All-metal terahertz metamaterial biosensor for protein detection

In this paper, a terahertz (THz) biosensor based on all-metal metamaterial is theoretically investigated and experimentally verified. This THz metamaterial biosensor uses stainless steel materials that are manufactured via laser-drilling technology. The simulation results show that the maximum refra...

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Autores principales: Wang, Gangqi, Zhu, Fengjie, Lang, Tingting, Liu, Jianjun, Hong, Zhi, Qin, Jianyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245611/
https://www.ncbi.nlm.nih.gov/pubmed/34191133
http://dx.doi.org/10.1186/s11671-021-03566-3
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author Wang, Gangqi
Zhu, Fengjie
Lang, Tingting
Liu, Jianjun
Hong, Zhi
Qin, Jianyuan
author_facet Wang, Gangqi
Zhu, Fengjie
Lang, Tingting
Liu, Jianjun
Hong, Zhi
Qin, Jianyuan
author_sort Wang, Gangqi
collection PubMed
description In this paper, a terahertz (THz) biosensor based on all-metal metamaterial is theoretically investigated and experimentally verified. This THz metamaterial biosensor uses stainless steel materials that are manufactured via laser-drilling technology. The simulation results show that the maximum refractive index sensitivity and the figure of merit of this metamaterial sensor are 294.95 GHz/RIU and 4.03, respectively. Then, bovine serum albumin was chosen as the detection substance to assess this biosensor’s effectiveness. The experiment results show that the detection sensitivity is 72.81 GHz/(ng/mm(2)) and the limit of detection is 0.035 mg/mL. This THz metamaterial biosensor is simple, cost-effective, easy to fabricate, and has great potential in various biosensing applications.
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spelling pubmed-82456112021-07-20 All-metal terahertz metamaterial biosensor for protein detection Wang, Gangqi Zhu, Fengjie Lang, Tingting Liu, Jianjun Hong, Zhi Qin, Jianyuan Nanoscale Res Lett Nano Express In this paper, a terahertz (THz) biosensor based on all-metal metamaterial is theoretically investigated and experimentally verified. This THz metamaterial biosensor uses stainless steel materials that are manufactured via laser-drilling technology. The simulation results show that the maximum refractive index sensitivity and the figure of merit of this metamaterial sensor are 294.95 GHz/RIU and 4.03, respectively. Then, bovine serum albumin was chosen as the detection substance to assess this biosensor’s effectiveness. The experiment results show that the detection sensitivity is 72.81 GHz/(ng/mm(2)) and the limit of detection is 0.035 mg/mL. This THz metamaterial biosensor is simple, cost-effective, easy to fabricate, and has great potential in various biosensing applications. Springer US 2021-06-30 /pmc/articles/PMC8245611/ /pubmed/34191133 http://dx.doi.org/10.1186/s11671-021-03566-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Nano Express
Wang, Gangqi
Zhu, Fengjie
Lang, Tingting
Liu, Jianjun
Hong, Zhi
Qin, Jianyuan
All-metal terahertz metamaterial biosensor for protein detection
title All-metal terahertz metamaterial biosensor for protein detection
title_full All-metal terahertz metamaterial biosensor for protein detection
title_fullStr All-metal terahertz metamaterial biosensor for protein detection
title_full_unstemmed All-metal terahertz metamaterial biosensor for protein detection
title_short All-metal terahertz metamaterial biosensor for protein detection
title_sort all-metal terahertz metamaterial biosensor for protein detection
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245611/
https://www.ncbi.nlm.nih.gov/pubmed/34191133
http://dx.doi.org/10.1186/s11671-021-03566-3
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