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Extensive expansion of the chemical diversity of fusidane-type antibiotics using a stochastic combinational strategy

Fusidane-type antibiotics, represented by helvolic acid, fusidic acid and cephalosporin P(1), are fungi-derived antimicrobials with little cross-resistance to commonly used antibiotics. Generation of new fusidane-type derivatives is therefore of great value, but this is hindered by available approac...

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Detalles Bibliográficos
Autores principales: Song, Xiaojun, Lv, Jianming, Cao, Zhiqin, Huang, Huiyun, Chen, Guodong, Awakawa, Takayoshi, Hu, Dan, Gao, Hao, Abe, Ikuro, Yao, Xinsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245791/
https://www.ncbi.nlm.nih.gov/pubmed/34221876
http://dx.doi.org/10.1016/j.apsb.2020.12.007