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Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid
Sphingolipids and their synthetic enzymes have emerged as critical mediators in numerous diseases including inflammation, aging, and cancer. One enzyme in particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P), has been extensively implicated in these processes. SK catalyz...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244749/ https://www.ncbi.nlm.nih.gov/pubmed/33290840 http://dx.doi.org/10.1016/j.cellsig.2020.109875 |
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| author | Velazquez, Fabiola N. Hernandez-Corbacho, Maria Trayssac, Magali Stith, Jeffrey L. Bonica, Joseph Jean, Bernandie Pulkoski-Gross, Michael J. Carroll, Brittany L. Salama, Mohamed F. Hannun, Yusuf A. Snider, Ashley J. |
| author_facet | Velazquez, Fabiola N. Hernandez-Corbacho, Maria Trayssac, Magali Stith, Jeffrey L. Bonica, Joseph Jean, Bernandie Pulkoski-Gross, Michael J. Carroll, Brittany L. Salama, Mohamed F. Hannun, Yusuf A. Snider, Ashley J. |
| author_sort | Velazquez, Fabiola N. |
| collection | PubMed |
| description | Sphingolipids and their synthetic enzymes have emerged as critical mediators in numerous diseases including inflammation, aging, and cancer. One enzyme in particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P), has been extensively implicated in these processes. SK catalyzes the phosphorylation of sphingosine to S1P and exists as two isoforms, SK1 and SK2. In this review, we will discuss the contributions from the laboratory of Dr. Lina M. Obeid that have defined the roles for several bioactive sphingolipids in signaling and disease with an emphasis on her work defining SK1 in cellular fates and pathobiologies including proliferation, senescence, apoptosis, and inflammation. |
| format | Online Article Text |
| id | pubmed-8244749 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-82447492021-06-30 Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid Velazquez, Fabiola N. Hernandez-Corbacho, Maria Trayssac, Magali Stith, Jeffrey L. Bonica, Joseph Jean, Bernandie Pulkoski-Gross, Michael J. Carroll, Brittany L. Salama, Mohamed F. Hannun, Yusuf A. Snider, Ashley J. Cell Signal Article Sphingolipids and their synthetic enzymes have emerged as critical mediators in numerous diseases including inflammation, aging, and cancer. One enzyme in particular, sphingosine kinase (SK) and its product sphingosine-1-phosphate (S1P), has been extensively implicated in these processes. SK catalyzes the phosphorylation of sphingosine to S1P and exists as two isoforms, SK1 and SK2. In this review, we will discuss the contributions from the laboratory of Dr. Lina M. Obeid that have defined the roles for several bioactive sphingolipids in signaling and disease with an emphasis on her work defining SK1 in cellular fates and pathobiologies including proliferation, senescence, apoptosis, and inflammation. 2020-12-05 2021-03 /pmc/articles/PMC8244749/ /pubmed/33290840 http://dx.doi.org/10.1016/j.cellsig.2020.109875 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
| spellingShingle | Article Velazquez, Fabiola N. Hernandez-Corbacho, Maria Trayssac, Magali Stith, Jeffrey L. Bonica, Joseph Jean, Bernandie Pulkoski-Gross, Michael J. Carroll, Brittany L. Salama, Mohamed F. Hannun, Yusuf A. Snider, Ashley J. Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid |
| title | Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid |
| title_full | Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid |
| title_fullStr | Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid |
| title_full_unstemmed | Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid |
| title_short | Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid |
| title_sort | bioactive sphingolipids: advancements and contributions from the laboratory of dr. lina m. obeid |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244749/ https://www.ncbi.nlm.nih.gov/pubmed/33290840 http://dx.doi.org/10.1016/j.cellsig.2020.109875 |
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