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Role of amyloid β-peptide in the pathogenesis of age-related macular degeneration

Age-related macular degeneration (AMD) is the most common eye disease in elderly patients, which could lead to irreversible vision loss and blindness. Increasing evidence indicates that amyloid β-peptide (Aβ) might be associated with the pathogenesis of AMD. In this review, we would like to summaris...

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Autores principales: Wang, Minwei, Su, Shiqi, Jiang, Shaoyun, Sun, Xinghuai, Wang, Jiantao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245440/
https://www.ncbi.nlm.nih.gov/pubmed/34263061
http://dx.doi.org/10.1136/bmjophth-2021-000774
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author Wang, Minwei
Su, Shiqi
Jiang, Shaoyun
Sun, Xinghuai
Wang, Jiantao
author_facet Wang, Minwei
Su, Shiqi
Jiang, Shaoyun
Sun, Xinghuai
Wang, Jiantao
author_sort Wang, Minwei
collection PubMed
description Age-related macular degeneration (AMD) is the most common eye disease in elderly patients, which could lead to irreversible vision loss and blindness. Increasing evidence indicates that amyloid β-peptide (Aβ) might be associated with the pathogenesis of AMD. In this review, we would like to summarise the current findings in this field. The literature search was done from 1995 to Feb, 2021 with following keywords, ‘Amyloid β-peptide and age-related macular degeneration’, ‘Inflammation and age-related macular degeneration’, ‘Angiogenesis and age-related macular degeneration’, ‘Actin cytoskeleton and amyloid β-peptide’, ‘Mitochondrial dysfunction and amyloid β-peptide’, ‘Ribosomal dysregulation and amyloid β-peptide’ using search engines Pubmed, Google Scholar and Web of Science. Aβ congregates in subretinal drusen of patients with AMD and participates in the pathogenesis of AMD through enhancing inflammatory activity, inducing mitochondrial dysfunction, altering ribosomal function, regulating the lysosomal pathway, affecting RNA splicing, modulating angiogenesis and modifying cell structure in AMD. The methods targeting Aβ are shown to inhibit inflammatory signalling pathway and restore the function of retinal pigment epithelium cells and photoreceptor cells in the subretinal region. Targeting Aβ may provide a novel therapeutic strategy for AMD.
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spelling pubmed-82454402021-07-13 Role of amyloid β-peptide in the pathogenesis of age-related macular degeneration Wang, Minwei Su, Shiqi Jiang, Shaoyun Sun, Xinghuai Wang, Jiantao BMJ Open Ophthalmol Review Age-related macular degeneration (AMD) is the most common eye disease in elderly patients, which could lead to irreversible vision loss and blindness. Increasing evidence indicates that amyloid β-peptide (Aβ) might be associated with the pathogenesis of AMD. In this review, we would like to summarise the current findings in this field. The literature search was done from 1995 to Feb, 2021 with following keywords, ‘Amyloid β-peptide and age-related macular degeneration’, ‘Inflammation and age-related macular degeneration’, ‘Angiogenesis and age-related macular degeneration’, ‘Actin cytoskeleton and amyloid β-peptide’, ‘Mitochondrial dysfunction and amyloid β-peptide’, ‘Ribosomal dysregulation and amyloid β-peptide’ using search engines Pubmed, Google Scholar and Web of Science. Aβ congregates in subretinal drusen of patients with AMD and participates in the pathogenesis of AMD through enhancing inflammatory activity, inducing mitochondrial dysfunction, altering ribosomal function, regulating the lysosomal pathway, affecting RNA splicing, modulating angiogenesis and modifying cell structure in AMD. The methods targeting Aβ are shown to inhibit inflammatory signalling pathway and restore the function of retinal pigment epithelium cells and photoreceptor cells in the subretinal region. Targeting Aβ may provide a novel therapeutic strategy for AMD. BMJ Publishing Group 2021-06-29 /pmc/articles/PMC8245440/ /pubmed/34263061 http://dx.doi.org/10.1136/bmjophth-2021-000774 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Review
Wang, Minwei
Su, Shiqi
Jiang, Shaoyun
Sun, Xinghuai
Wang, Jiantao
Role of amyloid β-peptide in the pathogenesis of age-related macular degeneration
title Role of amyloid β-peptide in the pathogenesis of age-related macular degeneration
title_full Role of amyloid β-peptide in the pathogenesis of age-related macular degeneration
title_fullStr Role of amyloid β-peptide in the pathogenesis of age-related macular degeneration
title_full_unstemmed Role of amyloid β-peptide in the pathogenesis of age-related macular degeneration
title_short Role of amyloid β-peptide in the pathogenesis of age-related macular degeneration
title_sort role of amyloid β-peptide in the pathogenesis of age-related macular degeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245440/
https://www.ncbi.nlm.nih.gov/pubmed/34263061
http://dx.doi.org/10.1136/bmjophth-2021-000774
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