Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution

We report a coronavirus disease 2019 case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 postdiagnosis. In addition, viral seque...

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Autores principales: Monrad, Ida, Sahlertz, Signe Risgaard, Nielsen, Stine Sofie Frank, Pedersen, Louise Ørnskov, Petersen, Mikkel Steen, Kobel, Carl Mathias, Tarpgaard, Irene Harder, Storgaard, Merete, Mortensen, Klaus Leth, Schleimann, Mariane H, Tolstrup, Martin, Vibholm, Line K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244814/
https://www.ncbi.nlm.nih.gov/pubmed/34258320
http://dx.doi.org/10.1093/ofid/ofab295
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author Monrad, Ida
Sahlertz, Signe Risgaard
Nielsen, Stine Sofie Frank
Pedersen, Louise Ørnskov
Petersen, Mikkel Steen
Kobel, Carl Mathias
Tarpgaard, Irene Harder
Storgaard, Merete
Mortensen, Klaus Leth
Schleimann, Mariane H
Tolstrup, Martin
Vibholm, Line K
author_facet Monrad, Ida
Sahlertz, Signe Risgaard
Nielsen, Stine Sofie Frank
Pedersen, Louise Ørnskov
Petersen, Mikkel Steen
Kobel, Carl Mathias
Tarpgaard, Irene Harder
Storgaard, Merete
Mortensen, Klaus Leth
Schleimann, Mariane H
Tolstrup, Martin
Vibholm, Line K
author_sort Monrad, Ida
collection PubMed
description We report a coronavirus disease 2019 case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 postdiagnosis. In addition, viral sequencing indicates major changes in the spike protein over time, temporally associated with convalescent plasma treatment.
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spelling pubmed-82448142021-07-01 Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution Monrad, Ida Sahlertz, Signe Risgaard Nielsen, Stine Sofie Frank Pedersen, Louise Ørnskov Petersen, Mikkel Steen Kobel, Carl Mathias Tarpgaard, Irene Harder Storgaard, Merete Mortensen, Klaus Leth Schleimann, Mariane H Tolstrup, Martin Vibholm, Line K Open Forum Infect Dis Brief Report We report a coronavirus disease 2019 case with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persisting beyond 333 days in an immunocompromised patient with chronic lymphocytic leukemia, asymptomatically carrying infectious SARS-CoV-2 at day 197 postdiagnosis. In addition, viral sequencing indicates major changes in the spike protein over time, temporally associated with convalescent plasma treatment. Oxford University Press 2021-06-04 /pmc/articles/PMC8244814/ /pubmed/34258320 http://dx.doi.org/10.1093/ofid/ofab295 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Monrad, Ida
Sahlertz, Signe Risgaard
Nielsen, Stine Sofie Frank
Pedersen, Louise Ørnskov
Petersen, Mikkel Steen
Kobel, Carl Mathias
Tarpgaard, Irene Harder
Storgaard, Merete
Mortensen, Klaus Leth
Schleimann, Mariane H
Tolstrup, Martin
Vibholm, Line K
Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution
title Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution
title_full Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution
title_fullStr Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution
title_full_unstemmed Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution
title_short Persistent Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Immunocompromised Host Displaying Treatment Induced Viral Evolution
title_sort persistent severe acute respiratory syndrome coronavirus 2 infection in immunocompromised host displaying treatment induced viral evolution
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244814/
https://www.ncbi.nlm.nih.gov/pubmed/34258320
http://dx.doi.org/10.1093/ofid/ofab295
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