Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates

We report the genome of a B.1.1.7+E484K severe acute respiratory syndrome coronavirus 2 from Southeastern Pennsylvania and compare it with all high-coverage B.1.1.7+E484K genomes (n = 235) available. Analyses showed the existence of at least 4 distinct clades of this variant circulating in the Unite...

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Detalles Bibliográficos
Autores principales: Moustafa, Ahmed M, Bianco, Colleen, Denu, Lidiya, Ahmed, Azad, Coffin, Susan E, Neide, Brandy, Everett, John, Reddy, Shantan, Rabut, Emilie, Deseignora, Jasmine, Feldman, Michael D, Rodino, Kyle G, Bushman, Frederic, Harris, Rebecca M, Chang Mell, Josh, Planet, Paul J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244812/
https://www.ncbi.nlm.nih.gov/pubmed/34254040
http://dx.doi.org/10.1093/ofid/ofab300
Descripción
Sumario:We report the genome of a B.1.1.7+E484K severe acute respiratory syndrome coronavirus 2 from Southeastern Pennsylvania and compare it with all high-coverage B.1.1.7+E484K genomes (n = 235) available. Analyses showed the existence of at least 4 distinct clades of this variant circulating in the United States and the possibility of at least 59 independent acquisitions of the E484K mutation.

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