Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution

We report a coronavirus disease 2019 case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 postdiagnosis. In addition, viral seque...

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Detalles Bibliográficos
Autores principales: Monrad, Ida, Sahlertz, Signe Risgaard, Nielsen, Stine Sofie Frank, Pedersen, Louise Ørnskov, Petersen, Mikkel Steen, Kobel, Carl Mathias, Tarpgaard, Irene Harder, Storgaard, Merete, Mortensen, Klaus Leth, Schleimann, Mariane H, Tolstrup, Martin, Vibholm, Line K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244814/
https://www.ncbi.nlm.nih.gov/pubmed/34258320
http://dx.doi.org/10.1093/ofid/ofab295
Descripción
Sumario:We report a coronavirus disease 2019 case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 postdiagnosis. In addition, viral sequencing indicates major changes in the spike protein over time, temporally associated with convalescent plasma treatment.

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