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HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study

Anti-thyroid peroxidase antibody (TPO-Ab) is revealed to be inversely associated with thyroid cysts among euthyroid population. TPO-Ab causes autoimmune thyroiditis by bolstering thyroid inflammation. Therefore, at least partly, absence of thyroid cysts could indicate latent thyroid damage. Since pa...

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Autores principales: Shimizu, Yuji, Kawashiri, Shin-Ya, Noguchi, Yuko, Nagata, Yasuhiro, Maeda, Takahiro, Hayashida, Naomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244890/
https://www.ncbi.nlm.nih.gov/pubmed/34191857
http://dx.doi.org/10.1371/journal.pone.0253841
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author Shimizu, Yuji
Kawashiri, Shin-Ya
Noguchi, Yuko
Nagata, Yasuhiro
Maeda, Takahiro
Hayashida, Naomi
author_facet Shimizu, Yuji
Kawashiri, Shin-Ya
Noguchi, Yuko
Nagata, Yasuhiro
Maeda, Takahiro
Hayashida, Naomi
author_sort Shimizu, Yuji
collection PubMed
description Anti-thyroid peroxidase antibody (TPO-Ab) is revealed to be inversely associated with thyroid cysts among euthyroid population. TPO-Ab causes autoimmune thyroiditis by bolstering thyroid inflammation. Therefore, at least partly, absence of thyroid cysts could indicate latent thyroid damage. Since participants with subclinical hypothyroidism are reported to have higher HbA1c than normal healthy controls, HbA1c could be inversely associated with thyroid cysts through a mechanism reflecting latent thyroid damage. To investigate the association between HbA1c and thyroid cysts among a euthyroid population, a cross-sectional study was conducted on 1,724 Japanese individuals who were within the normal range of thyroid function [i.e., normal range of free triiodothyronine (T3) and free thyroxine (T4)] and aged 40–74 years. Among this study population, 564 were diagnosed with thyroid cysts. Independently of thyroid related hormones [thyroid stimulating hormone (TSH), free T3, and free T4] and known cardiovascular risk factors, HbA1c was found to be significantly inversely associated with the presence of thyroid cysts. This association remained significant even after this analysis was limited to participants within a normal range of TSH. The fully adjusted odds ratios (ORs) of thyroid cysts for 1 standard deviation (SD) increment of HbA1c were 0.84 (0.74, 0.95) for total participants and 0.80 (0.70, 0.92) for participants within a normal range of TSH. Among participants with normal thyroid function, HbA1c was inversely associated with the presence of thyroid cysts. The absence of thyroid cysts and higher levels of HbA1c could indicate the latent functional damage of the thyroid.
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spelling pubmed-82448902021-07-12 HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study Shimizu, Yuji Kawashiri, Shin-Ya Noguchi, Yuko Nagata, Yasuhiro Maeda, Takahiro Hayashida, Naomi PLoS One Research Article Anti-thyroid peroxidase antibody (TPO-Ab) is revealed to be inversely associated with thyroid cysts among euthyroid population. TPO-Ab causes autoimmune thyroiditis by bolstering thyroid inflammation. Therefore, at least partly, absence of thyroid cysts could indicate latent thyroid damage. Since participants with subclinical hypothyroidism are reported to have higher HbA1c than normal healthy controls, HbA1c could be inversely associated with thyroid cysts through a mechanism reflecting latent thyroid damage. To investigate the association between HbA1c and thyroid cysts among a euthyroid population, a cross-sectional study was conducted on 1,724 Japanese individuals who were within the normal range of thyroid function [i.e., normal range of free triiodothyronine (T3) and free thyroxine (T4)] and aged 40–74 years. Among this study population, 564 were diagnosed with thyroid cysts. Independently of thyroid related hormones [thyroid stimulating hormone (TSH), free T3, and free T4] and known cardiovascular risk factors, HbA1c was found to be significantly inversely associated with the presence of thyroid cysts. This association remained significant even after this analysis was limited to participants within a normal range of TSH. The fully adjusted odds ratios (ORs) of thyroid cysts for 1 standard deviation (SD) increment of HbA1c were 0.84 (0.74, 0.95) for total participants and 0.80 (0.70, 0.92) for participants within a normal range of TSH. Among participants with normal thyroid function, HbA1c was inversely associated with the presence of thyroid cysts. The absence of thyroid cysts and higher levels of HbA1c could indicate the latent functional damage of the thyroid. Public Library of Science 2021-06-30 /pmc/articles/PMC8244890/ /pubmed/34191857 http://dx.doi.org/10.1371/journal.pone.0253841 Text en © 2021 Shimizu et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Shimizu, Yuji
Kawashiri, Shin-Ya
Noguchi, Yuko
Nagata, Yasuhiro
Maeda, Takahiro
Hayashida, Naomi
HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study
title HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study
title_full HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study
title_fullStr HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study
title_full_unstemmed HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study
title_short HbA1c is inversely associated with thyroid cysts in a euthyroid population: A cross-sectional study
title_sort hba1c is inversely associated with thyroid cysts in a euthyroid population: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8244890/
https://www.ncbi.nlm.nih.gov/pubmed/34191857
http://dx.doi.org/10.1371/journal.pone.0253841
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