Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity

Memory CD8 T cells can provide long-term protection against tumors, which depends on their enhanced proliferative capacity, self-renewal and unique metabolic rewiring to sustain cellular fitness. Specifically, memory CD8 T cells engage oxidative phosphorylation and fatty acid oxidation to fulfill th...

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Detalles Bibliográficos
Autores principales: Dumauthioz, Nina, Tschumi, Benjamin, Wenes, Mathias, Marti, Bastien, Wang, Haiping, Franco, Fabien, Li, Wenhui, Lopez-Mejia, Isabel C., Fajas, Lluis, Ho, Ping-Chih, Donda, Alena, Romero, Pedro, Zhang, Lianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245409/
https://www.ncbi.nlm.nih.gov/pubmed/32055005
http://dx.doi.org/10.1038/s41423-020-0365-3

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