumonia and pulmonary–renal syndrome due to ANCA‐associated vasculitis (AAV) poses diagnostic uncertainty and a therapeutic dilemma. According to current limited knowledge of COVID-19, the application of commonly used drugs in AAV, cyclophosph...

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Autores principales: Kochanek, Matthias, Garcia Borrega, Jorge, Beckmann, Laura, Neuhann, Julia, Gathof, Birgit S, Di Cristanziano, Veronica, Hagmann, Henning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Exceptional Case
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244539/
https://www.ncbi.nlm.nih.gov/pubmed/35028131
http://dx.doi.org/10.1093/ckj/sfab095
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author Kochanek, Matthias
Garcia Borrega, Jorge
Beckmann, Laura
Neuhann, Julia
Gathof, Birgit S
Di Cristanziano, Veronica
Hagmann, Henning
author_facet Kochanek, Matthias
Garcia Borrega, Jorge
Beckmann, Laura
Neuhann, Julia
Gathof, Birgit S
Di Cristanziano, Veronica
Hagmann, Henning
author_sort Kochanek, Matthias
collection PubMed
description The combination of coronavirus disease 2019 (COVID-19) pneumonia and pulmonary–renal syndrome due to ANCA‐associated vasculitis (AAV) poses diagnostic uncertainty and a therapeutic dilemma. According to current limited knowledge of COVID-19, the application of commonly used drugs in AAV, cyclophosphamide (CYC) and rituximab (RTX), must be weighed carefully in active COVID-19 infection. We report a case of a 52-year-old male patient with concurrent severe COVID-19 pneumonia and acute relapse of pulmonary–renal syndrome due to AAV after recent RTX maintenance dose. The patient presented with severe hypoxaemia, complete B-cell depletion and severe acute respiratory syndrome coronavirus 2 viraemia. He was successfully treated with therapeutic plasma exchange employing COVID-19 convalescent plasma.
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spelling pubmed-82445392021-07-01 Plasma exchange with COVID-19 convalescent plasma in a patient with severe ANCA-associated vasculitis and COVID-19 pneumonia after rituximab therapy Kochanek, Matthias Garcia Borrega, Jorge Beckmann, Laura Neuhann, Julia Gathof, Birgit S Di Cristanziano, Veronica Hagmann, Henning Clin Kidney J Exceptional Case The combination of coronavirus disease 2019 (COVID-19) pneumonia and pulmonary–renal syndrome due to ANCA‐associated vasculitis (AAV) poses diagnostic uncertainty and a therapeutic dilemma. According to current limited knowledge of COVID-19, the application of commonly used drugs in AAV, cyclophosphamide (CYC) and rituximab (RTX), must be weighed carefully in active COVID-19 infection. We report a case of a 52-year-old male patient with concurrent severe COVID-19 pneumonia and acute relapse of pulmonary–renal syndrome due to AAV after recent RTX maintenance dose. The patient presented with severe hypoxaemia, complete B-cell depletion and severe acute respiratory syndrome coronavirus 2 viraemia. He was successfully treated with therapeutic plasma exchange employing COVID-19 convalescent plasma. Oxford University Press 2021-05-27 /pmc/articles/PMC8244539/ /pubmed/35028131 http://dx.doi.org/10.1093/ckj/sfab095 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of ERA. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Exceptional Case
Kochanek, Matthias
Garcia Borrega, Jorge
Beckmann, Laura
Neuhann, Julia
Gathof, Birgit S
Di Cristanziano, Veronica
Hagmann, Henning
Plasma exchange with COVID-19 convalescent plasma in a patient with severe ANCA-associated vasculitis and COVID-19 pneumonia after rituximab therapy
title Plasma exchange with COVID-19 convalescent plasma in a patient with severe ANCA-associated vasculitis and COVID-19 pneumonia after rituximab therapy
title_full Plasma exchange with COVID-19 convalescent plasma in a patient with severe ANCA-associated vasculitis and COVID-19 pneumonia after rituximab therapy
title_fullStr Plasma exchange with COVID-19 convalescent plasma in a patient with severe ANCA-associated vasculitis and COVID-19 pneumonia after rituximab therapy
title_full_unstemmed Plasma exchange with COVID-19 convalescent plasma in a patient with severe ANCA-associated vasculitis and COVID-19 pneumonia after rituximab therapy
title_short Plasma exchange with COVID-19 convalescent plasma in a patient with severe ANCA-associated vasculitis and COVID-19 pneumonia after rituximab therapy
title_sort plasma exchange with covid-19 convalescent plasma in a patient with severe anca-associated vasculitis and covid-19 pneumonia after rituximab therapy
topic Exceptional Case
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244539/
https://www.ncbi.nlm.nih.gov/pubmed/35028131
http://dx.doi.org/10.1093/ckj/sfab095
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