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Development of a highly-specific (18)F-labeled irreversible positron emission tomography tracer for monoacylglycerol lipase mapping

As a serine hydrolase, monoacylglycerol lipase (MAGL) is principally responsible for the metabolism of 2-arachidonoylglycerol (2-AG) in the central nervous system (CNS), leading to the formation of arachidonic acid (AA). Dysfunction of MAGL has been associated with multiple CNS disorders and symptom...

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Detalles Bibliográficos
Autores principales:	Chen, Zhen, Mori, Wakana, Rong, Jian, Schafroth, Michael A., Shao, Tuo, Van, Richard S., Ogasawara, Daisuke, Yamasaki, Tomoteru, Hiraishi, Atsuto, Hatori, Akiko, Chen, Jiahui, Zhang, Yiding, Hu, Kuan, Fujinaga, Masayuki, Sun, Jiyun, Yu, Qingzhen, Collier, Thomas L., Shao, Yihan, Cravatt, Benjamin F., Josephson, Lee, Zhang, Ming-Rong, Liang, Steven H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245801/ https://www.ncbi.nlm.nih.gov/pubmed/34221877 http://dx.doi.org/10.1016/j.apsb.2021.01.021

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