Letrozole for Female Infertility

Letrozole, an aromatase inhibitor that blocks estrogen synthesis by inhibiting the final step of the estrogen biosynthetic pathway, has been used in the applications of a wide range of infertility settings. It has been more than 20 years since the initial clinical trial of letrozole for ovulation in...

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Detalles Bibliográficos
Autores principales: Yang, Ai-Min, Cui, Na, Sun, Yi-Fei, Hao, Gui-Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245002/
https://www.ncbi.nlm.nih.gov/pubmed/34220713
http://dx.doi.org/10.3389/fendo.2021.676133
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author Yang, Ai-Min
Cui, Na
Sun, Yi-Fei
Hao, Gui-Min
author_facet Yang, Ai-Min
Cui, Na
Sun, Yi-Fei
Hao, Gui-Min
author_sort Yang, Ai-Min
collection PubMed
description Letrozole, an aromatase inhibitor that blocks estrogen synthesis by inhibiting the final step of the estrogen biosynthetic pathway, has been used in the applications of a wide range of infertility settings. It has been more than 20 years since the initial clinical trial of letrozole for ovulation induction. In light of the accumulating clinical and basic evidence, the efficacy and safety of letrozole have been identified. This mini review focuses on our current knowledge of the applications and mechanisms of letrozole for female infertility and various questions are put forward about how letrozole could be more effectively used.
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spelling pubmed-82450022021-07-01 Letrozole for Female Infertility Yang, Ai-Min Cui, Na Sun, Yi-Fei Hao, Gui-Min Front Endocrinol (Lausanne) Endocrinology Letrozole, an aromatase inhibitor that blocks estrogen synthesis by inhibiting the final step of the estrogen biosynthetic pathway, has been used in the applications of a wide range of infertility settings. It has been more than 20 years since the initial clinical trial of letrozole for ovulation induction. In light of the accumulating clinical and basic evidence, the efficacy and safety of letrozole have been identified. This mini review focuses on our current knowledge of the applications and mechanisms of letrozole for female infertility and various questions are put forward about how letrozole could be more effectively used. Frontiers Media S.A. 2021-06-16 /pmc/articles/PMC8245002/ /pubmed/34220713 http://dx.doi.org/10.3389/fendo.2021.676133 Text en Copyright © 2021 Yang, Cui, Sun and Hao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Yang, Ai-Min
Cui, Na
Sun, Yi-Fei
Hao, Gui-Min
Letrozole for Female Infertility
title Letrozole for Female Infertility
title_full Letrozole for Female Infertility
title_fullStr Letrozole for Female Infertility
title_full_unstemmed Letrozole for Female Infertility
title_short Letrozole for Female Infertility
title_sort letrozole for female infertility
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245002/
https://www.ncbi.nlm.nih.gov/pubmed/34220713
http://dx.doi.org/10.3389/fendo.2021.676133
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AT cuina letrozoleforfemaleinfertility
AT sunyifei letrozoleforfemaleinfertility
AT haoguimin letrozoleforfemaleinfertility

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