The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report)

Background  Neonatal hemochromatosis (NH) is a rare condition that was the main reason for liver transplantation in infants. With the realization that NH results from the fetal complement-mediated liver injury, intravenous immunoglobulins (IVIG) were successfully introduced for the treatment. Case P...

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Autores principales: Mugarab-Samedi, Veronica, Ryan, Michelle D., Awad, Essa Hamdan Al, Elsharkawy, Adel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical Publishers, Inc. 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245207/
https://www.ncbi.nlm.nih.gov/pubmed/34221693
http://dx.doi.org/10.1055/s-0041-1731311
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author Mugarab-Samedi, Veronica
Ryan, Michelle D.
Awad, Essa Hamdan Al
Elsharkawy, Adel
author_facet Mugarab-Samedi, Veronica
Ryan, Michelle D.
Awad, Essa Hamdan Al
Elsharkawy, Adel
author_sort Mugarab-Samedi, Veronica
collection PubMed
description Background  Neonatal hemochromatosis (NH) is a rare condition that was the main reason for liver transplantation in infants. With the realization that NH results from the fetal complement-mediated liver injury, intravenous immunoglobulins (IVIG) were successfully introduced for the treatment. Case Presentation  We present two cases of NH from the same family to illustrate the role of antenatal treatment with IVIG in alleviation and possible prevention of this serious morbidity. Conclusion  A prenatal treatment and early postnatal administration of IVIG are effective ways to manage NH that help to reduce the severity of the symptoms, prevent liver failure, and avoid the need for liver transplantation.
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spelling pubmed-82452072021-07-02 The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report) Mugarab-Samedi, Veronica Ryan, Michelle D. Awad, Essa Hamdan Al Elsharkawy, Adel AJP Rep Background  Neonatal hemochromatosis (NH) is a rare condition that was the main reason for liver transplantation in infants. With the realization that NH results from the fetal complement-mediated liver injury, intravenous immunoglobulins (IVIG) were successfully introduced for the treatment. Case Presentation  We present two cases of NH from the same family to illustrate the role of antenatal treatment with IVIG in alleviation and possible prevention of this serious morbidity. Conclusion  A prenatal treatment and early postnatal administration of IVIG are effective ways to manage NH that help to reduce the severity of the symptoms, prevent liver failure, and avoid the need for liver transplantation. Thieme Medical Publishers, Inc. 2021-04 2021-06-30 /pmc/articles/PMC8245207/ /pubmed/34221693 http://dx.doi.org/10.1055/s-0041-1731311 Text en The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Mugarab-Samedi, Veronica
Ryan, Michelle D.
Awad, Essa Hamdan Al
Elsharkawy, Adel
The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report)
title The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report)
title_full The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report)
title_fullStr The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report)
title_full_unstemmed The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report)
title_short The Effect of Prenatal and Postnatal Treatment with Intravenous Immunoglobulin on Severity of Neonatal Hemochromatosis: The Tale of Two Brothers (Case Report)
title_sort effect of prenatal and postnatal treatment with intravenous immunoglobulin on severity of neonatal hemochromatosis: the tale of two brothers (case report)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245207/
https://www.ncbi.nlm.nih.gov/pubmed/34221693
http://dx.doi.org/10.1055/s-0041-1731311
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