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Cancer Aging Research Group (CARG) score in older adults undergoing curative intent chemotherapy: a prospective cohort study

IMPORTANCE: The Cancer Aging Research Group (CARG) toxicity score is used to assess toxicity risk in geriatric patients receiving chemotherapy. OBJECTIVE: The primary aim was to validate the CARG score in geriatric patients treated with curative intent chemotherapy in predicting grade 3–5 toxicities...

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Autores principales: Ostwal, Vikas, Ramaswamy, Anant, Bhargava, Prabhat, Hatkhambkar, Tejaswee, Swami, Rohit, Rastogi, Sameer, Mandavkar, Sarika, Ghosh, Jaya, Bajpai, Jyoti, Gulia, Seema, Srinivas, Sujay, Rath, Sushmita, Gupta, Sudeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245449/
https://www.ncbi.nlm.nih.gov/pubmed/34187825
http://dx.doi.org/10.1136/bmjopen-2020-047376
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author Ostwal, Vikas
Ramaswamy, Anant
Bhargava, Prabhat
Hatkhambkar, Tejaswee
Swami, Rohit
Rastogi, Sameer
Mandavkar, Sarika
Ghosh, Jaya
Bajpai, Jyoti
Gulia, Seema
Srinivas, Sujay
Rath, Sushmita
Gupta, Sudeep
author_facet Ostwal, Vikas
Ramaswamy, Anant
Bhargava, Prabhat
Hatkhambkar, Tejaswee
Swami, Rohit
Rastogi, Sameer
Mandavkar, Sarika
Ghosh, Jaya
Bajpai, Jyoti
Gulia, Seema
Srinivas, Sujay
Rath, Sushmita
Gupta, Sudeep
author_sort Ostwal, Vikas
collection PubMed
description IMPORTANCE: The Cancer Aging Research Group (CARG) toxicity score is used to assess toxicity risk in geriatric patients receiving chemotherapy. OBJECTIVE: The primary aim was to validate the CARG score in geriatric patients treated with curative intent chemotherapy in predicting grade 3–5 toxicities. DESIGN: This was a longitudinal prospective observational study. SETTING: Tata Memorial Hospital, Mumbai, India, a tertiary cancer care referral centre. PARTICIPANTS: Patients, aged ≥65 years, with gastrointestinal, breast or gynaecological stage I–III cancers being planned for curative intent chemotherapy. A total of 270 patients were required for accrual in the study. EXPOSURE(S): Total risk score ranged from 0 (lowest toxicity risk) to 19 (highest toxicity risk). MAIN OUTCOME(S) AND MEASURE(S): The primary endpoint of the study was to evaluate whether the CARG risk score predicted for grade 3–5 toxicities. RESULTS: The study cohort of 270 patients had a mean age of 69 (65–83) years, with the most common cancers being gastrointestinal (79%). Fifty-two per cent of patients had atleast one grade 3–5 toxicity. The risk of toxicity was increased with an increasing risk score (42% low risk, 51% medium risk and 79% high risk; p<0.001). There was no association between either Eastern Cooperative Oncology Group (ECOG) performance status (p=0.69) or age-adjusted Charlson Comorbidity Index (p=0.79) risk categories and grade 3–5 chemotherapy toxicities. CONCLUSIONS AND RELEVANCE: This study validates the CARG risk score in predicting for grade 3–5 toxicities in geriatric oncology patients receiving curative intent chemotherapy and can be considered as the standard of care before planning chemotherapy in every elderly patient. TRIAL REGISTRATION NUMBER: CTRI/2016/10/007357; Results.
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spelling pubmed-82454492021-07-13 Cancer Aging Research Group (CARG) score in older adults undergoing curative intent chemotherapy: a prospective cohort study Ostwal, Vikas Ramaswamy, Anant Bhargava, Prabhat Hatkhambkar, Tejaswee Swami, Rohit Rastogi, Sameer Mandavkar, Sarika Ghosh, Jaya Bajpai, Jyoti Gulia, Seema Srinivas, Sujay Rath, Sushmita Gupta, Sudeep BMJ Open Geriatric Medicine IMPORTANCE: The Cancer Aging Research Group (CARG) toxicity score is used to assess toxicity risk in geriatric patients receiving chemotherapy. OBJECTIVE: The primary aim was to validate the CARG score in geriatric patients treated with curative intent chemotherapy in predicting grade 3–5 toxicities. DESIGN: This was a longitudinal prospective observational study. SETTING: Tata Memorial Hospital, Mumbai, India, a tertiary cancer care referral centre. PARTICIPANTS: Patients, aged ≥65 years, with gastrointestinal, breast or gynaecological stage I–III cancers being planned for curative intent chemotherapy. A total of 270 patients were required for accrual in the study. EXPOSURE(S): Total risk score ranged from 0 (lowest toxicity risk) to 19 (highest toxicity risk). MAIN OUTCOME(S) AND MEASURE(S): The primary endpoint of the study was to evaluate whether the CARG risk score predicted for grade 3–5 toxicities. RESULTS: The study cohort of 270 patients had a mean age of 69 (65–83) years, with the most common cancers being gastrointestinal (79%). Fifty-two per cent of patients had atleast one grade 3–5 toxicity. The risk of toxicity was increased with an increasing risk score (42% low risk, 51% medium risk and 79% high risk; p<0.001). There was no association between either Eastern Cooperative Oncology Group (ECOG) performance status (p=0.69) or age-adjusted Charlson Comorbidity Index (p=0.79) risk categories and grade 3–5 chemotherapy toxicities. CONCLUSIONS AND RELEVANCE: This study validates the CARG risk score in predicting for grade 3–5 toxicities in geriatric oncology patients receiving curative intent chemotherapy and can be considered as the standard of care before planning chemotherapy in every elderly patient. TRIAL REGISTRATION NUMBER: CTRI/2016/10/007357; Results. BMJ Publishing Group 2021-06-29 /pmc/articles/PMC8245449/ /pubmed/34187825 http://dx.doi.org/10.1136/bmjopen-2020-047376 Text en © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Geriatric Medicine
Ostwal, Vikas
Ramaswamy, Anant
Bhargava, Prabhat
Hatkhambkar, Tejaswee
Swami, Rohit
Rastogi, Sameer
Mandavkar, Sarika
Ghosh, Jaya
Bajpai, Jyoti
Gulia, Seema
Srinivas, Sujay
Rath, Sushmita
Gupta, Sudeep
Cancer Aging Research Group (CARG) score in older adults undergoing curative intent chemotherapy: a prospective cohort study
title Cancer Aging Research Group (CARG) score in older adults undergoing curative intent chemotherapy: a prospective cohort study
title_full Cancer Aging Research Group (CARG) score in older adults undergoing curative intent chemotherapy: a prospective cohort study
title_fullStr Cancer Aging Research Group (CARG) score in older adults undergoing curative intent chemotherapy: a prospective cohort study
title_full_unstemmed Cancer Aging Research Group (CARG) score in older adults undergoing curative intent chemotherapy: a prospective cohort study
title_short Cancer Aging Research Group (CARG) score in older adults undergoing curative intent chemotherapy: a prospective cohort study
title_sort cancer aging research group (carg) score in older adults undergoing curative intent chemotherapy: a prospective cohort study
topic Geriatric Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245449/
https://www.ncbi.nlm.nih.gov/pubmed/34187825
http://dx.doi.org/10.1136/bmjopen-2020-047376
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