Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates

We report the genome of a B.1.1.7+E484K severe acute respiratory syndrome coronavirus 2 from Southeastern Pennsylvania and compare it with all high-coverage B.1.1.7+E484K genomes (n = 235) available. Analyses showed the existence of at least 4 distinct clades of this variant circulating in the Unite...

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Autores principales: Moustafa, Ahmed M, Bianco, Colleen, Denu, Lidiya, Ahmed, Azad, Coffin, Susan E, Neide, Brandy, Everett, John, Reddy, Shantan, Rabut, Emilie, Deseignora, Jasmine, Feldman, Michael D, Rodino, Kyle G, Bushman, Frederic, Harris, Rebecca M, Chang Mell, Josh, Planet, Paul J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244812/
https://www.ncbi.nlm.nih.gov/pubmed/34254040
http://dx.doi.org/10.1093/ofid/ofab300
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author Moustafa, Ahmed M
Bianco, Colleen
Denu, Lidiya
Ahmed, Azad
Coffin, Susan E
Neide, Brandy
Everett, John
Reddy, Shantan
Rabut, Emilie
Deseignora, Jasmine
Feldman, Michael D
Rodino, Kyle G
Bushman, Frederic
Harris, Rebecca M
Chang Mell, Josh
Planet, Paul J
author_facet Moustafa, Ahmed M
Bianco, Colleen
Denu, Lidiya
Ahmed, Azad
Coffin, Susan E
Neide, Brandy
Everett, John
Reddy, Shantan
Rabut, Emilie
Deseignora, Jasmine
Feldman, Michael D
Rodino, Kyle G
Bushman, Frederic
Harris, Rebecca M
Chang Mell, Josh
Planet, Paul J
author_sort Moustafa, Ahmed M
collection PubMed
description We report the genome of a B.1.1.7+E484K severe acute respiratory syndrome coronavirus 2 from Southeastern Pennsylvania and compare it with all high-coverage B.1.1.7+E484K genomes (n = 235) available. Analyses showed the existence of at least 4 distinct clades of this variant circulating in the United States and the possibility of at least 59 independent acquisitions of the E484K mutation.
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spelling pubmed-82448122021-07-01 Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates Moustafa, Ahmed M Bianco, Colleen Denu, Lidiya Ahmed, Azad Coffin, Susan E Neide, Brandy Everett, John Reddy, Shantan Rabut, Emilie Deseignora, Jasmine Feldman, Michael D Rodino, Kyle G Bushman, Frederic Harris, Rebecca M Chang Mell, Josh Planet, Paul J Open Forum Infect Dis Brief Reports We report the genome of a B.1.1.7+E484K severe acute respiratory syndrome coronavirus 2 from Southeastern Pennsylvania and compare it with all high-coverage B.1.1.7+E484K genomes (n = 235) available. Analyses showed the existence of at least 4 distinct clades of this variant circulating in the United States and the possibility of at least 59 independent acquisitions of the E484K mutation. Oxford University Press 2021-06-04 /pmc/articles/PMC8244812/ /pubmed/34254040 http://dx.doi.org/10.1093/ofid/ofab300 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Moustafa, Ahmed M
Bianco, Colleen
Denu, Lidiya
Ahmed, Azad
Coffin, Susan E
Neide, Brandy
Everett, John
Reddy, Shantan
Rabut, Emilie
Deseignora, Jasmine
Feldman, Michael D
Rodino, Kyle G
Bushman, Frederic
Harris, Rebecca M
Chang Mell, Josh
Planet, Paul J
Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates
title Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates
title_full Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates
title_fullStr Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates
title_full_unstemmed Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates
title_short Comparative Analysis of Emerging B.1.1.7+E484K SARS-CoV-2 Isolates
title_sort comparative analysis of emerging b.1.1.7+e484k sars-cov-2 isolates
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244812/
https://www.ncbi.nlm.nih.gov/pubmed/34254040
http://dx.doi.org/10.1093/ofid/ofab300
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